Method for preparing mesoporous silica nanoparticles with coumarin optically controlled molecular switch by thiol-ene click chemistry

Abstract

The invention provides a method for preparing mesoporous silica nanoparticles with a coumarin optically controlled molecular switch by thiol-ene click chemistry. The method comprises the following steps: a coumarin derivative whose side chain contains a double bond is dissolved in a certain solvent, siloxane containing a mercapto group is added, a reaction is carried out in a proper condition with initiation of light or a free radical generating agent, and a silanization reagent containing a coumarin ring structure is prepared. The silanization reagent is grafted to mesoporous silica nanoparticles, and the mesoporous silica nanoparticles with the coumarin optically controlled molecular switch are obtained. The mesoporous silica nanoparticles with the coumarin optically controlled molecular switch are used for controlled release of medicaments.

Description

technical field [0001] The invention belongs to the field of drug controlled release carrier materials, and in particular relates to a method for preparing mesoporous silicon dioxide nanoparticles with coumarin light-controlled molecular switches by a thiol-ene click chemistry method. Background technique [0002] In order to realize the efficient utilization of drug molecules and minimize their side effects, people hope that drug molecules can be released at specific time points and in specific tissues or organs, thus the concept of controlled release is proposed. At present, the common method of drug controlled release is mainly to load drug molecules through special carrier materials, and let the carrier materials loaded with drug molecules release drug molecules only under specific stimulation signals. Such specific stimulation signals can be physical signals such as temperature, magnetic field, and light, or chemical signals such as pH, ionic strength, and specific mole...

AI Technical Summary

Problems solved by technology

[0006] However, the traditional preparation method of mesoporous silica nanoparticles with coumarin light-controlled molecular switches needs to use triethoxysilane and platinum-containing noble metal catalysts. The main disadvantages are: triethoxysilane is not only relatively expensive High, and it is unstable and extremely flammable, which is not convenient for transportation, storage and large-scale application; and due to its instability, the requirements for reaction conditions are relatively harsh, the yield is difficult to guarantee, and the success rate of the reaction is low ; and the use of noble metal catalysts increases production costs and limits the promotion of this technology

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