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Closed hydrogel as well as preparation method and application thereof

A technology of sealing water and gel, which is applied in medical science, surgery, etc., can solve the problems of high swelling rate of sealed hydrogel, low swelling rate of hydrogel, and bad tissue stimulation, so as to achieve good drug release performance and reduce damage to Effects on the human body, swelling rate reduction effect

Active Publication Date: 2020-11-10
NKD PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the risk of nerve compression in spinal wounds, dura mater or dura mater sealing hydrogel in clinical use, the swelling rate of the hydrogel is required to be as low as possible; in addition, for patients with other treatment needs such as inflammation, not only The wound needs to be sealed and drug-loaded for treatment; in addition, the low-swelling PEG hydrogel used in the current technology is relatively strong in acidity and alkalinity, and there are adverse stimulations to the tissue during use; the sealing hydrogel currently on the market swells The rate is high, the drug cannot be loaded or the sealing performance will be affected after the drug is loaded

Method used

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  • Closed hydrogel as well as preparation method and application thereof
  • Closed hydrogel as well as preparation method and application thereof
  • Closed hydrogel as well as preparation method and application thereof

Examples

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preparation example Construction

[0100] The present invention also protects the preparation method of the hydrogel of the present invention, comprising the following steps:

[0101] 1) Mixing the first component and the second component with buffer a to obtain a mixed liquid system;

[0102] 2) Mix buffer b with the mixed solution system to obtain a blocked hydrogel.

[0103] The present invention also protects a kit for preparing the sealed hydrogel of the present invention, the kit is provided with a double syringe, and the first component and the second component are dissolved in buffer a and stored in the syringe 1 in; the buffer b is stored in syringe 2.

[0104]According to some preferred embodiments, during the use of the kit described in the present invention, the drug can be added to solution a or solution b, for acidic or neutral drugs added to solution a, for drugs that are stable under alkaline conditions Add to solution b.

[0105] The present invention also protects the application of the sea...

experiment example 1

[0123] The loading amount of methylprednisolone in Experimental Example 1 is the dosage of a commercially available single bottle. In Experimental Example 2, the loading amount of methylprednisolone was increased by 3 times. After the test results, there is no obvious decrease after increasing the loading amount in terms of swelling rate and sealing strength. Experimental Example 4 is the effect of loading a commercially available Diprosone injection. From the results, the performance of the gel itself is not significantly affected after being loaded with Diprosone, and the drug release cycle of the sealed hydrogel described in the present invention short.

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Abstract

The invention belongs to the technical field of high polymer materials, and particularly relates to closed hydrogel as well as a preparation method and application thereof. Raw materials for preparingthe closed hydrogel comprise a first component and a second component, wherein the first component comprises a compound A and a compound B; the compound A is a derivative of multi-arm polyethylene glycol, and the compound B is multi-arm copolyester of glycidyl isopropyl ether and ethyl glycidyl ether; and the second component comprises oligopeptide or a derivative thereof. According to the hydrogel, the swelling rate of the hydrogel can be effectively reduced by selecting high molecular weight compounds in the gel components and matching the first component with the second component.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a closed hydrogel and a preparation method thereof. Background technique [0002] The hydrogel products developed based on PEG derivatives have good biocompatibility, non-toxicity, non-irritation, and biodegradability. In clinical application, there is no need to remove them after surgery. The products will gradually degrade and pass through the kidneys as the patient recovers. Metabolism and other advantages, there are a variety of PEG-based hydrogel sealants on the market, which are used for wound sealing, anti-adhesion, and leakage sealing. In recent years, with the increase in spinal revision surgery, severe dural adhesions and elderly patients, the incidence of CSFL also tends to increase. Proper treatment of cerebrospinal fluid leakage is of great significance to the success of spinal surgery and the prevention of serious complications. Due to the ri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/04A61L31/14A61L31/16C08J3/075C08L71/02C08L67/00C08L5/08
CPCA61L31/06A61L31/047A61L31/042A61L31/145A61L31/14A61L31/16C08J3/075A61L2300/404A61L2300/236A61L2300/602C08J2371/02C08J2467/00C08J2367/00C08J2471/02C08J2405/08C08L71/02C08L67/00C08L89/00C08L5/08A61L24/0031A61L24/0042A61L24/0015A61L24/046A61L2300/402A61L2300/41A61L2300/418A61L2300/416C08J2377/04C08J2477/04C08L77/04
Inventor 冷鸿飞徐小雨陶秀梅
Owner NKD PHARMA CO LTD
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