Manganese dioxide/glucose oxidase @ hyaluronic acid composite anticancer material, and preparation and application of composite anticancer material

A technology of glucose oxidase and manganese dioxide, which is applied in the field of nanotechnology and cancer treatment, can solve the problems of insufficient selectivity and low anticancer activity, and achieve the effect of good selectivity, low toxicity and side effects, and efficient and precise cancer treatment
CN110755407AActive Publication Date: 2020-02-07CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGY
Publication Date
2020-02-07

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Abstract

The invention belongs to the technical field of anticancer drugs, and particularly discloses a manganese dioxide / glucose oxidase @ hyaluronic acid composite anticancer material. The composite anticancer material comprises a core and a shell covering the core, wherein the core comprises a manganese dioxide nanosheet and glucose oxidase modified on the surface of the manganese dioxide nanosheet; andthe shell is hyaluronic acid. The invention further provides preparation and an application of the anticancer material. Studies find that the composite material can effectively and synergistically improve selectivity of cancer cells and normal cells, efficiently and specifically kill the cancer cells, and induce apoptosis of many cancer cells at a low dose through synergy of innovative componentsand composite morphology of the components; and in addition, the material does not influence metabolism of the normal cells basically and has small toxic and side effects.
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Description

Technical field

[0001] The invention belongs to the field of nanotechnology and cancer treatment, and relates to nano composite drugs based on manganese dioxide nanosheets, glucose oxidase, and hyaluronic acid. Background technique

[0002] According to statistics from the World Health Organization in 2015, global cancer deaths reached 8.8 million, and cancer has become the second leading cause of death in the world. To this day, cancer remains a major challenge to public health. Conventional molecular therapies and chemotherapy based on tight ligand-receptor interactions or nucleic acid modification have the limitations of poor stability, poor specificity, and serious side effects. To a large extent, they cannot meet the physical barriers of cancer cells and tumor heterogeneity. The challenges posed by complexity, drug resistance and metastasis. Since the early 1950s, researchers in related fields have successively developed many effective cancer treatment methods, such as che...

Claims

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