52results about How to "Excellent drug release performance" patented technology

The present invention provides water soluble chitosan microspheres which can be used for loading drug and a preparation method thereof. The structure of the microsphere is that the outside of crosslinking state water soluble chitosan core which can load the drug is orderly enwrapped with a crosslinking state water soluble chitosan coating layer and a crosslinking solidified outer surface layer, which can be used for loading and controlling releasing the drug. The preparation method is that the drug which is mixed with the water soluble chitosan and corresponding water dispersion and oil component are used to form W/O type mixture which is reacted with twain-aldehyde crosslinking agent to obtain microsphere core; water soluble chitosan solution is used to form crosslinking state coating layar at the outer side of the microsphere core; finally, the crosslinking solidified outer surface layer is formed through the second crosslinking reaction. The chitosan microsphere for loading the drug has controllable particle size distribution and slow-release effect, obviously improved intensity and good biological compatibility and biological adhesion, which enlarges the application range for loading drug and has good effect of drug loading, controlling and releasing; the chitosan microsphere for loading the drug can be applied to a plurality of medication forms, such as hypodermic, intravenous and intraperitoneal injection medications, orally taking, etc., the preparation method is simple and feasible with mild condition and low production cost.

The invention provides a drug delivery balloon dilating catheter of a double-layer balloon structure. The drug delivery balloon dilating catheter comprises a pressurizing hole-free inner balloon body and an outer balloon body with a drug-permeable micro-hole permeable membrane. Compared with the prior art, the hole diameter of the drug delivery balloon dilating catheter is even, and the high porosity and the high mechanical strength are achieved. The invention further discloses a manufacturing method of the drug delivery balloon dilating catheter of the double-layer balloon structure, the drug delivery balloon dilating catheter is made of materials such as polyethylene or nylon 12, the micro-hole permeable membrane is manufactured with a thermally induced phase separation method, and the drug delivery balloon dilating catheter has the advantages of being simple in manufacturing process, suitable for large-scale production, low in manufacturing cost and the like.

This invention uses mesoporous silica nanoparticles and other nanostructured materials to formulate polyacrylate-based bone cement for achieving an enhanced and controlled elution of active ingredients such as antibiotics. This invention overcomes the limitation of low antibiotic release from commercial polyacrylate-based bone cements using for example, PMMA. In certain aspects, the formulation enables a sustained release of antibiotics from the bone cement over a period of 80 days and achieves 70% of total drug release, whereas the commercial antibiotic bone cement (e.g., SmartSet GHV) only releases about 5% of the antibiotics on the first day and subsequently an almost negligible amount. In addition, the mechanical properties of our formulated bone cements are well retained. The inventive bone cement exhibits good antibacterial properties and has very low cytotoxicity to mouse fibroblast cells.

The invention discloses hollow hierarchical hydroxyapatite microspheres and a preparation method and application thereof. The preparation method comprises the following steps of: (1) dissolving diammonium hydrogen phosphate into deionized water, adjusting the pH value of the solution to be 5.8 to 6.0 by using nitric acid, adding calcium nitrate so that the molar ratio of Ca<2+> to PO4<3-> in the solution is 1.6 to 1.7, continuously adjusting the pH value of the solution to be 5.0 by using the nitric acid, adding sodium citrate into the mixed solution to ensure that the concentration of the mixed solution is 9 to 20 milligrams per milliliter, and continuously stirring; and (2) transferring the mixed solution of the step (1) to a high pressure reactor, wherein the volume of the mixed solution accounts for 50 to 80 percent of the total volume of the reactor; and reacting for 1 to 12 hours at the temperature of between 80 and 220 DEG C, performing natural cooling, washing for 3 to 5 times, and drying to obtain the hollow hierarchical hydroxyapatite microspheres. The preparation method for the microspheres is simple and low in time consumption; and the microspheres have excellent medicament release property, are suitable for industrial production, and have a good application prospect.

