53 results about "Response regulator" patented technology

The invention provides a method for alleviating pain associated with neuromuscular or skeletal injury or inflammation by controlled and directed delivery of one or more biological response modifiers to inhibit the inflammatory response which ultimately causes acute or chronic pain. Controlled and directed delivery can be provided by implantable or infusion pumps, implantable controlled release devices, or by sustained release compositions comprising biological response modifiers.

The present Invention relates to a method of treating abnormal cell growth in a subject, comprising administering to said subject having abnormal cell growth: (a) a compound selected from the group consisting of a camptothecin, a camptothecin derivative, or a pharmaceutically acceptable salt, solvate or prodrug of said compounds; (b) a pyrimidine derivative or a pharmaceutically acceptable salt, solvate or prodrug of said pyrimidine derivative; and (c) an anti-tumor agent selected from the group consisting of antiproliferative agents, kinase inhibitors, angiogenesis inhibitors, growth factor inhibitors, cox-I inhibitors, cox-II inhibitors, mitotic inhibitors, alkylating agents, anti-metabolites, intercalating antibiotics, growth factor inhibitors, radiation, cell cycle inhibitors, enzymes, topoisomerase inhibitors, biological response modifiers, antibodies, cytotoxics, anti-hormones, anti-androgens and combinations thereof.

An invention that adduces cogent evidence to establish that oxygenated dibenzo-α-pyrones (DBPs and their conjugates), the major bioactives of shilajit (Ayurvedic vitalizer), have their origin, at least partly, in EPA and DHA. Earlier research has shown that, in mammals, C-20 PUFAs are metabolized by oxygenases and other enzymes to produce short-lived prostaglandins, leukotrienes and thromboxanes that bind to specific G-protein-coupled receptors and signal cellular responses, e.g., inflammation, vasodilation, blood pressure, pain etc. But never before it was suggested/shown that C_20:5n-3 (and C_{22:6 n-3}) PUFAs, e.g., EPA (and DHA), are transformed into stable aromatic metabolites, DBPs, which elicit a large array of bioactivities in the producer organisms and also control the synthesis and metabolism of arachidonate-derived prostaglandins. The major beneficial effects attributed to EPA and DHA are now found to be largely contributed by DBPs and their aminoacyl conjugates and the dibenzo-α-pyrone-chromoproteins (DCPs). Because of the highly unstable nature of EPA and DHA, when administered, they are metabolized into a large array of uncontrolled products, several of which are systemically undesirable. By contrast, DBPs, because of their stability, perform the biological response modifier (BRM) functions in a directed and sustained way. Many of the biological effects of DBPs described in this invention, were earlier attributed to EPA and DHA,—the precursors of DBPs.

This disclosure concerns methods for evaluating inflammatory cells and modulators of the inflammatory response in tumor tissue and other relevant tissue types. The methods entail: obtaining a tissue sample and processing said tissue sample to produce histologic slides of tissue sections; staining of the tissue sections to identify inflammatory cells and modulators of the inflammatory response; digitizing slides to produce an image of the stained tissue sections; digitally stratifying the tissue sample into tumor and other relevant tissue compartments; and using digital image analysis to quantify cell-based and cell population-based features. The quantification of cell-based and cell population-based features within a tissue compartment of interest is used to develop a summary score of the immune system-tissue compartment of interest interaction. Patient stratification and selection as candidates for a therapeutic approach is ultimately based on the summary score value.

The invention provides a method for preparing a high-purity lower fatty acid ester. The method is characterized in that proper amount of water or C1-C6 alcohol is adopted as a reaction conditioner; and C2-C6 olefin and C1-C5 organic carboxylic acid are introduced into a reaction system containing a strong acid catalyst so as to carry out an addition reaction to generate the lower fatty acid ester. The addition of the reaction conditioner of the water or the C1-C6 alcohol can accelerate the acid-olefin addition reaction, inhibit side reactions such as the olefin polymerization, and prevent the coking of diolefin on the surface of the catalyst, thereby generating the lower fatty acid ester through the high-selectivity addition of olefin and carboxylic acid, and greatly prolonging the service life of the catalyst.

The invention generally features methods for increasing yield, shoot formation, and delaying senesence in plants with the use of transgenes that regulate the cytokinin response. The invention also features plants and plant components that harbor the transgene(s).

The invention discloses a composite additive and a refractory castable. The composite additive comprises the following components in percentage by weight: 20-60 percent of hydration reaction regulator, 20-50 percent of dispersing agent and 40-80 percent of matrix components. According to the composite additive, initial ion concentration of OH<-> regulated by the hydration reaction regulator is extremely low, so that a hydration reaction of calcium aluminate cement can be inhibited in a certain time, and the refractory castable keeps excellent liquidity in long enough time, i.e., enough working time is provided for construction operation. Moreover, after construction is ended, the ion concentration of OH<-> rapidly rises, so that the refractory castable is rapidly solidified and hardened, the maintenance time is shortened, the refractory castable has relatively high early strength, and the construction efficiency is improved.

