Long-acting medicine-loading orlon fibre capable of degrading partly, preparation and application thereof
A technology of polyacrylonitrile fiber and polyacrylonitrile, which is applied in the field of long-acting drug-loaded polyacrylonitrile fiber, can solve the problems of drug loss and incomplete drug-loaded drug release, so as to improve long-term controlled release performance and drug-loading performance. Effect
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Embodiment 1
[0027] Embodiment 1: PCL / PAN drug-loaded fiber is prepared by wet spinning
[0028] The fiber spinning solution is prepared according to the following steps: first, 10.0g drug ibuprofen and 1.0g transdermal penetration enhancer borneol are dissolved in 350mL N, N-dimethylacetamide (DMAc) at normal temperature, and then 20.0 Disperse gε-polycaprolactone (PCL), 70.0g polyacrylonitrile (PAN) fine powder in the drug solution, and finally place it in a water bath at 80°C for 24 hours under stirring conditions, and then obtain the spinning stock solution after cooling to room temperature . The drug-loaded fiber was prepared by wet method (as shown in Figure 1), dry method, dry-wet method, electrospinning, etc., and 40% DMAc aqueous solution was used as the coagulation liquid, and the nanometer drug-loaded fiber was observed with a polarizing microscope, as shown in Figure 2. Using a reading microscope, the fiber diameter was 123±16 μm.
Embodiment 2
[0029] Embodiment 2: Dry spinning prepares PCL / PAN drug-loaded fiber
[0030] The spinning dope was prepared according to Example 1, and the drug-loaded fiber was prepared by a dry process.
Embodiment 3
[0031] Embodiment 3: Preparation of PCL / PAN drug-loaded fiber by dry-wet spinning
[0032] The spinning dope was prepared according to Example 1, and the drug-loaded fiber was prepared by a dry-wet process.
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