The invention relates to a method for manufacturing a low-polylactic acid-beta-cyclodextrin and polylactic acid blended nano-fiber. The method includes dissolving low-polylactic acid-beta-cyclodextrin and polylactic acid in methylene chloride and N,N-dimethylformamide (DMF), stirring the mixture until the low-polylactic acid-beta-cyclodextrin and the polylactic acid are completely dissolved, and performing standing ultrasonic treatment for the solution to obtain transparent low-polylactic acid-beta-cyclodextrin and polylactic acid solution; and adding the low-polylactic acid-beta-cyclodextrin and polylactic acid blended solution in an injection pump, adjusting electrospinning voltage to range from 15kV to 28kV, setting the distance from a spinning nozzle to a collecting plate to range from 15cm to 25cm and solution flow rate to range from 1.0mL/h to 2.0mL/h, using a collector as an aluminum foil and carrying out high-voltage electrospinning to obtain the low-polylactic acid-beta-cyclodextrin and polylactic acid blended nano-fiber. The prepared functional nano-fiber has excellent biocompatibility and biodegradability and accordingly has a high application value in drug controlled release systems.

The invention provides a preparation method of a PVP-modified sodium alginate/polydopamine composite nano-material. The preparation method is characterized by comprising the following steps: sprayingan aqueous solution containing sodium alginate and dopamine to a coagulating bath with pH 9-11 and containing polyvinylpyrrolidone (PVP), CaCl2 and trihydroxymethyl aminomethane, centrifuging and separating, and washing to obtain the PVP-modified sodium alginate/polydopamine composite nano-material. In vitro/in vivo biosecurity experiments and cancer therapy experiments prove that the PVP-modifiedsodium alginate/polydopamine composite nano-material has excellent biocompatibility, phototherapeutic ability and photothermal therapy and chemotherapy combined treatment ability.

The invention belongs to the technical field of high polymer materials, and particularly relates to closed hydrogel as well as a preparation method and application thereof. Raw materials for preparingthe closed hydrogel comprise a first component and a second component, wherein the first component comprises a compound A and a compound B; the compound A is a derivative of multi-arm polyethylene glycol, and the compound B is multi-arm copolyester of glycidyl isopropyl ether and ethyl glycidyl ether; and the second component comprises oligopeptide or a derivative thereof. According to the hydrogel, the swelling rate of the hydrogel can be effectively reduced by selecting high molecular weight compounds in the gel components and matching the first component with the second component.

The invention provides a preparation method of a reducibly degradable amphiphilic block copolymer used as a drug carrier, and belongs to the technical field of macromolecular chemical and biological medicines. The method comprises a step of bonding rhodamine B serving as a fluorescent agent to a disulfide bond monomer through esterification, and bonding to N-(2-hydroxypropyl) methacrylamide in a RAFT mode to form the amphiphilic block copolymer with high biocompatibility. According to the amphiphilic block copolymer, a nano-micelle drug carrier can be formed in a mixed solution of methanol and water. In a reducing environment, the disulfide bond in a hydrophobic chain segment of the amphiphilic block copolymer can be reduced into a sulfydryl group, and the grafted rhodamine B group is removed out of the side chain of the polymer to result in reduction of the grain size of micelle and obvious change of the structural properties of the drug carrier, so that the amphiphilic block copolymer shows high reducibility, degradability and drug release property; therefore, the amphiphilic block copolymer can be used as the drug carrier to be applied to preparation of medicines.

The invention provides a surface coating composition of an implantable medical apparatus, the medical apparatus and a manufacturing method of the medical apparatus, wherein the surface coating composition is at least prepared by mixing a degradable carrier and therapeutic drugs; the degradable carrier is selected from either polylactic acid or a copolymer thereof; and the weight of the therapeutic drugs accounts for 0.1-80% in terms of the weight of the surface coating. The coating provided by the invention has such outstanding performances that the coating is excellent in drug controlled-release property, good in binding property with a main body stent, uniform in degradation and the like, and a degradation product is harmless to human body. Meanwhile, a provided coating preparation technique has significant advantages of being simple and convenient to operate, high in yield, being controllable and the like.

