PH-responsive Schiff base copolymer-coated mesoporous silica drug-loaded nanoparticle as well as preparation method and application thereof

A mesoporous silica and drug-loaded nanotechnology, which is applied in the field of biomedical nanomaterials, can solve the problems of drug diffusion resistance and low drug release efficiency, achieve good biocompatibility, good drug loading capacity, and achieve rapid release effect

Active Publication Date: 2019-04-09
SOUTH CHINA UNIV OF TECH
View PDF8 Cites 31 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the drug-loading system that uses polymers to block mesoporous silica usually initiates polymerization on the surface of mesoporous silica, and uses different stimuli to induce the change of the hydrophilicity and hydrophobicity of the polymer to trigger the exposure of mesoporous pores, but the polymer does not Falling off from the surface of mesoporous silica, thus hindering the diffusion of drugs, resulting in low drug release efficiency

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • PH-responsive Schiff base copolymer-coated mesoporous silica drug-loaded nanoparticle as well as preparation method and application thereof
  • PH-responsive Schiff base copolymer-coated mesoporous silica drug-loaded nanoparticle as well as preparation method and application thereof
  • PH-responsive Schiff base copolymer-coated mesoporous silica drug-loaded nanoparticle as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] (1) Preparation of mesoporous silica containing surfactant: Take 0.2 parts by mass of CTAB, 0.7 parts by volume of NaOH solution (2M) and 96 parts by volume of water and mechanically stir for 0.5h, then quickly add 1.0 parts by volume of ethyl orthosilicate Esters, the temperature was raised to 80°C, and the reaction was continued for 2h. After the reaction was completed, it was naturally cooled to room temperature, centrifuged at 10,000 rpm, washed with water several times, and vacuum-dried at 30°C for 24 hours to obtain a white powder (MSN@CTAB).

[0070] The parts by weight of the reactants in the step (1) are as follows: 0.20 parts of CTAB; 0.06 parts of sodium hydroxide; 0.96 parts of TEOS; 98.78 parts of water.

[0071] (2) Preparation of surface aminated mesoporous silica: disperse 0.5 parts by mass of MSN@CTAB in 20 parts by volume of anhydrous toluene, N 2 Reflux at 80°C for 2 hours, add 0.75 parts by volume of silane coupling agent APTES dropwise with a syrin...

Embodiment 2

[0087] (1) Preparation of mesoporous silica containing surfactant: after mechanically stirring 0.15 parts by mass of CTAB, 3.75 parts by volume of TEOA solution and 96 parts by volume of water for 0.5 h, quickly add 1.0 parts by volume of ethyl orthosilicate, and heat up To 80 ℃, continue to react for 2h. After the reaction was completed, it was naturally cooled to room temperature, centrifuged at 10,000 rpm, washed with water several times, and vacuum-dried at 30°C for 24 hours to obtain a white powder (MSN@CTAB).

[0088] The parts by weight of the reactants in the step (1) are as follows: 0.15 parts of CTAB; 0.06 parts of TEOA; 0.95 parts of TEOS; 98.78 parts of water.

[0089] (2) Preparation of surface aminated mesoporous silica: disperse 0.6 parts by mass of MSN@CTAB in 20 parts by volume of anhydrous toluene, N 2 Reflux at 80°C for 2 hours, add 0.5 parts by volume of silane coupling agent APS dropwise with a syringe, N 2 Reflux at 80°C for 24h. After the reaction was...

Embodiment 3

[0096] (1) Preparation of mesoporous silica containing surfactant: after mechanically stirring 0.25 parts by mass of CTAB, 2.5 parts by volume of ammonia and 96 parts by volume of water for 0.5 h, quickly add 1.0 parts by volume of ethyl orthosilicate, and heat up to 80°C, continue the reaction for 2h. After the reaction was completed, it was naturally cooled to room temperature, centrifuged at 10,000 rpm, washed with water several times, and vacuum-dried at 30°C for 24 hours to obtain a white powder (MSN@CTAB).

[0097] The parts by weight of the reactants in the step (1) are as follows: 0.15 parts of CTAB; 0.06 parts of TEOA; 0.95 parts of TEOS; 98.78 parts of water.

[0098] (2) Preparation of surface aminated mesoporous silica: disperse 0.5 parts by mass of MSN@CTAB in 20 parts by volume of anhydrous toluene, N 2 Reflux at 80°C for 2 hours, add 1.0 volume parts of silane coupling agent APTES dropwise with a syringe, N 2 Reflux at 80°C for 24h. After the reaction was com...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
pore sizeaaaaaaaaaa
number average molecular weightaaaaaaaaaa
Login to view more

Abstract

The invention belongs to the technical field of biomedical nanomaterials, and discloses a pH-responsive schiff base copolymer-coated mesoporous silica drug-loaded nanoparticle as well as a preparationmethod and application thereof. The nanoparticle provided by the invention comprises a mesoporous silica nanoparticle, a drug loaded inside the mesoporous silica nanoparticle, and a polymer modifiedon a surface of the mesoporous silica nanoparticle; and the polymer modified on a surface of the mesoporous silica nanoparticle is specifically P (PEGMA-co-MAEBA) modified on the surface of the mesoporous silica nanoparticle by an imine bond. The nanoparticle material provided by the invention has good biocompatibility, and realizes controlled release of the drug by utilizing an acid-sensitive imine bond; the drug is hardly released around normal cells, but the imine bond is broken in a slightly acidic environment of tumor cells, and the polymer falls off to rapidly release the drug, thereby realizing targeted therapy for the tumors; and the nanoparticle material is applicable to the field of controlled release of drugs.

Description

technical field [0001] The invention belongs to the technical field of biomedical nanomaterials, and in particular relates to a pH-responsive Schiff-base copolymer-coated mesoporous silicon dioxide drug-loaded nanoparticle and a preparation method and application thereof. Background technique [0002] Cancer is one of the most complex and challenging diseases, which seriously threatens human life and health. Therefore, many anti-cancer drug delivery systems have been researched and developed, among which mesoporous silica nanoparticles (MSN) have large specific surface area and internal pore volume, adjustable pore size, highly ordered structure, and rich active hydroxyl groups on the surface. Modification, as well as good biocompatibility, low cost and other advantages, are particularly suitable for use as drug delivery materials. In addition, the effect of "zero leakage" can be achieved by blocking mesopores, which shows good application prospects in the field of anticanc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K47/32A61K9/51A61K31/337A61K31/4745A61K31/704A61P35/00
CPCA61K9/5146A61K31/337A61K31/4745A61K31/704A61K47/6925A61K47/6949A61P35/00
Inventor 章莉娟彭诗元袁晓哲
Owner SOUTH CHINA UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap