Surface coating composition of implantable medical apparatus, medical apparatus and manufacturing method of medical apparatus

A technology for implanting medical devices and surface coatings, applied in the field of medical devices, can solve the problems of unsuitable degradable vascular stents, etc., and achieve the effects of excellent drug controlled release performance, controllable process, and easy operation

Inactive Publication Date: 2017-02-15
NANJING YONGMING MEDICAL APP & INSTR CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The above-mentioned coating modification materials are mainly aimed at metal stents, and the modified coating uses polysulfone-polyoxyethylene block copolymer, which is not suitable for degradable vascular stents

Method used

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  • Surface coating composition of implantable medical apparatus, medical apparatus and manufacturing method of medical apparatus
  • Surface coating composition of implantable medical apparatus, medical apparatus and manufacturing method of medical apparatus
  • Surface coating composition of implantable medical apparatus, medical apparatus and manufacturing method of medical apparatus

Examples

Experimental program
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Embodiment 1

[0068] Such as figure 1 As shown, the drug-loaded coating 2 is located on the outer surface of the degradable stent skeleton 1 (i.e. the outer surface of the cylindrical stent), and the drug-loaded coating 2 is a mixture composed of therapeutic drugs and degradable carriers, so The above-mentioned therapeutic drugs can be antithrombotic drugs: heparin, hirudin, prostacyclin, abciximab, etc.; anti-inflammatory drugs: dexamethasone (DXM), methylprednisolone, bisphosphonate liposomes, etc. ; Anti-VSMC proliferation drugs: rapamycin (RAPM), paclitaxel, angiopep, mycophenolic acid, tacrolimus, everolimus, cyclosporine A, methyl-RAPM, etc.; anti-VSMC migration drugs: Batimastat, etc.; drugs for promoting endothelial healing: 17β estradiol, vascular endothelial growth factor, etc.; other drugs: one or more of tetratoxazine and its combination with traditional Chinese medicines astragalus, ginseng, emodin, etc. The degradable carrier can be one of polylactic acid (PLLA and PDLLA) and...

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PUM

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Abstract

The invention provides a surface coating composition of an implantable medical apparatus, the medical apparatus and a manufacturing method of the medical apparatus, wherein the surface coating composition is at least prepared by mixing a degradable carrier and therapeutic drugs; the degradable carrier is selected from either polylactic acid or a copolymer thereof; and the weight of the therapeutic drugs accounts for 0.1-80% in terms of the weight of the surface coating. The coating provided by the invention has such outstanding performances that the coating is excellent in drug controlled-release property, good in binding property with a main body stent, uniform in degradation and the like, and a degradation product is harmless to human body. Meanwhile, a provided coating preparation technique has significant advantages of being simple and convenient to operate, high in yield, being controllable and the like.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to an implantable medical device surface coating composition, a medical device and its preparation. Background technique [0002] Angioplasty (Percutaneous Transluminal Coronary Angioplasty, PTCA) refers to a minimally invasive interventional operation that maintains unobstructed blood flow in blood vessels by inserting stents into diseased blood vessel segments to propel narrowed and occluded blood vessels. Due to the advantages of less risk, less trauma, faster postoperative recovery, simple operation and relatively low cost, the operation is widely used in the treatment of cardiovascular diseases, especially myocardial infarction caused by coronary artery stenosis. Specifically, according to its function, it can be subdivided into categories such as coronary stents, cerebrovascular stents, renal artery stents, and aortic stents. Currently, the stents on the market are made of metal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/14A61L31/16
CPCA61L31/10A61L31/148A61L31/16A61L2300/602A61L2300/606C08L67/04
Inventor 倪中华赵古田项楠冯滢滢许天楚王健
Owner NANJING YONGMING MEDICAL APP & INSTR CO LTD
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