The invention provides a multilayer high-frequency printed circuit board copper foil surface coarsening solution and a coarsening method thereof, and belongs to the technical field of printed circuit manufacturing. The copper foil coarsening solution comprises the components of hydrogen peroxide, sulfuric acid, phosphoric acid, a copper coordination agent, a corrosion inhibitor and the like, wherein the phosphoric acid, the copper coordination agent and the corrosion inhibitor form a reaction adjusting system, the oxidation reduction and the dissolution precipitation are skillfully fused together by adding a reaction regulator, and a layer of substance benzotriazole with strong affinity with resin is generated on the surface of the treated copper foil, so that organic consideration of surface coarsening and interlayer binding force of the copper foil is realized. Due to the fact that the copper reaction activity of the phosphoric acid system is low, air plasma activation is added before coarsening of the surface of the copper foil, high-activity particles such as electrons, positive ions, neutral particles and the like existing in the air plasma are utilized to activate copper, and then the treatment efficiency is improved.

The invention provides a process for preparing silicone-containing addition polymers by means of free-radical addition polymerization of one or more ethylenically unsaturated organic monomers in the presence of copper-free free-radical initiator and of one or more polymerization regulators, characterized in that the polymerization regulators used comprise silicones containing at least one aldehyde group.

The present invention provides anticancer biological response modifier for the treatment of cancer. In accordance with an aspect of the present invention, there is provided a composition for the treatment of breast and prostate cancer in a mammal, said composition comprising small molecular weight components of less than 3000 daltons, and having the following properties: is extracted from bile of animals; is capable of stimulating monocytes and/or macrophages in vitro and/or in vivo; is capable of modulating tumor necrosis factor production and/or release; contains no measurable level of IL-1α, IL-1β, TNF, IL-6, IL-8, IL-4, GM-CSF or IFN-gamma; is not cytotoxic to human peripheral blood mononuclear cells; is not an endotoxin; and optionally with (ii) one or more anticancer agent(s), wherein said combination has therapeutic synergy or improves the therapeutic index in the treatment of cancer over the composition or the anticancer agent(s) alone. Another aspect of the present invention provides the use of this composition or combination in the manufacture of a medicament for the treatment of breast or prostate cancer in a mammal.

An object of the present invention is to provide nucleic acids capable of imparting high-yielding ability to plants. Another object of the present invention is to use such nucleic acids to produce transgenic plants at increased yield, as well as to provide methods for increasing the yield of plants. By introducing into a plant a construct in which a promoter of a pseudo-response regulator gene in O. longistaminata and/or a structural gene of a pseudo-response regulator in a plant are operably linked, a transgenic plant is obtained that has acquired high-yielding ability.

A silicone ink composition for inkjet printing which is composed of an organopolysiloxane having two or more alkenyl groups on the molecule, an organohydrogenpolysiloxane having two or more hydrosilyl groups on the molecule, a platinum catalyst, a reaction regulator, a pigment, a dispersant and a solvent lends itself well to use in printing and coating with an inkjet printer. An image can be formed by using an inkjet printer to print or coat the composition onto a recording medium, then crosslinking and/or bonding the composition.

The invention relates to a grape cytokinin response regulator VvRR gene and an encoded protein and application thereof, and belongs to the technical field of plant genetic engineering. The invention utilizes the transgenic technology of a driving principle by a strong promoter to transfer an over-expression vector of the VvRR gene into a tomato, thereby obtaining transgenic tomato plants. Experimental results show that, compared with wild-type tomato plants, the fruit setting rate of transgenic tomato plants with over-expressed VvRR gene is significantly increased. This indicates that the VvRRgene is closely related to the fruit setting rate, and therefore, the VvRR gene may be used to improve the fruit setting rate of plants.

A deposition method modulates the reaction rate and thickness of highly conformal dielectric films deposited by forming a saturated catalytic layer on the surface and then exposing the surface to silicon-containing precursor gas and a reaction modulator, which may accelerate or quench the reaction. The modulator may be added before, after, or during exposure of the silicon-containing precursor gas. The film thickness after one cycle of deposition may be increased up to 20 times or decreased up to 20 times.

Kitchen oil comes from the cooking process and needs to be cleaned frequently, otherwise it will not only affect the appearance, but also breed bacteria. Most of the existing detergent products contain strong alkaline components, volatile solvent components, oxidizing components, enzyme preparation components or components that are obviously harmful to the environment, which may have adverse effects on utensils, human bodies and the environment. Therefore, the present invention provides an environment-friendly high-efficiency kitchen oil stain cleaner, which comprises the following raw materials in weight percentage: 0.1-10% composite surfactant, 1-20% contact regulator, 1.5-40% reaction regulator, ion regulator 0.02-2% agent, and the rest is water, which has the advantages of high oil removal efficiency, safety and non-irritation, no obvious odor, no oxidation, stable and reliable.

An improved and efficient method of producing a composition containing a metal peroxide capable of enhancing microbial degradation of contaminants in soil and groundwater. The method includes reacting a metal oxide or metal hydroxide with hydrogen peroxide in a solution of water containing a reaction moderator, intercalation agent, and a gelling agent.

The invention discloses a responsive bandwidth adjustment method of the Internet of Things based on forward task estimation. The method includes: forward task estimation, an application layer priority management strategy and a responsive bandwidth adjustment algorithm. Forward task estimation solves the problem of wasting the expected authorized bandwidth at the terminal layer; the application layer priority management strategy is a weight and weight of the influencing factors based on the application layer priority modeling, and then realizes the application of the application layer task priority It not only has programmable input, but also focuses on solving the problem of adaptive adjustment of variable priority tasks; the responsive bandwidth adjustment algorithm provides quality support for the completion of target tasks, and can quickly Adjust bandwidth in response to overall network bandwidth requests. The method has a simple structure, strong overall resource planning, and has no special requirements for network equipment, and is especially suitable for responsive adjustment of narrowband IoT bandwidth with heavy terminal tasks.