The invention discloses drug controlled-release mesoporous silicon nanoparticles and a preparation method thereof. The preparation method comprises the following steps: (1) adding 3-aminopropyltriethoxysilane into mesoporous silicon nanoparticles, carrying out a reflux reaction under the protection of nitrogen by taking toluene as a solvent, washing with ultrapure water and ethanol after the reaction is finished, and carrying out vacuum drying to obtain aminated mesoporous silicon nanoparticles MSN-NH2; (2) dissolving the aminated mesoporous silicon nanoparticles in acetonitrile, adding 1-pyreneformaldehyde for a reaction, centrifuging after the reaction is finished, washing with ultrapure water and ethanol, and performing vacuum drying to obtain MSN-N = CH-Py; and (3) taking MSN-N = CH-Py, adding a to-be-loaded drug solution to react, adding beta-cyclodextrin to continue to react after the reaction is finished, centrifuging after the reaction is finished, washing with ultrapure waterand ethanol, and carrying out vacuum drying to obtain the product. The drug controlled-release mesoporous silicon nanoparticles disclosed by the invention have good responsiveness to pH, and have gooddrug loading capacity and drug controlled-release performance.

A medical cold compress patch includes a backing layer, a gel layer and a covering layer. The gel layer includes various raw materials, and each raw material is measured as following mass percentage, 2 to 15 mass percent of macromolecule substance, 2 to 10 mass percent of epidermal growth factor, 2 to 8 mass percent of ceramide, 3 to 8 mass percent of humectant, 3 to 10 mass percent of bupleurum sinensis extract, 2 to 8 mass percent of dandelion extract, 3 to 12 mass percent of cortex phellodendri extract, 5 to 10 mass percent of aloe vera extract, 2 to 10 mass percent of honeysuckle flowers extract and the balance being purified water. A method for preparing medical cold compress patch is also disclosed.

The invention discloses a preparation method and application of graphene oxide modified carboxymethyl chitosan composite hydrogel, an ionic cross-linking method is adopted, a graphene oxide dispersion solution is added into a carboxymethyl chitosan solution according to a proportion, uniform mixing is performed, triphosphoric acid is added, gelatin is added to enhance water solubility and biocompatibility, and the graphene oxide modified carboxymethyl chitosan composite hydrogel is prepared. According to the present invention, the prepared composite hydrogel material has characteristics of large specific surface area, good swelling property, good thermal stability, good biocompatibility and good pH sensitive property, can be used as the sustained-release material, can improve the adhesion site of the drug, can improve the drug loading capacity, has good drug controlled-release performance, and can be used in the field of drug delivery. The medicine release time can be prolonged, the medicine curative effect is improved, the administration frequency is reduced, the precise controlled release efficiency of the medicine is improved, and the in-vitro release of the medicine is favorably controlled.

The invention relates to the technical field of drug carriers, in particular to a magnetic nano-drug carrier as well as a preparation method and an application thereof. The magnetic nano-drug carrier comprises an SP94 targeting peptide and a coupling product of an siRNA delivery carrier, and the coupling product of the siRNA delivery carrier comprises superparamagnetic iron oxide nanoparticles and quaternary ammonium cationized amylose-tetraphenylethylene-superparamagnetic iron oxide nanoparticles formed by coupling quaternary ammonium cationized amylose and tetraphenylethylene, and the siRNA is adsorbed in the magnetic nano-drug carrier. The cytotoxicity experiments prove that the nano-drug carrier has good biocompatibility, good stability, targeting property and drug release property, and the magnetic nano-drug carrier can be applied to preparation of cancer gene therapy drugs.

The invention discloses a soluble self-healing natural polymer hydrogel and a preparation method thereof. Natural polymer sodium alginate can be used as raw material, functional monomer methacrylic acid can be introduced, initiator and deionized water can be used as auxiliary raw material, and thus the natural polymer hydrogel (SAM) with excellent self-healing and solubility can be prepared by one-pot method. The hydrogel prepared by the invention has the advantages of fast self-healing rate, healing with no limitation of incision section and good solubility. The hydrogel is put into a certainamount of water, and the hydrogel can be completely dissolved without residue. The hydrogel is used as a drug carrier, and the drug release rate is stable, and the 100% of drug can be completely released without residue. And the prepared hydrogel has good biocompatibility and degradability, and the soluble self-healing natural polymer hydrogel prepared by the invention has wide application prospects in the fields of biomedical materials such as wound dressing, tissue organ culture and biological scaffold materials.