Recombination cattle alkaline fibroblast growth factor gel

A fibroblast and growth factor technology, applied in the field of recombinant bovine basic fibroblast growth factor gel and its preparation, can solve the problems of difficult preparation stability and large dosage in the production process, and achieve the promotion of wound healing with low dosage , Ease of use

Inactive Publication Date: 2012-12-19
ZHUHAI ESSEX BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But above-mentioned disclosed two kinds of gels have all used many kinds, the adjuvant that consumption is big, bring unpredictable difficulty to production process and preparation stability

Method used

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  • Recombination cattle alkaline fibroblast growth factor gel
  • Recombination cattle alkaline fibroblast growth factor gel
  • Recombination cattle alkaline fibroblast growth factor gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] prescription:

[0039]

[0040] The specific preparation method is:

[0041] Swell the carbomer with an appropriate amount of water for injection, adjust the pH value to form a transparent gel, then autoclave at 121°C, and cool it for later use; dissolve the recombinant bovine basic fibroblast growth factor and human serum albumin in In an appropriate amount of water for injection, filter and sterilize with a 0.22 μm filter membrane; under aseptic conditions, mix the above-mentioned transparent gel and filtrate evenly, and then package them.

Embodiment 2

[0043] prescription:

[0044]

[0045] The specific preparation method is:

[0046] Swell carbomer, hydroxypropyl methylcellulose and an appropriate amount of water for injection, adjust the pH value to form a transparent gel, then autoclave at 121 °C, and cool it for later use; grow recombinant bovine basic fibroblasts Factors and human serum albumin are dissolved in an appropriate amount of water for injection, and sterilized by filtration with a 0.22 μm filter membrane; the above-mentioned transparent gel and filtrate are mixed uniformly under aseptic conditions, and then packaged.

Embodiment 3

[0048] prescription:

[0049]

[0050] The specific preparation method is:

[0051] The hydroxypropyl methylcellulose was swollen with an appropriate amount of water for injection, and the pH value was adjusted to form a transparent gel, then autoclaved at 121°C, and cooled for later use; the recombinant bovine basic fibroblast growth factor and human blood were mixed. The albumin is dissolved in an appropriate amount of water for injection, and sterilized by filtration with a 0.22 μm filter membrane; the above-mentioned transparent gel and the filtrate are mixed uniformly under aseptic conditions, and then packaged.

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PUM

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Abstract

Provided are recombination cattle alkaline fibroblast growth factor gel and preparation method of the same. Components and dosage of the gel are as follows: 10000 to 30000 IU of recombination cattle alkaline fibroblast growth factors, 0.5 to 2.5 mg of protein protective agent, 10 to 30 mg of gel matrix, a right amount of pH regulators and 5ml of water for injection. The gel agent is simple in accessory, can reach good stability and releasing effect and is capable of treating various surfaces of wound caused by scalding and trauma.

Description

technical field [0001] The present invention relates to the field of biological products. In particular, it relates to a recombinant bovine basic fibroblast growth factor gel and a preparation method thereof. Background technique [0002] The skin is an important barrier to the body from infection and dehydration, and severe trauma, burns, and skin ulcers caused by certain diseases such as diabetes can have a huge physical and mental impact on patients. Therefore, the repair of skin wounds is an issue of great concern in the field of medicine. [0003] Since the end of the last century, a variety of studies have been carried out on the post-traumatic tissue repair process, mechanism and treatment. The level has been continuously improved. At present, a variety of genes that promote granulation tissue growth, vascularization and re-epithelialization have been constructed, such as epidermal cytokine, basic fibroblast growth factor and transforming growth factor. [0004] I...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/18A61K9/00A61K47/42A61P17/02
Inventor 陈咏郑赞顺姜若峰朱爱堂蓝瑄寻新平陈雄来
Owner ZHUHAI ESSEX BIO PHARMA
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