41 results about "Host response" patented technology

The present invention encompasses topical oral care compositions comprising the combination of an anti-bacterial agent with an anti-inflammatory agent in an orally acceptable carrier for effective treatment and prevention of bacteria-mediated diseases and conditions in the oral cavity and for modulating host reaction to bacterial pathogens present in the oral cavity and to the toxins, endotoxins, inflammatory cytokines and mediators released by or prompted by these pathogens. The present invention also encompasses methods of use of these compositions comprising topical application to the oral cavity. The benefits of the present compositions and methods extend beyond treating and preventing oral bacterial infections in the oral cavity to promoting whole body or systemic health.

Disclosed are preparations of placentally-derived stem cells and compositions useful for the treatment of cancer. Said stem cells and compositions function through inducing a “guided differentiation” program in cancer cells, thereby reducing malignancy. Further extension of the invention pertains to augmenting ability of administered cells to induce differentiation through the co-administration of known differentiation inducing agents. Within the context of this disclosure, methods for inducing host responses to cancer are also described.

The present invention relates to an avirulent, oncolytic herpes simplex virus modified from a wild-type herpes simplex virus so that both γ134.5 genes of the virus have been deleted and each replaced with an interferon-resistance gene that is expressed as an immediate-early gene. The present invention also relates to a pharmaceutical composition that includes the modified herpes simplex virus of the present invention and a pharmaceutically acceptable vehicle for in situ administration to tumor cells. Also provided in the present invention are methods for killing tumor cells in a subject and for immunizing a subject against an infectious disease, cancer, or an autoimmune disease that involve administering to a subject the modified avirulent, oncolytic herpes simplex virus of the present invention.

The present invention provides a specific set of gene expression markers from peripheral blood leukocytes that are indicative of a host response to exposure, response, and recovery infectious pathogen infections. The present invention further provides methods for identifying the specific set of gene expression markers, methods of monitoring disease progression and treatment of infectious pathogen infections, methods of prognosing the onset of an infectious pathogen infection, and methods of diagnosing an infectious pathogen infection and identifying the pathogen involved.

The present invention encompasses topical oral care compositions comprising the combination of an anti-bacterial agent with an anti-inflammatory agent in an orally acceptable carrier for effective treatment and prevention of bacteria-mediated diseases and conditions in the oral cavity and for modulating host reaction to bacterial pathogens present in the oral cavity and to the toxins, endotoxins, inflammatory cytokines and mediators released by or prompted by these pathogens. The present invention also encompasses methods of use of these compositions comprising topical application to the oral cavity. The benefits of the present compositions and methods extend beyond treating and preventing oral bacterial infections in the oral cavity to promoting whole body or systemic health.

The present invention relates to promoting whole body health in humans and animals by using topical oral compositions comprising a safe and effective amount of a host-response modulating agent in admixture with a pharmaceutically acceptable carrier, said compositions being effective in mediating host reaction to the presence of periodontal pathogens in the oral cavity as well as the toxins and endotoxins released by these pathogens and the inflammatory cytokines and mediators prompted by these oral pathogens.

A remote wake-up method is used between a first host, a second host, a server and the internet. The remote wake-up method includes the following steps. Firstly, the first host communicates with the server through the internet and an identity register procedure is performed. Then, the second host communicates with the server through the internet, an identity authentication procedure is implemented, and the server is triggered to issue a wake-up packet to the first host when the first host is in a wake-up waiting status. Afterwards, the first host enters a normal working status in response to the wake-up packet.

Methods of specifically detecting host response protein clusters and of correlating patterns of expression of these clusters with various clinical parameters are provided.

The invention discloses an online expansion system of disk array and a relative method, which can effectively treat the impacted user read and write requests to effectively eliminate user waiting in expansion, and uses bit map to record the progress of the expansion operation and the expansion states of different addresses, thereby effectively reducing the expansion effect on read and write functions to effectively improve the host response speed in expansion process. The invention is suitable for online expansion of disk array capacity of computer storage system.

