Compositions and methods of treating skin conditions
a technology of compositions and skin conditions, applied in the field of compositions and methods of treating skin conditions, can solve the problems of compounding not being very effective on most patients, compounding often not providing the desired clinical effect, and the therapeutic effect of these agents, however, is rather variabl
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example 2
[0049] This example compares therapeutically applied retinyl palmitate, retinoic acid, calcitriol, and combinations thereof in a cream at different concentrations with the effectiveness of the cream without any of the above compounds present in treating psoriasis. The cream used is the commercially available LUBRIDERM cream. The different compounds at different concentrations were added to the cream and mixed very well. Also, commercially available 0.005% calcipotriol (DOVONEX) and commercially available 0.005% calcipotriol supplemented with 5% retinyl palmitate were employed in treating psoriasis. Two different and distant psoriatic spots were selected on the skin of patients diagnosed with psoriasis for different treatment. Each patient used two type of creams twice a day, one cream on each selected spot.
[0050] Group I consisting of five patients applied on one selected spot (spot A) control LUBRIDERM cream and on the other selected spot (spot B) cream containing 0.1% retinoic aci...
example 3
[0062] Three patients diagnosed with eczema were treated with cream containing 0.0025% calcipotriol and 5% retinyl palmitate. A significant improvement was noticed in all three patients within 5 days and two had normal-looking skin after two weeks.
EXAMPLE 4
[0063] Various types of human melanoma, breast cancer and prostate cancer cells will be cultured according to standardized procedures. These cells will be incubated with in the presence of various concentrations of retinol, retinoic acid, retinyl esters, calcitriol or a combination thereof. Cell growth of at least some of these cells will be shown to be significantly inhibited in the presence of calcitriol and high concentrations of retinol (about 10.sup.-5M) as compared with cells incubated in the absence of the above compounds or in the presence of each of the above compounds alone.
example 4
[0064] Various types of human melanoma, breast cancer and prostate cancer cells will be cultured according to standardized procedures. These cells will be incubated with in the presence of various concentrations of retinol, retinoic acid, retinyl esters, calcitriol or a combination thereof. Some cells will also be incubated in media collected from F9 mouse teratocarcinoma cells after these F9 cells were incubated in the presence of 10.sup.-5M retinal for 12-48 hours .+-. calcitriol. Cell growth of at least some of these cell lines will be shown to be significantly inhibited in the presence of calcitriol and high concentrations of retinal (about 10.sup.-5M) or in the presence F9 cultured media containing calcitriol prior to incubation with F9 cells or after.
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