Composite coating having antibacterial performance and biocompatibility as well as preparation method and application of composite coating

A biocompatible and composite coating technology, which is applied in the field of composite coatings with both antibacterial and biocompatibility and its preparation, can solve the antibacterial effect of toxic and side effects, short service life of cells, limited application range, etc. problem, to achieve the effects of promoting cell proliferation and differentiation, reducing the decline in antibacterial performance, and simple process

Active Publication Date: 2018-11-30
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] In view of the deficiencies of the prior art and actual needs, the present invention provides a composite coating with both antibacterial and biocompatibility and its preparation method and application. The composite coating of the present invention can be prepared quickly, easily, and efficiently Antibacterial coating, and does not affect the normal proliferation of cells or increase cell adhesion and proliferation, overcome the high cost of preparation of traditional antibacterial materials, short service life and certain toxic side effects on cells and the poor antibacterial effect of traditionally used antibacterial agents. limited range of issues

Method used

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  • Composite coating having antibacterial performance and biocompatibility as well as preparation method and application of composite coating
  • Composite coating having antibacterial performance and biocompatibility as well as preparation method and application of composite coating
  • Composite coating having antibacterial performance and biocompatibility as well as preparation method and application of composite coating

Examples

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Comparison scheme
Effect test

Embodiment 1

[0066] A composite coating with both antibacterial and biocompatibility, the flow chart of its preparation method is as follows figure 1 As shown, the details are as follows:

[0067] (1) Use the polished titanium as the substrate, ultrasonically in deionized water, ethanol and acetone respectively for 30 minutes, and then use a nitrogen gun to clean the surface;

[0068] (2) Fix the cleaned titanium sheet on the evaporation plate, adopt the electron beam evaporation method, the vacuum degree is 670Pa, the coating rate is 0.16nm / min, TaCu 5 The alloy is used as a target material, and a 40nm TaCu layer is vapor-deposited on the titanium surface obtained in step (1);

[0069] (3) A 5nm Ta layer is vapor-deposited on the surface of the vapor-deposited layer in step (2), and the substrate surface obtains an antibacterial coating with good biocompatibility, and the anti-escherichia coli effect is shown in Figure 2A and Figure 2B .

Embodiment 2

[0071] A composite coating with both antibacterial and biocompatibility, the preparation method of which is as follows:

[0072] (1) The polished titanium alloy Ti-6Al-4V was used as the substrate, and the surface was ultrasonically cleaned in deionized water, ethanol, and acetone for 30 minutes, and then the surface was cleaned with a nitrogen gun;

[0073](2) Fix the cleaned titanium sheet on the evaporation plate, adopt the electron beam evaporation method, the vacuum degree is 465Pa, the coating rate is 0.2nm / min, TaCu 5 The alloy is used as a target material, and a 500nm TaCu layer is vapor-deposited on the titanium surface obtained in step (1);

[0074] (3) On the surface of the vapor-deposited layer in step (2), a 10nm Ta layer is vapor-deposited again, and the surface of the substrate obtains an antibacterial coating with good biocompatibility, and the anti-staphylococcus aureus effect is shown in Figure 3A and Figure 3B .

Embodiment 3

[0076] A composite coating with both antibacterial and biocompatibility, the preparation method of which is as follows:

[0077] (1) Use the polished titanium as the substrate, ultrasonically in deionized water, ethanol and acetone respectively for 30 minutes, and then use a nitrogen gun to clean the surface;

[0078] (2) Fix the cleaned titanium sheet on the evaporation plate, adopt electron beam evaporation method, TaCu 5 The alloy is used as the target material, the vacuum degree is 940Pa, and the coating rate is 0.12nm / min, and a 100nm TaCu layer is vapor-deposited on the titanium surface obtained in step (1);

[0079] (3) Evaporate a 40nm Ta layer on the surface of the vapor-deposited layer in step (2), and the substrate surface obtains an antibacterial coating with good biocompatibility, and the anti-staphylococcus aureus effect is shown in Figure 4A and Figure 4B .

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Abstract

The invention provides a composite coating having antibacterial performance and biocompatibility. The composite coating includes an antibacterial coating and a biocompatibility coating, wherein the antibacterial coating is 2-1000nm thick; and the biocompatibility coating is 2-500nm thick. With the application of a mode of combining the antibacterial coating and the biocompatibility coating, the service life of the coating (the composite coating) is prolonged; the composite coating, which is simple in process, can be continuously and rapidly prepared by a large area; a better antibacterial effect can be achieved, so that antibacterial elements can be released at moderate speed; the biocompatibility coating, under the conditions, can avoid influence to release of antibacterial elements and development of antibacterial performance; and therefore, the composite coating is an ideal coating of implantable medical apparatuses.

Description

technical field [0001] The invention belongs to the field of medical equipment, and relates to a composite coating with antibacterial and biocompatibility, a preparation method and application thereof. Background technique [0002] An implantable medical device is a device that achieves the following purposes through surgical means: it is inserted in whole or in part into the human body or cavity (mouth); it is used to replace the upper epidermis or the surface of the eye, and it remains in the body for at least 30 days, and it can only be passed through Surgical or medical means to remove. Such as: bone nails, bone plates, artificial organs, heart stents, artificial joints, cardiac pacemakers, etc. [0003] The implanted device must be sterile, and it is also carried out in a sterile environment during the packaging and implantation process. Although disinfectants or antibacterial agents will be used directly before the surgical incision is closed during the implantation p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/02A61L27/06A61L27/54A61L31/16A61L27/30A61L31/08C23C4/06C23C4/10C23C14/16C23C14/30C23C28/00C23C28/02
CPCA61L27/06A61L27/306A61L27/54A61L31/022A61L31/088A61L31/16C23C4/06C23C4/10C23C14/16C23C14/30C23C28/023C23C28/322C23C28/345A61L2300/102A61L2300/404A61L2420/04A61L2300/604
Inventor 任富增李玉磊张锐王尧
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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