A mechanism for bottleneck avoidance is provided in an intelligent adapter. The mechanism allows the adapter to be used such that host / adapter system throughput is optimized. The bottleneck avoidance mechanism of the present invention determines when the adapter becomes a bottleneck. If certain conditions exist, then new connections are refused so that the adapter can process packets for existing connections. If certain other conditions exist, the adapter may migrate workload to the host processor for processing. These conditions may be determined by comparing memory usage or central processing unit usage to predetermined thresholds. Alternatively, the conditions may be determined by comparing adapter response time to host response time.

Disclosed is a controller and method for regulating a power-down mode in a memory card system. The memory card controller includes a central processor unit, a direct memory accessing (DMA) unit, a buffer, and a power-down detector. The central processor unit accepts commands from a host and the DMA unit stores the number of blocks requested by the host in response to instructions of the central processor unit. The buffer stores data that are read from an external storage device through the DMA unit. The power-down detector outputs a control signal to regulate a system clock by means of detecting a storage condition of the buffer and a read-out condition of the host. As the power-down mode begins, if the host does not read data stored in the buffer even when the buffer is full with data, it is possible to reduce power consumption by the memory card controller.

Disclosed are methods and apparatus for diagnosis, detection of host response, monitoring, treatment or management of sepsis, infection-negative systemic inflammatory response syndrome (SIRS) and post-surgical inflammation in mammals. More particularly, the present invention discloses marker genes and their splice variant transcripts as well as their expression products, which are useful for distinguishing between sepsis and infection-negative SIRS, including post-surgical inflammation, and to the use of these markers in grading, monitoring, treatment and management of these conditions.

A method of a host computer processing peripheral interrupt comprises the steps as follows: storing interrupt type identification of responsive interrupt of each type in the host computer; outputting information to a communication port between an interrupt subprogram and a host computer after the peripheral generates the interrupt and before the corresponding interrupt subprogram is dispatched to conduct implementing functions, or after the interrupt is ended; the information contains an interrupt type identification and a status indication identification of the interrupt, and the value of the status indication identification correspondingly shows that the interrupt is generated or ended; when the host computer detects information received by the communication port, if the generation of the interrupt is judged according to the value of the status indication identification, whether the interrupt type identification carried in the information is stored in the local area is judged; if yes, the interrupt responded; if the ending status of the peripheral interrupt is judged according to the value of the status indication identification, whether the interrupt type identification carried in the information is stored in the local area is judged; if yes, the response interrupt is stopped. The invention solves the problem of buffer overflow caused by too long peripheral interrupt time.

Novel compositions useful as influenza immunogens are provided. The compositions enable a host response to immunogen sites normally not recognized by a host.

The invention relates to the technical field of display, and discloses a method for displaying service logic and performance states at the same time. Specifically, the method comprises the steps of 1, deploying probes on nodes in a network, obtaining communication data through the probes, analyzing the communication data to obtain access relationships among hosts, thereby forming a service logic graph of the access relationships among the hosts, moreover, analyzing applications in the hosts according to the communication data, and adding graph representation of the applications beside the hosts of the service logic graph of the access relationships; and 2, analyzing a network transmission performance parameter, an application response performance parameter and a host response performance parameter in the network, providing judging results of the performance states according to the values of the three parameters, and graphically representing the judging results of the performance states on the service logic graph of the access relationships. Through adoption of the method, the service logic and performance states can be displayed on the same visual graph, thereby facilitating the usage of a user.

The present invention relates to an avirulent, oncolytic herpes simplex virus modified from a wild-type herpes simplex virus so that both γ134.5 genes of the virus have been deleted and each replaced with an interferon-resistance gene that is expressed as an immediate-early gene. The present invention also relates to a pharmaceutical composition that includes the modified herpes simplex virus of the present invention and a pharmaceutically acceptable vehicle for in situ administration to tumor cells. Also provided in the present invention are methods for killing tumor cells in a subject and for immunizing a subject against an infectious disease, cancer, or an autoimmune disease that involve administering to a subject the modified avirulent, oncolytic herpes simplex virus of the present invention.

The present invention relates, inter alia, to methods and compositions for regulating the host response to biomaterials, including inhibiting inflammation from and rejection of biomaterials using salicylate compounds and / or TLR7 / TLR9 antagonists as described herein.

