63results about How to "Moderate release rate" patented technology

The invention discloses an albumin conjugated taxol nanoparticle freeze-dried preparation and a preparation method thereof. The preparation consists of the following components in percentage by weight: 0.1-2 percent of sterile taxol (nanoscale), 0.2-60 percent of human serum albumin (nanoscale), 0.2-60 percent of a surfactant, 0.2-30 percent of an oil phase, 0.2-60 percent of a freeze-dried framework agent, 0.1-5 percent of a pH regulating agent and 0.1-5 percent of a stabilizing agent. The invention provides an albumin conjugated taxol nanoparticle freeze-dried preparation, which can be used for enhancing the stability and safety of taxol, prolonging the medicament effect and enhancing the targeting capability. Albumin is taken as a carrier and an appropriate mixture ratio is selected, so that medicaments can be protected from being influenced by the environment, active ingredients are isolated, volatility and toxicity are lowered, an appropriate medicament releasing speed can be obtained, a slow and durable action is realized, and untoward effects are reduced.

The invention discloses a silk-fibroin multilayer composite micro-needle and a preparation method thereof and belongs to the field of micro-needle transdermal drug release. The preparation method includes: preparing an inner-layer micro-needle array, using a layer-by-layer composite solidification method to soak the micro-needle into a silk fibroin solution and then dry and solidify the micro-needle, and repeating the soaking and solidification step to obtain the multilayer composite micro-needle. The silk-fibroin multilayer composite micro-needle has the advantages that the multilayer composite micro-needle is formed by silk fibroin layers loaded with identical or different drugs, and multilayer superposition in a certain needle length range can be achieved; the superposition of differentlayers is achieved in the single needle body, and the varieties of loadable drugs are increased; meanwhile, by regulating the structure of each silk fibroin layer, the crystalline structure of the silk fibroin is changed, different release speed of different layers can be achieved, and the micro-needle is applicable to the treatment of diseases which need composite drug use; the micro-needle andrelease the drugs in a layered manner during puncture, the outer layer dissolves to fast release the drug, the inner layer swells to slowly release the drug, and balanced drug delivery in a long timecan be achieved.

Provided are recombination cattle alkaline fibroblast growth factor gel and preparation method of the same. Components and dosage of the gel are as follows: 10000 to 30000 IU of recombination cattle alkaline fibroblast growth factors, 0.5 to 2.5 mg of protein protective agent, 10 to 30 mg of gel matrix, a right amount of pH regulators and 5ml of water for injection. The gel agent is simple in accessory, can reach good stability and releasing effect and is capable of treating various surfaces of wound caused by scalding and trauma.

The present invention relates to a technique for preparing mancozeb, concretely relates to a technique for preparing mancozeb. The technique for preparing mancozeb according to the invention complexes washed, dehydrated maneb with zinc salt, which comprises steps of: (a) refining maneb, zinc salt and reaction adjuvant; (b) abrading slurry obtained in last step in the abrading machine, and generating complex reaction of the material during the abrading process to obtain full complexing form mancozeb. During the abrading process, the maneb generates complex reaction with zinc ion, the ratio of generated complexing form mancozeb in the complex reaction is effectively improved relatively along with the granularity of material is reduced, until full complexing form mancozeb is obtained. The invention integrates the abrading process and the complex reaction process, which shortens the technique flow and production efficiency is high.

The invention provides a composite coating having antibacterial performance and biocompatibility. The composite coating includes an antibacterial coating and a biocompatibility coating, wherein the antibacterial coating is 2-1000nm thick; and the biocompatibility coating is 2-500nm thick. With the application of a mode of combining the antibacterial coating and the biocompatibility coating, the service life of the coating (the composite coating) is prolonged; the composite coating, which is simple in process, can be continuously and rapidly prepared by a large area; a better antibacterial effect can be achieved, so that antibacterial elements can be released at moderate speed; the biocompatibility coating, under the conditions, can avoid influence to release of antibacterial elements and development of antibacterial performance; and therefore, the composite coating is an ideal coating of implantable medical apparatuses.

