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Hydroxy apatite hollow microsphere and its preparation method

A technology of hydroxyapatite and hollow microspheres, applied in the field of biomedical materials, can solve problems that are difficult to meet clinical and practical needs

Inactive Publication Date: 2005-03-23
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these methods have improved the performance of hydroxyapatite to a certain extent, it is still difficult to meet the high clinical and practical needs.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] (1) Spray hydroxyapatite porous particles with a particle size of 20-80 μm into the ice-water mixture of flowing double distilled water after plasma melting. The process conditions of plasma melting are: the power is 35kW, the injection distance is 300-350mm, and the powder feeding rate is 20-30g / min;

[0014] (2) Filter off the ice water, and collect the molten particles after natural drying;

[0015] (3) Wash the collected molten particles with absolute ethanol, dry them naturally, and disperse them by ultrasonic oscillation, and grade the obtained powders according to the usage requirements, pack them, and sterilize them before use.

[0016] The diameter of the prepared hollow microspheres is 20-90 μm, wherein more than 70% of the particles are hollow spheres, more than 50% of the hollow spheres have microporous walls, and the average crystallinity of hydroxyapatite is lower than 50% .

example 2

[0018] (1) The hydroxyapatite porous particles with a particle size of 120-200 μm are melted by plasma and sprayed into the ice-water mixture of flowing double distilled water. The process conditions of plasma melting are: the power is 45kW, the injection distance is 400-450mm, and the powder feeding rate is 30-40g / min;

[0019] (2) Filter off the ice water, and collect the molten particles after natural drying;

[0020] (3) Wash the collected molten particles with absolute ethanol, dry them naturally, and disperse them by ultrasonic oscillation, and grade the obtained powders according to the usage requirements, pack them, and sterilize them before use.

[0021] The diameter of the prepared hollow microspheres is 100-200 μm, wherein more than 60% of the particles are hollow spheres, more than 50% of the hollow spheres have microporous walls, and the average crystallinity of hydroxyapatite is lower than 60% .

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PUM

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Abstract

A bioactive degradable hollow hydroxy apatite microball used as carrier is prepared from porous hydroxy apatite particles through plasma fusing, spraying it in low-temp medium, natural drying, washing, ultrasonic dispersing and collecting.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a bioactive hydroxyapatite hollow microsphere used in the fields of drug slow-release carrier, bone defect repair material, separation and purification medium and a preparation method thereof. technical background [0002] Hydroxyapatite has excellent biological safety and biological activity, and has achieved good clinical application results as a bioactive coating for implants and bone defect filling materials. Compared with other materials, hydroxyapatite has good biocompatibility, stable chemical properties, and does not produce harmful substances after dissolution and degradation. Therefore, its application in the fields of drug controlled release carriers and biological substance separation and purification media has attracted people's attention. . However, its main disadvantages as a sustained-release drug carrier are the single pore structure and low biodegradation ra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/447C04B38/08
Inventor 吕宇鹏朱瑞富王建华李士同孙瑞雪李木森
Owner SHANDONG UNIV
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