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Hollow hierarchical hydroxyapatite microspheres and preparation method and application thereof

A technology of structural hydroxyapatite and microspheres, which is applied in chemical instruments and methods, medical preparations of non-active ingredients, and devices that make drugs into special physical or ingestible forms, and can solve the problem of reducing the use value of materials, The preparation process takes a long time and is unfavorable for industrial production, and achieves the effects of large-scale industrial production, excellent drug release performance, and time and process cost savings.

Active Publication Date: 2013-04-24
广州康睿医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Generally, in the process of synthesizing hierarchical structure powder, it is inevitable to use some surfactants, template agents and toxic chemical reagents. In order to reduce the toxicity of materials and improve the performance of materials, these surfactants need to be removed, and these The cumbersome cleaning process is not conducive to large-scale industrial production on the one hand; on the other hand, the structure of the material will be damaged, thereby reducing the use value of the material
At the same time, the preparation process takes a long time, generally more than 12 hours

Method used

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  • Hollow hierarchical hydroxyapatite microspheres and preparation method and application thereof
  • Hollow hierarchical hydroxyapatite microspheres and preparation method and application thereof
  • Hollow hierarchical hydroxyapatite microspheres and preparation method and application thereof

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Embodiment 1

[0026] 1. Preparation of hollow hierarchical microspheres:

[0027] First, dissolve 0.473g of diammonium hydrogen phosphate in 300ml of deionized water, adjust the pH of the solution to 6.0, then add 1.41g of calcium nitrate tetrahydrate, and stir for 2 minutes. After the calcium nitrate tetrahydrate is completely dissolved, continue to use 2mol / L nitric acid to adjust the solution After the pH reaches 5, weigh 4.5g of calcium citrate hexahydrate and add it to the above mixture, and stir for 10min at a stirring speed of 200rpm. The solution was transferred to a 100ml polytetrafluoroethylene-lined autoclave, the volume of the mixed liquid accounted for 60% of the total volume of the autoclave, and reacted in an oven at 180°C for 2 hours. Cool naturally, wash with water for 3-5 times, and freeze-dry to obtain hydroxyapatite microspheres with hollow hierarchical structure.

[0028] figure 1 The microspheres have an obvious hollow structure, and the XRD pattern shows that the di...

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Abstract

The invention discloses hollow hierarchical hydroxyapatite microspheres and a preparation method and application thereof. The preparation method comprises the following steps of: (1) dissolving diammonium hydrogen phosphate into deionized water, adjusting the pH value of the solution to be 5.8 to 6.0 by using nitric acid, adding calcium nitrate so that the molar ratio of Ca<2+> to PO4<3-> in the solution is 1.6 to 1.7, continuously adjusting the pH value of the solution to be 5.0 by using the nitric acid, adding sodium citrate into the mixed solution to ensure that the concentration of the mixed solution is 9 to 20 milligrams per milliliter, and continuously stirring; and (2) transferring the mixed solution of the step (1) to a high pressure reactor, wherein the volume of the mixed solution accounts for 50 to 80 percent of the total volume of the reactor; and reacting for 1 to 12 hours at the temperature of between 80 and 220 DEG C, performing natural cooling, washing for 3 to 5 times, and drying to obtain the hollow hierarchical hydroxyapatite microspheres. The preparation method for the microspheres is simple and low in time consumption; and the microspheres have excellent medicament release property, are suitable for industrial production, and have a good application prospect.

Description

technical field [0001] The invention relates to a method for preparing hydroxyapatite microspheres with a hollow hierarchical structure. In addition to good biocompatibility, the prepared powder has high-efficiency drug loading and excellent drug release performance, making it a very promising drug carrier material. Background technique [0002] Synthetic hydroxyapatite has good biocompatibility, bioactivity, osteoconduction and even osteoinduction properties due to its chemical composition similar to natural apatite, and has been widely used in biomedical fields, such as drugs or gene carriers . In addition to good biocompatibility, these carriers also need to have a large specific surface area, so a lot of research has been devoted to the synthesis process of hierarchical structure powders, in which three-dimensional hollow hierarchical structure particles are used as a branch, so It has attracted extensive attention due to its permeable shell and high specific surface a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32A61J3/02A61K47/04A61K38/14A61K9/19
Inventor 王迎军杨辉杜昶赵娜如
Owner 广州康睿医疗器械有限公司
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