The invention provides a targeting hybrid nano-system, a preparation method thereof and an application. The targeting hybrid nano-system comprises lipid bilayer nanospheres, amphipathic polymeric nano-particles, targeting polypeptides and/or antibodies and different medicines, wherein the lipid bilayer nanospheres wrap the amphipathic polymeric nano-particles, the targeting polypeptides and/or antibodies are connected on the surfaces of the lipid bilayer nanospheres, and the amphipathic polymeric nano-particles and the lipid bilayer nanospheres wrap the different medicines. The prepared targeting hybrid nano-system has targeting according to tumor microenvironments and has a space structure of 'a large sphere wrapping a small sphere', small nano-particles in the system have penetrating capacity for deep tumor tissues, the targeting hybrid nano-system can simultaneously wrap various different water-soluble medicines, and multi-drug combination treatment targeting tumor tissues is achieved, so that the targeting hybrid nano-system has the advantages of good specificity and drug loaded effect, moderate drug release speed, multi-drug combination and multi-targeted treatment.

The invention discloses a method for screening an aptamer via a high performance liquid chromatography, the aptamer and an application. The method for screening aptamers via high performance liquid chromatography comprises the following steps: screening a nucleic acid library of aptamers combined with docetaxel specificity from a random library RS36; screening the nucleic acid library by the high performance liquid chromatography to obtain the aptamer. In the high performance liquid chromatography, the stationary phase is an octadecyl bonded silica gel chromatographic column, the moving phase adopts water-acetonitrile gradient elution, the detection wavelength is 260nm and the detector is a diode array detector. The aptamer screened according to the high performance liquid chromatography has the advantages of being bonded with high specificity and high appetency of docetaxel, being free of immunogenicity, being capable of carrying out chemical synthesis and being good in biocompatibility, small in molecular weight, stable and easy to store, and can be applied to drug carriers, drug separation and purification, and preparation of docetaxel detection probes or target probes.

The invention relates to a rice slow-release fertilizer and preparation and application methods thereof, the rice slow-release fertilizer is spherical particles, and sequentially comprises a nutrientcore, an inner coating, a fertilizer layer and an outer coating from inside to outside; the nutrient core comprises the following main components: nitrogen-phosphorus-potassium or a nitrogen-potassiumcompound fertilizer, a trace element fertilizer, a silicon fertilizer, a calcium fertilizer, a magnesium fertilizer and a sulfur fertilizer; the inner coating comprises the following main components:sodium alginate, carboxymethyl chitosan and a nitrification inhibitor; the fertilizer layer comprises the following main components: an organic fertilizer, ammonium chloride and a microbial agent; and the outer coating comprises the following main components: attapulgite and ethyl cellulose. The invention also discloses a preparation method and an application method of the rice slow-release fertilizer. The rice slow-release fertilizer disclosed by the invention is rich and diverse in fertilizer, matched with rice growth requirements, appropriate in release speed and high in fertilizer utilization rate. The slow-release fertilizer prepared by the method is uniform in particles, simple in process, low in cost and suitable for industrial production. According to the application method, fertilizer utilization is efficient and reasonable, the yield is guaranteed, and environmental pollution and waste are reduced.

The invention belongs to the technical field of high polymer materials, and particularly relates to closed hydrogel as well as a preparation method and application thereof. Raw materials for preparingthe closed hydrogel comprise a first component and a second component, wherein the first component comprises a compound A and a compound B; the compound A is a derivative of multi-arm polyethylene glycol, and the compound B is multi-arm copolyester of glycidyl isopropyl ether and ethyl glycidyl ether; and the second component comprises oligopeptide or a derivative thereof. According to the hydrogel, the swelling rate of the hydrogel can be effectively reduced by selecting high molecular weight compounds in the gel components and matching the first component with the second component.

The invention relates to a novel matrix sustained-release tablet containing loxoprofen sodium, in particular to a locoprofen sodium matrix sustained-release tablet with a regulation layer, which is capable of stably releasing for 8 hours, good in releasing effect, simple in process and low in cost.

The invention discloses a controlled-release fertilizer for sugarcane and a preparation method thereof, belonging to the technical field of preparation of fertilizers. The controlled-release fertilizer for the sugarcane comprises the following raw materials by weight: 60 to 140 parts of a packaging material and 180 to 1200 parts of fertilizer granules. The controlled-release fertilizer for the sugarcane is prepared by comprising the steps of mixing, stirring, granulating, drying, cooling, packaging, etc. According to the invention, controlled-release rate of the fertilizer is moderate and stable; nutrition is balanced; the loss rate of the fertilizer can be effectively reduced; utilization efficiency of the fertilizer is improved; rapid and healthy growth of the sugarcane is promoted; and the yield of the sugarcane is increased by 12.4% to 13.6%, and the content of sucrose is increased by 0.32% to 0.4%.

