Long-acting medicine-loading orlon fibre capable of degrading partly, preparation and application thereof

A technology of polyacrylonitrile fiber and polyacrylonitrile, which is applied in the field of long-acting drug-loaded polyacrylonitrile fiber, can solve the problems of drug loss and incomplete drug-loaded drug release, so as to improve long-term controlled release performance and drug-loading performance. Effect

Inactive Publication Date: 2008-08-27
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the fiber is formed into a fiber in the coagulation solution, the drug crystallizes out, and the drug crystal grains will be pushed to the surface of the fiber in large quantities, resulting in the loss of the drug during the pre-stretching and thermal stretching of the fiber, and causing the initial burst release of the drug; The crystal particles are completely encapsulated by the fiber matrix, causing incomplete release of the fiber-loaded drug

Method used

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  • Long-acting medicine-loading orlon fibre capable of degrading partly, preparation and application thereof
  • Long-acting medicine-loading orlon fibre capable of degrading partly, preparation and application thereof
  • Long-acting medicine-loading orlon fibre capable of degrading partly, preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: PCL / PAN drug-loaded fiber is prepared by wet spinning

[0028] The fiber spinning solution is prepared according to the following steps: first, 10.0g drug ibuprofen and 1.0g transdermal penetration enhancer borneol are dissolved in 350mL N, N-dimethylacetamide (DMAc) at normal temperature, and then 20.0 Disperse gε-polycaprolactone (PCL), 70.0g polyacrylonitrile (PAN) fine powder in the drug solution, and finally place it in a water bath at 80°C for 24 hours under stirring conditions, and then obtain the spinning stock solution after cooling to room temperature . The drug-loaded fiber was prepared by wet method (as shown in Figure 1), dry method, dry-wet method, electrospinning, etc., and 40% DMAc aqueous solution was used as the coagulation liquid, and the nanometer drug-loaded fiber was observed with a polarizing microscope, as shown in Figure 2. Using a reading microscope, the fiber diameter was 123±16 μm.

Embodiment 2

[0029] Embodiment 2: Dry spinning prepares PCL / PAN drug-loaded fiber

[0030] The spinning dope was prepared according to Example 1, and the drug-loaded fiber was prepared by a dry process.

Embodiment 3

[0031] Embodiment 3: Preparation of PCL / PAN drug-loaded fiber by dry-wet spinning

[0032] The spinning dope was prepared according to Example 1, and the drug-loaded fiber was prepared by a dry-wet process.

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Abstract

The invention relates to a part-degradable long-acting drug loading polyacrylonitrile fiber and application and a method thereof, which takes polyacrylonitrile as a substrate, polymerized substance and active components which are degradable, soluble and can be swelled are loaded in the fiber, the fiber can control the active components to release slowly and chronically through the stepwise degradation, dissolving or swelling of the polymerized substance, the drug loading fiber can be prepared by adopting various spinning methods, spinning dope is prepared by blending, and spinning liquid comprises the polyacrylonitrile, the active components, the degradable polymerized substance, percutaneous absorption permeation accelerator and the like. The fiber can further be used for preparing multipurpose medicinal textiles, health care textiles, aromatic textiles, drug shims, medicine stickings and treating of skin disease, and the controlled release drug delivery system which carries out the systemic drug through skin or the inhaling mode.

Description

technical field [0001] The invention belongs to the field of drug carriers, in particular to a partially degradable long-acting drug-loaded polyacrylonitrile fiber, its preparation and application. Background technique [0002] The use of textiles as drug carriers has a long history. In ancient my country, traditional Chinese medicine was packed in cloth bags, which were sewn and worn to drive away evil spirits and avoid pollution, or boiled plasters, attached to fabrics and pasted on specific acupoints on the body surface to make medicines Penetrating into the body, it is more effective than taking medicine for certain diseases. Textiles are closely related to human beings. If they are endowed with the function of loading drugs, they will be able to treat diseases without injections and medicines, facilitate treatment, reduce side effects, and improve drug safety and patient tolerance. [0003] With the development of modern science and technology, especially materials scie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F6/54D01F1/10A61K47/38A61M37/00
Inventor 朱利民余灯广申夏夏朱思君
Owner DONGHUA UNIV
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