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Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol

a technology of arsenic trioxide and arsenic trioxide, which is applied in the field of producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol, can solve the problems of well-known toxicity of arsenic trioxide, and achieve the effect of improving the quality of life of patients

Inactive Publication Date: 2003-05-29
MEMORIAL SLOAN KETTERING CANCER CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, while the active chemical ingredient(s) of Fowler's solution was not determined, its toxicity was well recognized.

Method used

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Embodiment Construction

[0019] Methods and compositions for the treatment of leukemia, lymphoma or solid tumors are described herein. This invention provides a method of treating acute or chronic leukemia, lymphoma, or solid tumors in a human which comprises administering to a human in need of such therapy a therapeutically effective and non-lethal amount of one or more arsenic compounds, such as arsenic trioxide or melarsoprol.

[0020] The invention also includes a method of treating leukemia in a human who has become refractory to other forms of treatment which comprises administering to a human arsenic trioxide or melarsoprol in combination with another chemotherapeutic agent, e.g., all-trans retinoic acid (ATRA).

[0021] The invention also relates to a method for the manufacture of pharmaceutical compositions comprising arsenic trioxide. It is preferred that pharmaceutical compositions of the present invention exhibit reduced toxicity, improved efficacy, improved stability during storage and use, and that ...

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PUM

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Abstract

The invention relates to the use of arsenic compounds to treat a variety of leukemia, lymphoma and solid tumors. Further, the arsenic compounds may be used in combination with other therapeutic agents, such as a retinoid. The invention also provides a process for producing arsenic trioxide formulations.

Description

1. FIELD OF INVENTION[0001] The present invention relates to methods and compositions for the treatment of leukemia, lymphoma, and certain other cancers.[0002] More specifically, the present invention relates to the novel uses of arsenic trioxide and an organic arsenic compound for treating acute leukemia and chronic leukemia.2. BACKGROUND OF THE INVENTION2.1. Cancer[0003] Cancer is characterized primarily by an increase in the number of abnormal cells derived from a given normal tissue, invasion of adjacent tissues by these abnormal cells, and lymphatic or blood-borne spread of malignant cells to regional lymph nodes and to distant sites (metastasis). Clinical data and molecular biologic studies indicate that cancer is a multistep process that begins with minor preneoplastic changes, which may under certain conditions progress to neoplasia.[0004] Pre-malignant abnormal cell growth as exemplified by hyperplasia, metaplasia, and dysplasia (for review of such abnormal growth condition...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/203A61K31/285A61K31/53A61K31/555A61K33/24A61K33/36A61P35/00A61P35/02
CPCA61K31/285A61K31/53A61K31/555A61K33/24A61K33/36A61K41/00A61K2300/00A61P35/00A61P35/02A61P43/00
Inventor WARRELL, RAYMOND P. JR.PANDOLFI, PIER P.GABRILOVE, JANICE L.ELLISON, RALPHSOIGNET, STEVEN
Owner MEMORIAL SLOAN KETTERING CANCER CENT
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