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Coated barium sulfate nanoparticle, preparation method and use thereof

A barium sulfate and nanoparticle technology, applied in the field of nanomaterials, can solve the problems of infection, PMMA mechanical properties and biocompatibility decline, and achieve the effects of enhanced developing performance, excellent drug loading performance and good application prospects

Inactive Publication Date: 2019-01-18
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to enhance the developing effect of PMMA bone cement, a large amount of BaSO is usually added to it 4 , therefore, the mechanical properties and biocompatibility of PMMA will decrease, and it will also cause infection

Method used

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  • Coated barium sulfate nanoparticle, preparation method and use thereof
  • Coated barium sulfate nanoparticle, preparation method and use thereof
  • Coated barium sulfate nanoparticle, preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 1. Add 5.2g BaCl 2Dissolve in 50mL deionized water, then mix with 50mL aqueous solution containing 3wt% polyvinyl alcohol, add 25mL containing 3.3g (NH 4 ) 2 SO 4 After the dropwise addition is complete, continue to stir for 3 minutes, then let it stand at room temperature for 5 hours, and centrifuge to obtain BaSO 4 The precipitation was washed three times with deionized water, dried at 80°C for 2h, and the BaSO4 precipitate was calcined in a muffle furnace at 600°C for 4h to obtain porous barium sulfate nanoparticles.

[0041] 2. Prepare 10mM Na 2 CO 3 / NaHCO 3 solution and 0.2M silver ammonia solution.

[0042] 3. Dissolve 100mg I-CD in 1mL N,N-dimethylformamide, then add to 150mL Na containing 300mgDOPA, pH=5, concentration 10mmoL / L 2 CO 3 / NaHCO 3 In the solution, 3g BaSO 4 Add 150mL of 0.2M silver ammonia solution, mix the two solutions under magnetic stirring, react at 25°C for 8h, then centrifuge to remove the supernatant, wash the precipitate with dei...

Embodiment 2

[0044] 1. Add 5.2g BaCl 2 Dissolve in 25mL deionized water, then mix with 25mL aqueous solution containing 1wt% polyvinyl alcohol, add 25mL containing 3.3g (NH 4 ) 2 SO 4 After the dropwise addition is complete, continue to stir for 3 minutes, then let it stand at room temperature for 5 hours, and centrifuge to obtain BaSO 4 Precipitated, washed three times with deionized water, dried at 80 °C for 2 h, and BaSO 4 The precipitate was calcined at 600° C. for 4 h in a muffle furnace to obtain porous barium sulfate nanoparticles.

[0045] 2. Prepare 20mM Na 2 CO 3 / NaHCO 3 solution and 0.4M silver ammonia solution.

[0046] 3. Dissolve 200mg I-CD in 1mL N,N-dimethylformamide, then add to 150mL Na 2 CO 3 / NaHCO 3 In the solution, 3g BaSO 4 Add 150mL of 0.4M silver ammonia solution, mix the two solutions under magnetic stirring, react at 25°C for 8h, then centrifuge to remove the supernatant, wash the precipitate with deionized water several times, and obtain multifunctio...

Embodiment 3

[0048] 1. Dissolve 20.8g BaCl2 in 50mL deionized water, then mix with 50mL aqueous solution containing 7wt% polyvinyl alcohol, add 25mL containing 13.2g (NH 4 ) 2 SO 4 After the dropwise addition is complete, continue to stir for 3 minutes, then let it stand at room temperature for 5 hours, and centrifuge to obtain BaSO 4 Precipitated, washed three times with deionized water, dried at 80 °C for 2 h, and BaSO 4 The precipitate was calcined at 600° C. for 4 h in a muffle furnace to obtain porous barium sulfate nanoparticles.

[0049] 2. Prepare 30mM Na 2 CO 3 / NaHCO 3 solution and 1M silver ammonia solution.

[0050] 3. Dissolve 500mg I-CD in 2mL N,N-dimethylformamide, then add to 150mL Na 2 CO 3 / NaHCO 3 In the solution, 9g BaSO 4 Add 150mL of 1M silver ammonia solution, mix the two solutions under magnetic stirring, react at 25°C for 8h, then centrifuge to remove the supernatant, wash the precipitate with deionized water several times, and obtain coated barium sulfat...

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Abstract

The invention relates to the technical field of materials, and discloses a coated barium sulfate nanoparticle used for bone cement developer. The coated barium sulfate nanoparticle mainly comprises porous barium sulfate nanoparticles coated on the surface of the porous barium sulfate nanoparticles and loaded with hexa (6-iodo-6-deoxy)-[alpha]-Polydopamine (PDA) coatings of cyclodextrin (I-CD) andsilver (Ag) were prepared to prepare barium sulfate nanoparticles. The invention discloses a coating barium sulfate nanoparticle, which is prepared by adding the coating barium sulfate nanoparticle into polymethyl methacrylate bone cement as a developer, and the preparation method and the use thereof show excellent X-ray diffraction characteristics. The preparation method is simple and can be usedas a new type of developer in bone cement because of its developmental properties, antibacterial properties, biocompatibility, mechanical properties and drug loading and release properties.

Description

technical field [0001] The invention relates to the technical field of nanomaterials, in particular to a multifunctional coating-type barium sulfate nanoparticle used as a bone cement developer and a preparation method. Background technique [0002] In the past few decades, polymethyl methacrylate (PMMA) bone cement has been widely used in orthopedics for prosthetic replacement and adhesive due to its injectability, high strength and good biocompatibility. attached materials. In the process of joint replacement surgery and minimally invasive treatment, it is very necessary to expose the PMMA bone cement and the lesion to perform surgery under the condition of image assistance. Although PMMA bone cement has very good mechanical properties, the X-ray imaging performance of PMMA bone cement is very poor because it contains atoms with low electron density such as carbon, hydrogen, and oxygen. Therefore, it is very necessary to add contrast agent to PMMA bone cement. [0003] ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61L27/02A61L27/34A61L27/30
CPCA61L27/025A61L27/306A61L27/34A61L27/50A61L2300/104A61L2300/404A61L2300/624A61L2300/802A61L2400/12C08L79/04C08L5/16
Inventor 李斌李家颖韩凤选杨惠林
Owner SUZHOU UNIV
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