Multifunctional gold and silver core-shell nanoparticles and preparation method

Abstract

The invention relates to multifunctional gold and silver core-shell nanoparticles. The gold nanopartciles are covered by silver nano shell layers and the nanoparticles with silver core shell structures are conducted for surface modification through sulfydryl polyethylene glycol molecules; and gold nano core particles are 3 to 20 nm in size, and silver nano shells are 2 to 12 nm in size. Especially, the gold and silver core-shell nanoparticles covered by the silver nano core and shells are prepared by reducing chloroauric acid to prepare ultrafine fold nanopartciles through tetrakisphosphonium chloride activated by alkaline liquor as a reducing agent, and reducing a silver nitrate solution by nanoparticles as crystal nucleuses; and a CT (Computed Tomography) contrast medium with long-efficiency blood circulation time and an anti-infective function is obtained by performing surface modification for the gold and silver core-shell nanoparticles through polyethylene glycol modified by tail sulfhydrylation. The multifunctional gold and silver core-shell nanoparticles are uniform in particle size, good in water solubility, and free from obvious agglomeration, and the core-shell nanoparticles have stronger dissipation capacities on X rays, thereby being superior to effective developing time of CT of traditional contrast medium ioversol; and the core-shell nanoparticles effectively inhibit infection of bacteria through a contrast medium injection window.

Description

technical field [0001] The invention relates to the field of preparation of nanoparticles, in particular to an in-situ preparation method of gold-silver core-shell nanoparticles with anti-infection ability and CT imaging function. Background technique [0002] The rapid development of modern radiographic imaging technology has made the early diagnosis of many diseases (such as malignant tumors and atherosclerosis) difficult to cure by traditional medicine possible. Among them, Computed Tomography (CT) The imaging time is short (less than 10s) and the spatial resolution is high (minimum 0.5mm). Compared with magnetic resonance imaging, it can effectively reduce the impact of motion artifacts on data acquisition while ensuring image accuracy. However, due to the small difference in the X-ray dissipation capacity of human tissue and blood, the low degree of discrimination between the lesion and the surrounding normal matrix makes it difficult to effectively identify the lesion ...

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Problems solved by technology

[0005] However, the above-mentioned studies have overlooked a problem. Injection is the most commonly used method of contrast agent intervention in clinical practice, and it is inevitable to leave wounds. Statistics have found that pathogen infection at the wound or wound site is the most important pathogenic route of antibiotic-resistant bacteria. , taking methicillin-resistant Staphylococcus aureus as an example, infected patients often show strong tolerance to first-line and some second-line antibiotics, conventional treatment is usually ineffective for it, and the prognosis is poor, while both anti-infection and CT contrast agents with X-ray attenuation ability have not been reported yet

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