Preparation of biomedical amino acid-polyether-polyester triblock copolymer

Abstract

The invention belongs to the technical field of medical biological materials, and particularly relates to a preparation method of a biomedical amino acid-polyether-polyester triblock copolymer. The method comprises the following steps of: initiating lactone ring opening polymerization under a vacuum condition to prepare a polyether-polyester copolymer, and adding a polymer, amino acid, a catalyst and a solvent into a reaction kettle; and reacting to obtain an amino acid-polyether-polyester triblock copolymer, and removing water and the solvent left in a polymerization system to obtain the amino acid-polyether-polyester triblock copolymer. The method is easy to operate and is practicable; reaction conditions are easy to control; and the obtained copolymer has a stable structure, and can be used for entrapping slightly-soluble medicaments to meet the requirements of clinical treatment.

Description

technical field [0001] The invention belongs to the field of synthesis of medical biopolymer materials, in particular to the preparation of an amino acid-polyether-polyester triblock copolymer. Background technique [0002] In recent years, nanotechnology-based polymer micelles have received extensive attention. Compared with other drug carriers, polymer nanomicelle has good encapsulation and stable structure in blood; it is resistant to dilution and has long circulation characteristics; moderate particle size, strong penetration ability and certain targeting Sex; increase the solubility of drugs, and reduce the adverse reactions of poorly soluble drugs caused by solvents, etc. [0003] So far, nanopolymer micelles are mainly diblock copolymers of polyether and polyol. This copolymer has the above-mentioned polymer properties, but there are also many shortcomings, mainly in the structure after encapsulating the drug. Not very stable, the main connection method between mice...

AI Technical Summary

Problems solved by technology

[0003] So far, nanopolymer micelles are mainly diblock copolymers of polyether and polyol. This copolymer has the above-mentioned polymer properties, but there are also many shortcomings, mainly in the structure after encapsulating the drug. Not very stable, the main connection method between micelles and drugs is that the hydrophobic end and the insoluble drug form a self-assembled inclusion complex. In order to ensure the size of the particle, the hydrophilic end should not be too long, which will easily expose the hydrophobic end in the encapsulation structure , will cause the drug to separate and precipitate from the hydrophobic end. To solve this problem, CN 96197134.7 discloses a technology based on ordinary micelles to modify the hydrophilic end with end groups. CN 200580018124.1 discloses a technology to add nucleic acid As a stabilizer and other methods to prevent the premature precipitation of drugs

It should be noted that these methods do not change the structure of the micelle itself, so the early precipitation of the encapsulated drug is still not a good solution