Graphene oxide-hydrogel composite drug carrier

A graphene composite and hydrogel technology, which is applied in the loading and release of drugs in composite hydrogels, and the composite field of graphene materials and hydrogel materials, can solve the problems of loss of performance and easy agglomeration, and achieve good results. The effect of biocompatibility, good biocompatibility, great social benefit and economic benefit

Active Publication Date: 2013-09-04
西安萱御紫金药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nevertheless, graphene oxide is still easy to agglomerate in salt solution and monomer small molecule solution, so that it loses its unique and excellent properties.

Method used

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  • Graphene oxide-hydrogel composite drug carrier
  • Graphene oxide-hydrogel composite drug carrier
  • Graphene oxide-hydrogel composite drug carrier

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0049] Preparation of water-soluble graphene oxide:

[0050] Pre-oxidation process: weigh 0.5gK 2 S 2 o 8 , 0.5gP 2 o 5 , were slowly added to 30mL of concentrated sulfuric acid in turn, and then 1g of natural graphite powder was added to form a mixture solution, stirred and reacted at 80°C for 6h, and cooled to room temperature. Finally, it was washed and centrifuged with deionized water until pH = 7, and dried overnight in an oven at 60°C to obtain the preoxidized product.

[0051] Secondary oxidation process: Measure 23mL of concentrated sulfuric acid in a beaker, place it in an ice-water mixing bath, gradually add pre-oxidized graphite under constant stirring, control the reaction temperature below 10°C, and then slowly add 3gKMnO 4 , stir for a few minutes until the temperature no longer rises. The temperature was raised to 35°C and stirring was continued for 2 h, and 46 mL of deionized water was added. After continuing stirring for 15 min in a water bath at 98°C, ...

Embodiment 1

[0054] Add F-127 to the 1 mg / mL graphene oxide aqueous dispersion to make the final F-127 concentration 25 mg / mL, disperse it evenly by magnetic stirring, and place it for use. Add hydroxyethyl methacrylate (HEMA) and N-vinylpyrrolidone (NVP) monomers according to the ratio of the amount of substances to 7.4:2, and then add the above-mentioned water-soluble graphene oxide solution to make the graphene oxide aqueous solution Accounting for 35% of the total mass of the whole monomer and graphene oxide aqueous solution mixture, add 0.5% (M APS+TMEDA :M HEMA+NVP ) ammonium persulfate (APS) and tetramethylethylenediamine (TMEDA) redox initiator, stirred evenly and poured into the mold, reacted at 60°C for 1 hour, soaked in water for demoulding, and obtained graphene oxide composite water gel. The gel time of this hydrogel is 29±2min, no obvious deformation occurs after swelling, and the equilibrium water content is 47±1%. The hydrogel was soaked in a 0.5 mg / ml puerarin aqueous s...

Embodiment 2

[0057] Add F-127 to the 0.5 mg / mL graphene oxide aqueous dispersion to make the final F-127 concentration 12.5 mg / mL, disperse it evenly by magnetic stirring, and place it for use. Add hydroxyethyl methacrylate (HEMA) and N-vinylpyrrolidone (NVP) monomers according to the ratio of the amount of substances to 7.4:2, and then add the above-mentioned water-soluble graphene oxide solution to make the graphene oxide aqueous solution Accounting for 35% of the total mass of the whole monomer and graphene oxide aqueous solution mixture, add 0.5% (M APS+TMEDA :M HEMA+NVP ) ammonium persulfate (APS) and tetramethylethylenediamine (TMEDA) redox initiator, stirred evenly and poured into the mold, reacted at 60°C for 1 hour, soaked in water for demoulding, and obtained graphene oxide composite water gel. The gel time of this hydrogel is 29±2min, no obvious deformation occurs after swelling, and the equilibrium water content is 47±1%. The hydrogel was soaked in a 0.5 mg / ml puerarin aqueo...

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Abstract

The invention discloses a graphene oxide-hydrogel composite drug carrier. The graphene oxide-hydrogel composite drug carrier is prepared by polymerization of water-soluble graphene oxide, hydroxyethyl methylacrylate and N-vinyl pyrrolidone in water in the presence of a redox initiator, wherein the water-soluble graphene oxide is a graphene oxide-segmented polyether F-127 mixed aqueous solution. The graphene oxide-hydrogel composite drug carrier has good biocompatibility, good processability, good drug controlled-release capability, performances satisfying drug carrier basic-requirements, and large social and economic benefits, and can control drug release.

Description

technical field [0001] The invention belongs to the technical field of new materials, and in particular relates to the composite of graphene material and hydrogel material, the synthesis of composite hydrogel, and the loading and release of drugs in the composite hydrogel. Background technique [0002] Treatment of many diseases is accomplished through drug therapy. In this process, too low drug concentration cannot play a therapeutic role; too high drug concentration will cause side effects and even damage normal tissues and organs. In addition, the therapeutic effect also depends on whether the drug can remain in the affected area for a sufficient time. In order to improve the efficacy of drugs, it is often necessary to increase the drug concentration and the number of administrations, but too much drugs will damage normal tissues and organs. With the emergence and continuous improvement of the drug controlled release system, a new way for drug therapy has been opened up...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/34A61K47/32A61K47/04C08F226/10C08F220/28A61K47/10
Inventor 胡小红马小涵多亚如张新燕刘天宇赵尧蔡超杰
Owner 西安萱御紫金药业有限公司
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