Hollow hierarchical hydroxyapatite microspheres and preparation method and application thereof
A technology of structural hydroxyapatite and microspheres, which is applied in chemical instruments and methods, medical preparations of non-active ingredients, and devices that make drugs into special physical or ingestible forms, and can solve the problem of reducing the use value of materials, The preparation process takes a long time and is unfavorable for industrial production, and achieves the effects of large-scale industrial production, excellent drug release performance, and time and process cost savings.
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[0026] 1. Preparation of hollow hierarchical microspheres:
[0027] First, dissolve 0.473g of diammonium hydrogen phosphate in 300ml of deionized water, adjust the pH of the solution to 6.0, then add 1.41g of calcium nitrate tetrahydrate, and stir for 2 minutes. After the calcium nitrate tetrahydrate is completely dissolved, continue to use 2mol / L nitric acid to adjust the solution After the pH reaches 5, weigh 4.5g of calcium citrate hexahydrate and add it to the above mixture, and stir for 10min at a stirring speed of 200rpm. The solution was transferred to a 100ml polytetrafluoroethylene-lined autoclave, the volume of the mixed liquid accounted for 60% of the total volume of the autoclave, and reacted in an oven at 180°C for 2 hours. Cool naturally, wash with water for 3-5 times, and freeze-dry to obtain hydroxyapatite microspheres with hollow hierarchical structure.
[0028] figure 1 The microspheres have an obvious hollow structure, and the XRD pattern shows that the di...
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