The invention relates to a vitamin C smicrocapsule flour improver and a preparation method thereof. The wall material of the flour improver is a mixed type wall material containing starch, stearic acid monoglyceride and hardened oil, and the bag core substance is vitamin C. The stearic acid monoglyceride and the hardened oil are mixed and then melted, then the starch and the vitamin C are added in the molten mass and evenly stirred to obtain the finished product by freezing, granulating and crushing. The smicrocapsule flour improver has the advantages of good stability, proper release rate, security, no foreign flavor and high utilization ratio of the vitamin C. In the method for preparing the vitamin C smicrocapsule flour improver, the realized cladding rate is up to 90 percent, no solvent is required to be used, the environmental pollution phenomenon does not exist, the process is simple and feasible and the cost is low.

The invention discloses a controlled-release fertilizer for a tea tree and a preparation method thereof, belonging to the technical field of preparation of fertilizers. The controlled-release fertilizer for the tea tree comprises the following raw materials by weight: 60 to 140 parts of a packaging material and 200 to 1400 parts of fertilizer granules. The controlled-release fertilizer for the tea tree is prepared by comprising the steps of mixing, stirring, granulating, drying, cooling, packaging, etc.. According to the invention, controlled-release rate of the fertilizer is moderate and stable; nutrition is balanced; the loss rate of the fertilizer can be effectively reduced; utilization efficiency of the fertilizer is improved; healthy growth of the tea tree is promoted; and an average yield of tea leaves is increased by 14.8% to 15.6%.

The invention discloses feed capable of promoting rapid weight increment of chickens. The feed is prepared from the following raw materials in parts by weight: 30-40 parts of fish meal, 20-25 parts of soybean meal, 10-20 parts of water hyacinths, 20-30 parts of wheat flour, 1-2 parts of shell powder, 2-5 parts of feed-grade calcium hydrogen phosphate, 1-3 parts of medical stone powder, 1-2 parts of zeolite powder immersed with vinegar, 0.5-2 parts of fish oil, 0.5-1.2 parts of soybean oil, 0.5-0.8 part of table salt, 1-3 parts of fresh ginger powder, 0.2-0.5 part of choline chloride, 0.5-1 part of vitamin, 0.5-1 part of carnitine, 1-3 parts of a mycotoxin adsorbent, 0.1-0.2 part of capsule covered L-lysine, 0.3-0.6 part of D-methionine, 0.2-0.5 part of L-methionine and 0.5-0.8 part of L-tryptophan, wherein in the soybean meal, the content of crude fibers is more than 55wt%; and L-carnitine accounts for 45wt%-55wt% of the carnitine. With the adoption of the feed provided by the invention, the utilization rate of the feed is improved, the growth of the chickens is remarkably promoted, and wastes on water also can be circularly utilized.

The invention discloses an amphiphilic polypeptide, a heterozygous liposome and its preparation method, and a drug-loaded heterozygous liposome and its preparation method. The invention discloses the amphiphilic polypeptide with enzyme responsiveness. The amphiphilic polypeptide is shown in the structural formula (1) and in the structural formula (1), R represents amino acid residue, n is an integer of 4-10, n R groups are same or different and the n R groups form at least one polypeptide fragment hydrolyzed by an enzyme. The invention also provides the heterozygous liposome with enzyme responsiveness and a preparation method thereof. The preparation method comprises that the amphiphilic polypeptide contacts with phosphatide. The invention also provides the drug-loaded heterozygous liposome with enzyme responsiveness and its preparation method. The preparation method comprises that the amphiphilic polypeptide, a drug compound and phosphatide contacts. The drug carrier prepared from the amphiphilic polypeptide with enzyme responsiveness has the advantages of high specificity, good drug carrying effects, a moderate drug release rate and good stability. The preparation methods have simple processes and have low costs.

