Preparation method and application of graphene oxide modified carboxymethyl chitosan composite hydrogel

A technology of carboxymethyl chitosan and composite hydrogel, which can be applied to medical preparations with non-active ingredients, non-active ingredients of polymer compounds, and medical preparations containing active ingredients, etc. and other problems, to achieve the effect of large specific surface area, increase swelling, and reduce the number of doses

Pending Publication Date: 2022-03-11
广东省科学院生物与医学工程研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the crosslinking method needs to add 4,4′-dimethyltriphenylmethane-2,2′,5,5′-tetraisocyanate crosslinking agent, which is harmful to the human body and pollutes the environment

Method used

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  • Preparation method and application of graphene oxide modified carboxymethyl chitosan composite hydrogel
  • Preparation method and application of graphene oxide modified carboxymethyl chitosan composite hydrogel
  • Preparation method and application of graphene oxide modified carboxymethyl chitosan composite hydrogel

Examples

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Effect test

Embodiment 1

[0032] Example 1: Preparation method and application of a graphene oxide-modified carboxymethyl chitosan composite hydrogel

[0033] Include the following steps:

[0034] (1), dissolve carboxymethyl chitosan in deionized water, and continue magnetic stirring until completely dissolved to obtain a certain mass of carboxymethyl chitosan solution, carboxymethyl chitosan in carboxymethyl chitosan solution The mass concentration is 0.5wt%;

[0035] (2), adding graphene oxide into deionized water, ultrasonic 30min, obtains dispersed graphene oxide solution, the mass concentration of graphene oxide in the graphene oxide solution is 0.5mg / mL;

[0036] (3), get 90 milliliters of carboxymethyl chitosan solution and 10 milliliters of graphene oxide solutions and beaker, and add 1 mL of triphosphoric acid solution, continue magnetic stirring 2h, obtain carboxymethyl chitosan graphene oxide composite solution;

[0037] (4), weigh 0.8g of gelatin and add it into the carboxymethyl chitosan...

Embodiment 2

[0051] Example 2: Preparation method and application of a graphene oxide-modified carboxymethyl chitosan composite hydrogel

[0052] Include the following steps:

[0053] (1), dissolve carboxymethyl chitosan in deionized water, and continue magnetic stirring until completely dissolved to obtain a certain mass of carboxymethyl chitosan solution, carboxymethyl chitosan in carboxymethyl chitosan solution The mass concentration is 5wt%;

[0054] (2), graphene oxide was added into deionized water, ultrasonically dispersed for 30 minutes to obtain a dispersed graphene oxide solution, and the mass concentration of graphene oxide in the graphene oxide solution was 1.5 mg / mL;

[0055] (3), get 70 milliliters of carboxymethyl chitosan solution and 30 milliliters of graphene oxide solutions and beaker, and add triphosphoric acid solution 1mL, continue magnetic stirring 2h, obtain carboxymethyl chitosan graphene oxide composite solution;

[0056] (4) Weigh 1.5g of gelatin and add it to ...

Embodiment 3

[0059] Example 3: Preparation method and application of a graphene oxide-modified carboxymethyl chitosan composite hydrogel

[0060] Include the following steps:

[0061] (1), carboxymethyl chitosan is dissolved in deionized water, continuous magnetic stirring is until fully dissolved, and a certain quality carboxymethyl chitosan solution is obtained; carboxymethyl chitosan in carboxymethyl chitosan solution The mass concentration is 10wt%.

[0062] (2), graphene oxide is added into deionized water, ultrasonic 30min to complete dispersion, obtain graphene oxide solution, the mass concentration of graphene oxide in the graphene oxide solution is 2mg / mL;

[0063] (3), get 50 milliliters of carboxymethyl chitosan solution and 50 milliliters of graphene oxide solutions and beaker, and add triphosphoric acid solution 1mL, continue magnetic stirring 2h, obtain carboxymethyl chitosan graphene oxide composite solution;

[0064] (4) Weigh 2.0 g of gelatin and add it to the carboxymet...

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Abstract

The invention discloses a preparation method and application of graphene oxide modified carboxymethyl chitosan composite hydrogel, an ionic cross-linking method is adopted, a graphene oxide dispersion solution is added into a carboxymethyl chitosan solution according to a proportion, uniform mixing is performed, triphosphoric acid is added, gelatin is added to enhance water solubility and biocompatibility, and the graphene oxide modified carboxymethyl chitosan composite hydrogel is prepared. According to the present invention, the prepared composite hydrogel material has characteristics of large specific surface area, good swelling property, good thermal stability, good biocompatibility and good pH sensitive property, can be used as the sustained-release material, can improve the adhesion site of the drug, can improve the drug loading capacity, has good drug controlled-release performance, and can be used in the field of drug delivery. The medicine release time can be prolonged, the medicine curative effect is improved, the administration frequency is reduced, the precise controlled release efficiency of the medicine is improved, and the in-vitro release of the medicine is favorably controlled.

Description

Technical field: [0001] The invention relates to the technical field of functional materials, in particular to a preparation method and application of graphene oxide-modified carboxymethyl chitosan composite hydrogel. Background technique: [0002] Carboxymethyl chitosan hydrogel is a soft biomaterial due to its 3D porous network structure, nontoxicity, high water content, swelling / deswelling properties, flexibility, good biocompatibility and adaptive biodegradation have been extensively studied in the fields of tissue engineering and drug delivery. [0003] However, carboxymethyl chitosan hydrogel alone has poor mechanical properties and stability, and will disintegrate rapidly, easily leading to drug burst release during drug delivery. Therefore, in order to improve the mechanical properties and multifunctionality of carboxymethyl chitosan hydrogels, mineral nanoparticles (such as clay, graphene oxide, hydroxyapatite) are usually introduced into the hydrogel structure to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L5/08C08L89/00C08K3/04C08K3/32A61K47/36A61K47/04A61K47/42A61K9/06A61K31/192A61K31/616A61K38/38
CPCC08J3/075A61K47/36A61K47/02A61K47/42A61K9/06A61K31/192A61K31/616A61K38/385C08J2305/08C08J2489/00C08K3/042C08K2003/329
Inventor 李辰谢东李发勇王珂王青刘海露孙晓燕
Owner 广东省科学院生物与医学工程研究所
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