Portable high-voltage nanosecond squarer

Abstract

The invention relates to a portable high-voltage nanosecond squarer which belongs to a medicinal device for inducing cancer cell apoptosis by using a high-voltage nanosecond square wave pulse electric field. The portable high-voltage nanosecond squarer mainly comprises a power supply system, a high-voltage direct current module, a low-voltage power supply, a pulse forming system and a pulse shaping and counting system. The portable high-voltage nanosecond squarer has output pulses with highest amplitude of 15kV, pulse width adjustment range of 50ns-1us, rising edge gradient of reaching 10ns and controllable recurrence frequency of 0.2-15Hz; and the quantity of the output pulses of the portable high-voltage nanosecond squarer can be set. The portable high-voltage nanosecond squarer can be adjusted in multiple-parameters (pulse amplitude, pulse width, recurrence frequency, pulse quantity and the like), large-range and flexible and independent way, and is beneficial to researching the optimal window parameter of the cancer cell apoptosis and promoting the cancer cell apoptosis as well as improving the cancer treatment effect. Meanwhile, the portable high-voltage nanosecond squarer has compact and light structure, reliable work, simple operation and convenient popularization and application, and can be widely applied to the treatment of various cancers.

Description

technical field [0001] The invention belongs to the field of bio-electromagnetic technology, in particular to a medical device for inducing apoptosis of tumor cells by a high-voltage nanosecond pulsed electric field. Background technique [0002] At present, the impact of pulsed electric field on cell structure and function and its therapeutic effect on organisms have gradually become a research hotspot in the field of bioelectromagnetic technology. Studies have shown that when the pulse width is reduced to the nanosecond (ns) level and the electric field strength is increased to 10kV / cm and above, this nanosecond pulsed electric field brings a series of cell responses that are completely different from the electroporation phenomenon, although There is no obvious electroporation phenomenon on the surface of the cell membrane, but a series of functions such as phosphatidylserine externalization, activation of cysteine ​​proteases (Caspases), release of calcium ions, fragmenta...

AI Technical Summary

Problems solved by technology

The device mainly has the following deficiencies in medical practice: the output pulse amplitude is too low, and it cannot generate higher-intensity nanosecond pulse electric fields to act on tumor cells, which limits the application range of the device; the output pulse width adjustment range is limited (minimum 200ns ), and cannot include all nanosecond pulse width parameters, which cannot meet the needs of nanosecond pulse electric field tumor cell electrical treatment effect window parameter selection; pulse rising edge is gentle, ignoring the influence of high frequency components on tumor cell electrical treatment effect ;The output pulse is an exponentially decaying pulse, and the equivalent frequency of the pulse is complex, which is not conducive to the spectrum analysis of the pulse parameters; the number of output pulses of the device is uncontrollable, and the therapeutic dose of the pulse acting on the tumor cells cannot be effectively controlled

The above-mentioned shortcomings of the device are not conducive to seeking the optimal pulse treatment window parameters for tumor cell apoptosis while normal cells are not affected in medical experiments, which in turn affects the effect of tumor cell therapy

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