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New target for regulating and controlling tumor cell metastasis and application thereof

A tumor cell and tumor technology, used in the prediction, diagnosis and treatment of tumor cell metastasis, molecular biology and tumor prevention and treatment, to reduce the metastasis of malignant tumor, improve the effect of tumor treatment, and promote the effect of migration

Inactive Publication Date: 2016-10-12
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, little is known about the mechanistic role of DcR3 in cell adhesion and cell migration, especially its relation to tumor metastasis

Method used

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  • New target for regulating and controlling tumor cell metastasis and application thereof
  • New target for regulating and controlling tumor cell metastasis and application thereof
  • New target for regulating and controlling tumor cell metastasis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] (1) In vitro culture experiment

[0045] In this example, high-sugar DMEM (gibico) + 10% FBS (hyclone) was used as the medium in a 6-well plate at 37°C and 5% CO 2 Three groups of HepG2 tumor cells were cultured in vitro for 72 hours, and the cell density was 1×10 5 One group was not treated, and the other two groups added IgG1 and DcR3-Fc at a final concentration of 3 μg / ml to the culture medium. The result is as figure 2 As shown, the experimental results showed that the cell morphology and cytoskeleton of tumor cells cultured in vitro changed significantly under the condition of DcR3 treatment. In the case of low cell density, after 72 hours of culture, cells in the control group (without treatment group and IgG1 group) were compactly combined to form clonal aggregation growth, while cells in the DcR3 (3 μg / ml) treatment group were significantly changed. The cells grow loosely and dispersely, and at the same time, the cell morphology and skeleton appear obvious c...

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Abstract

The invention provides a new target for regulating and controlling tumor cell metastasis and an application thereof; the application is an application of a DcR3 inhibitor in preparation of medicines for reducing or eliminating tumor cell metastasis. The invention discloses a new mechanism of the DcR3 in regulation and control of tumor metastasis, and the DcR3 is clear and definite to be used as an anti-tumor migration target; through studies, the DcR3 is indicated to be capable of regulating and controlling expression of crucial molecule E-cadherins in an EMT generation process, promote tumor cytoskeleton remodeling, and then promote the migration of tumor cells. In general, the application can reduce or alleviate malignant tumor metastasis, thereby playing a role in improving the effect of tumor therapy.

Description

technical field [0001] The invention belongs to the field of molecular biology and tumor prevention and treatment, more specifically, the invention relates to the field of prediction, diagnosis and treatment of tumor cell metastasis. Background technique [0002] Malignant tumors are a class of diseases that endanger human health. Chemotherapy is one of the main methods for treating malignant tumors. However, metastasis of malignant tumors often leads to failure of tumor chemotherapy. Therefore, the research on the mechanism of malignant tumor metastasis and the search and development of drugs to reduce or eliminate malignant tumor metastasis are the key points and difficulties in the field of cancer prevention and treatment research. [0003] The metastasis of tumor cells is an extremely complex process, including the degradation of extracellular matrix (EMC) and cell movement. During the invasion and metastasis of cancer cells, a series of tissue barriers will be encounte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K48/00A61K31/713A61K49/00A61P35/04C12N15/113G01N33/574
CPCA61K31/713A61K45/00A61K49/0008C12N15/1135G01N33/57484
Inventor 万晓春张宏玲
Owner SHENZHEN INST OF ADVANCED TECH
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