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Antibacterial and corrosion-resistant nano-composite coating strongly combined with implant and preparation method thereof

A nano-composite coating and implant technology, applied in the direction of coating, metal material coating process, prosthesis, etc., can solve the problems of easy to cause drug resistance, limited antibiotic action time, etc., and achieve strong activity and moderate release speed. , good antibacterial effect

Pending Publication Date: 2021-11-19
LANZHOU UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Bactericidal effects are achieved by introducing antibiotics into the surface of titanium alloys, but antibiotics have limited action time and are prone to drug resistance

Method used

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  • Antibacterial and corrosion-resistant nano-composite coating strongly combined with implant and preparation method thereof
  • Antibacterial and corrosion-resistant nano-composite coating strongly combined with implant and preparation method thereof
  • Antibacterial and corrosion-resistant nano-composite coating strongly combined with implant and preparation method thereof

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preparation example Construction

[0020] The preparation method of the nano-composite coating with strong combination with the implant body and antibacterial and corrosion resistance of the present invention comprises the following steps:

[0021] Step (1) preparing a PDA coating on the surface of the implant;

[0022] Step (2) Prepare a GO coating on the surface of the implant obtained in step (1), and obtain a polydopamine-graphene oxide nanocomposite coating that is strongly combined with the implant and has antibacterial and corrosion resistance properties, that is, GP nanocomposite coating;

[0023] Step (3) Prepare a nano-ZnO coating on the surface of the implant obtained in step (1), and obtain a polydopamine-nano-zinc oxide nanocomposite coating that is strongly combined with the implant and has antibacterial and corrosion resistance properties, that is, ZP nano Composite coating;

[0024] Step (4) Prepare a GO coating on the surface of the implant obtained in step (3), and obtain a polydopamine-nano...

Embodiment 1

[0089] Nanocomposite coating of the present invention, the flow chart of its preparation method is as figure 1 As shown, the details are as follows:

[0090] (1) Use the polished titanium alloy (Ti6Al4V) as the substrate, and ultrasonically clean it in acetone, absolute ethanol, and deionized water for 15 minutes;

[0091] (2) Prepare a PDA coating on the surface of the titanium alloy substrate obtained in step (1) by a solution oxidation method. The dosage of trishydroxyaminomethane hydrochloride is 0.0788g, the dosage of dopamine hydrochloride is 0.1000g, and the pH value of the solution environment is 8.5, the reaction temperature is 25°C, the thickness of the PDA layer is 50nm; see the antibacterial effect of the PDA coating figure 2 ; Corrosion resistance see Figure 7~Figure 12 shown.

[0092] (3) On the surface of the PDA coating obtained in step (2), GO powder was prepared by using the improved Hummers method and freeze-drying treatment. First, the product obtained...

Embodiment 2

[0096] Nanocomposite coating of the present invention, the flow chart of its preparation method is as figure 1 As shown, the details are as follows:

[0097] (1) Use the polished titanium alloy (Ti6Al4V) as the substrate, and ultrasonically clean it in acetone, absolute ethanol, and deionized water for 15 minutes;

[0098] (2) adopt and embodiment 1 identical mode to prepare PDA coating;

[0099] (3) On the surface of the PDA coating obtained in step (2), a nano-ZnO coating was prepared by a seedless hydrothermal method, and 0.2975g Zn(NO 3 ) 2 ·6H 2 O and 0.1402g of hexamethylenetetramine (HMT) powder were respectively dissolved in 100mL of deionized water to form a solution with a concentration of 0.01mol / L;

[0100] (4) The solution obtained in step (3) was poured into Zn(NO 3 ) 2 Stir and mix the solution evenly, then put it into the titanium alloy substrate coated with PDA coating, and then rapidly raise the temperature to the preset temperature of 90°C. As the temp...

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Abstract

The invention discloses an antibacterial and corrosion-resistant nano-composite coating strongly combined with an implant and a preparation method thereof. The nano-composite coating comprises a corrosion-resistant combined layer and an antibacterial layer, the antibacterial layer is an independent nano-zinc oxide coating, or an independent graphene oxide coating, or a nano-zinc oxide and graphene oxide combined coating. The method comprises the following steps: (1) preparing a PDA coating on the surface of the implant; (2) preparing a GO coating on the surface of the implant obtained in the step (1) to obtain a polydopamine-graphene oxide nano composite coating which is strongly combined with the implant and has antibacterial and corrosion-resistant properties; (3) preparing a nano ZnO coating on the surface of the implant obtained in the step (1) to obtain a polydopamine-nano zinc oxide nano composite coating which is strongly combined with the implant and has antibacterial and corrosion-resistant properties; and (4) preparing the GO coating on the surface of the implant obtained in the step (3) to obtain the polydopamine-nano zinc oxide-graphene oxide nano composite coating which is strongly combined with the implant and has antibacterial and corrosion-resistant properties.

Description

technical field [0001] The invention belongs to the technical field of metal material surface modification, and relates to the preparation technology of nanocomposite coating. Background technique [0002] With the increasing hard tissue damage caused by diseases or accidental injuries, titanium alloys, as artificial bone substitutes, have attracted great attention in the field of implant medicine due to their excellent biocompatibility and good mechanical properties. The development of additive manufacturing technology has made it possible to process porous titanium alloys, and this technology has also effectively solved the problem of "stress shielding" existing in titanium alloy implants. However, as a permanent hard tissue implant, titanium alloy must also take into account its comprehensive properties such as antibacterial, corrosion resistance, and osteocyte growth promotion while considering its mechanical properties. Surface modification coating design plays an impo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/30A61L27/06A61L27/50A61L27/54C23C26/00
CPCA61L27/34A61L27/306A61L27/303A61L27/06A61L27/50A61L27/54C23C26/00A61L2300/404A61L2420/02A61L2420/08A61L2420/06A61L2400/12A61L2300/102A61L2300/108A61L2300/606A61L2300/602C08L79/02
Inventor 胡勇胡永淇李申申张会莹张昊褚成王力华
Owner LANZHOU UNIVERSITY OF TECHNOLOGY
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