Hollow hierarchical hydroxyapatite microspheres and preparation method and application thereof

Abstract

The invention discloses hollow hierarchical hydroxyapatite microspheres and a preparation method and application thereof. The preparation method comprises the following steps of: (1) dissolving diammonium hydrogen phosphate into deionized water, adjusting the pH value of the solution to be 5.8 to 6.0 by using nitric acid, adding calcium nitrate so that the molar ratio of Ca<2+> to PO4<3-> in the solution is 1.6 to 1.7, continuously adjusting the pH value of the solution to be 5.0 by using the nitric acid, adding sodium citrate into the mixed solution to ensure that the concentration of the mixed solution is 9 to 20 milligrams per milliliter, and continuously stirring; and (2) transferring the mixed solution of the step (1) to a high pressure reactor, wherein the volume of the mixed solution accounts for 50 to 80 percent of the total volume of the reactor; and reacting for 1 to 12 hours at the temperature of between 80 and 220 DEG C, performing natural cooling, washing for 3 to 5 times, and drying to obtain the hollow hierarchical hydroxyapatite microspheres. The preparation method for the microspheres is simple and low in time consumption; and the microspheres have excellent medicament release property, are suitable for industrial production, and have a good application prospect.

Description

technical field [0001] The invention relates to a method for preparing hydroxyapatite microspheres with a hollow hierarchical structure. In addition to good biocompatibility, the prepared powder has high-efficiency drug loading and excellent drug release performance, making it a very promising drug carrier material. Background technique [0002] Synthetic hydroxyapatite has good biocompatibility, bioactivity, osteoconduction and even osteoinduction properties due to its chemical composition similar to natural apatite, and has been widely used in biomedical fields, such as drugs or gene carriers . In addition to good biocompatibility, these carriers also need to have a large specific surface area, so a lot of research has been devoted to the synthesis process of hierarchical structure powders, in which three-dimensional hollow hierarchical structure particles are used as a branch, so It has attracted extensive attention due to its permeable shell and high specific surface a...

AI Technical Summary

Problems solved by technology

[0003] Generally, in the process of synthesizing hierarchical structure powder, it is inevitable to use some surfactants, template agents and toxic chemical reagents. In order to reduce the toxicity of materials and improve the performance of materials, these surfactants need to be removed, and these The cumbersome cleaning process is not conducive to large-scale industrial production on the one hand; on the other hand, the structure of the material will be damaged, thereby reducing the use value of the material

At the same time, the preparation process takes a long time, generally more than 12 hours

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