The invention provides a portable performance testing instrument of an automatic neutral-section passing control system and a testing method. The testing instrument simulates states of forward operations of a I end and a II end of a locomotive and connects the states to an automatic neutral-section passing host; signal pulses conforming to input requirements of the automatic neutral-section passing host are inputted into input ports of different vehicle sensing devices to trigger outputting of a forced signal and a predictive / recovery signal of the automatic neutral-section passing host; and during the process, the sensitivity, output amplitude, output pulse width, output drive capability, and host response time of the automatic neutral-section passing host are tested. Therefore, under thecircumstance that the host does not need to be dismounted from the locomotive, the performance of the host is tested by the simple operation. Besides, the testing instrument has advantages of simplestructure, high portability, accurate measurement and fast testing speed.

A method for determining the contents of a host response to a client query by detecting patterns expected in the data displayed in the host response, and outputting the data in the format of the detected pattern to the client. The pattern may be expressed using extensible markup language and regular expressions to form a compact and precise notation for the pattern.

Disclosed are methods of preparing and using placentally-derived stem cells and compositions useful for the treatment of cancer. Said stem cells and compositions function through inducing a “guided differentiation” program in cancer cells, thereby reducing malignancy. Further extension of the invention pertains to augmenting ability of administered cells to induce differentiation through the co-administration of known differentiation inducing agents. Within the context of this disclosure, methods for inducing host responses to cancer are also described.

The present disclosure is directed to methods of detecting cell-free DNA (cfDNA) in biological samples and using it to quantify organ damage and identify pathogens. In some aspects, the biological samples are from patients who have undergone solid-organ transplantation. The disclosure is also directed to methods of detecting and analyzing methylation patterns in cell-free DNA from organ transplant patients to identify the presence of pathogens as well as quantify contributing tissue proportions as a measurement of the host response.

The present disclosure relates to compositions and methods for inhibiting inflammation and reducing the risk of spreading sexually transmitted diseases using an alginic acid-based antimicrobial compound. Such compositions provide dual protection by (1) attacking and inactivating viruses and other microbes and (2) blocking the host response that viruses trigger to invade host cells. Such compositions can also be part of an acid buffering contraceptive.

Novel compositions useful as influenza immunogens are provided. The compositions enable a host response to immunogen sites normally not recognized by a host.

Methods for providing novel compositions useful as influenza immunogens are provided. The compositions enable a host response to immunogen sites normally not recognized by a host. The novel immunogens can be used as vaccines or to develop antibodies.

Sepsis is a complex, incompletely understood and often fatal disorder, typically accompanied by hypotension, that is considered to represent a dysregulated host response to an infection. Neurotensin (NT) is 13-amino-acid peptide that, among its multiple effects, induces hypotension. It is shown herein that plasma concentrations of NT are increased in humans with sepsis and in mice after caecal ligation and puncture (CLP), a model of sepsis. Mast cells can degrade NT through neurotensin receptor 1-and neurolysin-dependent mechanisms, diminishing the hypotensive effects of NT, reducing intraperitoneal NT concentrations, and improving survival. These findings show that mast cells can regulate NT concentrations, and identify NT as a biomarker and therapeutic target in sepsis.

The invention discloses a remote control method for reflecting infrared light through a reflection remote control handle. The remote control method comprises the following steps: 1, an infrared emitter emits infrared light, the reflector of the reflection remote control handle reflects infrared light on the reflector, and an infrared camera receives the reflected infrared light, forms an infrared image identification point and transmits to a controller; 2, a shielding sheet shields the middle portion of the reflector, two reflection areas are formed at two sides of the shielding sheet, and the infrared camera receives infrared light reflected by the two reflection areas, forms two infrared image identification points and transmits to the controller; 3, a first control signal is sent when the number of the infrared image identification point received by the controller becomes 2 from 1, and a host responses the first control signal; 4, the shielding sheet is removed, a second control signal is sent when the number of the infrared image identification point received by the controller becomes 1 from 2, and the host responses the second control signal; and 5, steps 1-4 are repeated. The remote control method can realize the remote control operation of the host without a button, and has the advantages of simple and convenient operation, accurate remote control, and prolongation of the service life of the reflection remote control handle.