Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol
Patent Information
- Authority / Receiving Office
- US · United States
- Patent Type
- Applications(United States)
- Current Assignee / Owner
- MEMORIAL SLOAN KETTERING CANCER CENT
- Publication Date
- 2003-05-29
- Estimated Expiration
- Not applicable · inactive patent
Abstract
Description
1. FIELD OF INVENTION
[0001] The present invention relates to methods and compositions for the treatment of leukemia, lymphoma, and certain other cancers.
[0002] More specifically, the present invention relates to the novel uses of arsenic trioxide and an organic arsenic compound for treating acute leukemia and chronic leukemia.2. BACKGROUND OF THE INVENTION2.1. Cancer
[0003] Cancer is characterized primarily by an increase in the number of abnormal cells derived from a given normal tissue, invasion of adjacent tissues by these abnormal cells, and lymphatic or blood-borne spread of malignant cells to regional lymph nodes and to distant sites (metastasis). Clinical data and molecular biologic studies indicate that cancer is a multistep process that begins with minor preneoplastic changes, which may under certain conditions progress to neoplasia.
[0004] Pre-malignant abnormal cell growth as exemplified by hyperplasia, metaplasia, and dysplasia (for review of such abnormal growth condition...