The invention relates to a method for producing an active phosphate fertilizer by using by-product fluosilicic acid, which comprises the following steps: 1) preparing rock phosphate powder: grinding and crushing the low grade phosphate rock in an air swept mill, preparing the rock phosphate powder with granularity of 80-200 meshes; and 2) mixing: sending the prepared rock phosphate powder in a muller mixer, stirring and grinding, adding water through an atomization nozzle; then adding fluosilicic acid with concentration of more than 20% in the humidified rock phosphate powder through the atomization nozzle; adding an activator through the atomization nozzle finally; continuously rolling, mixing, homogenizing and crushing the materials in the muller mixer to obtain the finished product. The method for producing the active phosphate fertilizer by using by-product fluosilicic acid has the advantages that 1) the original low grade phosphate rock with non-industrial value or less value can be utilized; and 2) the method uses an appropriate solid liquid ratio of the rock phosphate powder and the activator, the production process is simple, the investment is small, the aging process of a traditional phosphate fertilizer production is not required, the uncontrollable discharge of fluorine containing gas during the production process is not generated, and no pollution is generated.

The invention discloses a lychee release-control fertilizer and a preparation method thereof and belongs to the technical field of fertilizer preparation. The lychee release-control fertilizer comprises, by weight, 60 to 120 parts of coating material and 200 to 1200 parts of fertilizer granules; the lychee release-control fertilizer is prepared by steps of mixing, granulating, drying, cooling, coating and the like. The lychee release-control fertilizer has a moderate and stable release control speed, has balanced nutrition and is effective in reducing its loss rate, improving its availability and promoting healthy growth of lychee, lychee yield is averagely increased by 11.6% to 12.8%, and lychee sugar content is increased by 0.32% to 0.39%.

The invention discloses a nifedipine sustained-release tablet and a preparation method thereof. The nifedipine sustained-release tablet is a double-layer tablet, wherein the outer-layer tablet is prepared from the following raw materials: nifedipine, microcrystalline cellulose, spray-dried lactose, sodium dodecyl sulfate, copovidone, superfine silica powder and magnesium stearate by using a direct powder compression method; and the inner-layer tablet is prepared from the following raw materials: nifedipine, lactose, pregelatinized starch, hydroxypropyl cellulose, sodium alginate, potassium alginate, povidone, PEG6000, polyvinylpyrrolidone and magnesium stearate. The preparation method comprises the steps of preparing a nifedipine dispersoid from nifedipine, povidone and PEG6000 by using a solvent evaporation method; and then, carrying out wet granulation on the nifedipine dispersoid and other raw materials to prepare the inner-layer tablet. The outer-layer tablet of the nifedipine sustained-release tablet is prepared by using the direct powder compression method, so that disintegration is high, and the required blood concentration is rapidly reached within short time; and the inner-layer tablet formed by compounding the hydroxypropyl cellulose, sodium alginate and potassium alginate is used as a gel sustained-release framework and can be completely released within 24h.

The invention discloses an antibacterial and corrosion-resistant nano-composite coating strongly combined with an implant and a preparation method thereof. The nano-composite coating comprises a corrosion-resistant combined layer and an antibacterial layer, the antibacterial layer is an independent nano-zinc oxide coating, or an independent graphene oxide coating, or a nano-zinc oxide and graphene oxide combined coating. The method comprises the following steps: (1) preparing a PDA coating on the surface of the implant; (2) preparing a GO coating on the surface of the implant obtained in the step (1) to obtain a polydopamine-graphene oxide nano composite coating which is strongly combined with the implant and has antibacterial and corrosion-resistant properties; (3) preparing a nano ZnO coating on the surface of the implant obtained in the step (1) to obtain a polydopamine-nano zinc oxide nano composite coating which is strongly combined with the implant and has antibacterial and corrosion-resistant properties; and (4) preparing the GO coating on the surface of the implant obtained in the step (3) to obtain the polydopamine-nano zinc oxide-graphene oxide nano composite coating which is strongly combined with the implant and has antibacterial and corrosion-resistant properties.

The invention discloses a disinfecting and smell-removing steam cleaning bag for a microwave oven. The cleaning bag comprises a solution, a cleaning cloth and an outer material. The cleaning cloth is dipped with the solution. The outer material contains the cleaning cloth dipped with the solution. The solution comprises 5-20% by weight of an ethanol/dipropylene glycol butyl ether complex and 0-5% by weight of an auxiliary agent, with the balance being water, wherein the weight ratio of the ethanol to the dipropylene glycol butyl ether in the complex is 5:1-15:1. The invention also discloses a method of cleaning the microwave oven.