Thymalfasin chitosan / beta-cyclodextrin composite microsphere drug delivery system and preparation method

A new technology of composite microspheres and thymus method, which is applied in the field of medicine, can solve the problems of poor stability of preparations and require refrigerated storage, and achieve the effect of simple and feasible preparation process, good reproducibility, and avoiding degradation reactions

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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to provide a new thymus method new chitosan / β-cyclodextrin composite microspheres for the short half-life of the thymus method, which needs multiple administrations in a short time, and the poor stability of the preparation requires refrigerated storage. medicine system

Method used

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  • Thymalfasin chitosan / beta-cyclodextrin composite microsphere drug delivery system and preparation method
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  • Thymalfasin chitosan / beta-cyclodextrin composite microsphere drug delivery system and preparation method

Examples

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Embodiment 1

[0045] Weigh 0.2g of chitosan powder and disperse it in 10mL, 2% acetic acid aqueous solution, fully dissolve, let stand to drain the air bubbles to obtain chitosan acetic acid aqueous solution; weigh 1g of β-cyclodextrin into the reaction bottle, add 20mL to Ionized water, mechanically stirred (can be properly heated) to dissolve completely, to obtain an aqueous solution containing β-cyclodextrin; slowly add chitosan acetic acid aqueous solution to the aqueous solution containing β-cyclodextrin, stir evenly, as the water phase; Add 60 mL of liquid paraffin, 1.8 mL of span-80 and 0.3 g of dispersant magnesium stearate to another reaction bottle to form an oil phase; slowly add the water phase into the oil phase, stir until the solution is emulsified and dispersed into beads of appropriate size, Slowly add 0.5mL of 25% glutaraldehyde (crosslinking agent) solution to crosslink and solidify, stir rapidly, collect the precipitate after 2h, filter with suction, wash repeatedly with ...

Embodiment 2

[0049] Weigh 0.6g of chitosan powder and disperse it in 10mL, 2% acetic acid aqueous solution, fully dissolve, let stand to drain out the air bubbles, and obtain chitosan acetic acid aqueous solution; weigh 0.6g of β-cyclodextrin into the reaction bottle, add 20mL Deionized water, mechanical stirring (can be properly heated) to dissolve completely, to obtain an aqueous solution containing β-cyclodextrin; slowly add chitosan acetic acid aqueous solution to the aqueous solution containing β-cyclodextrin, stir evenly, as the water phase; In another reaction bottle, add 120mL of a mixture of liquid paraffin and petroleum ether, 6mL of span-80 and 1g of dispersant magnesium stearate to form the oil phase; slowly add the water phase into the oil phase, stir until the solution is emulsified and dispersed to a suitable size Add 2.5mL of 25% glutaraldehyde (cross-linking agent) solution to cross-link and solidify, collect the precipitate after 2h, wash repeatedly with isopropanol three ...

Embodiment 3

[0053] Weigh 0.15g of chitosan powder and disperse it in 10mL, 2% acetic acid aqueous solution, fully dissolve, let stand to drain out the air bubbles, and obtain chitosan acetic acid aqueous solution; weigh 1.5g of β-cyclodextrin into the reaction bottle, add 20mL of deionized water, mechanically stirred (can be properly heated) to dissolve completely, to obtain an aqueous solution containing β-cyclodextrin; slowly add chitosan acetic acid aqueous solution to the aqueous solution containing β-cyclodextrin, stir evenly, as the water phase ;Add 30mL liquid paraffin, 15mL span-80 and 1.5g dispersant magnesium stearate to another reaction bottle to form the oil phase; slowly add the water phase to the oil phase, stir until the solution is emulsified and dispersed into beads of appropriate size , adding 0.6 mL of 25% glutaraldehyde (cross-linking agent) solution to cross-link and solidify, collect the precipitate after 2 hours, wash repeatedly with ethanol three times, and dry to o...

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Abstract

The invention relates to a novel thymalfasin chitosan / beta-cyclodextrin composite microsphere drug delivery system and a preparation method. Chitosan serves as a membrane material, beta-cyclodextrin serves as a clathration material, and a composite microsphere is prepared in a reversed phase suspension-chemical crosslinking method. According to the novel thymalfasin chitosan / beta-cyclodextrin composite microsphere drug delivery system, the composite microsphere carries thymalfasin. According to the novel thymalfasin drug delivery system, the obtained composite microsphere performs good protection and controlled-release functions on the thymalfasin, provides feasibility for oral administration medicines and has good economic benefits and application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a novel thymus-process new chitosan / beta-cyclodextrin composite microsphere drug delivery system and a preparation method. Background technique [0002] Thymalfasin (Thymalfasin) is the main component of thymosin component 5 (T5). It is an acidic polypeptide acetylated at the N-terminus. It consists of 28 amino acid residues. Its relative molecular mass is 3108.3 and its isoelectric point is 4.2. Chemically synthesized commodity, its activity is 10-1000 times that of T5, which is a biological response regulator, which can promote the T cell maturation of peripheral blood lymphocytes activated by mitogens, and increase the ability of T cells to respond to various antigens or mitogens. After activation, various lymphokines are produced. [0003] Thymofasin has two main functions: on the one hand, it has immune regulation ability, and on the other hand, it has antivira...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K38/22A61K47/40A61K47/36A61K39/39A61P31/12A61P31/18A61P35/00A61P31/14A61P31/20A61P37/04
Inventor 王学文李玲梅张志生孙晔杜丽丽陈超于云龙
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