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GTR film, and preparation method and application thereof

ActiveCN120324686BAddressing drug resistancedeep penetrationSurgeryElectro-spinningFiberElectrospinning
This invention discloses a GTR membrane, its preparation method, and its application, belonging to the field of biomedical materials technology, and solves the problem of insufficient antibacterial effect of existing GTR membranes. The method includes the following steps: uniformly dispersing BaTiO3 in a Tris buffer solution; dissolving dopamine hydrochloride powder in the reaction system; stirring evenly; centrifuging to collect the precipitate; cleaning and drying to obtain PDA@BaTiO3 nanoparticles; adding the PDA@BaTiO3 nanoparticles to a silver ammonia solution; stirring at room temperature; centrifuging to collect the precipitate; cleaning and drying to obtain Ag@PDA@BaTiO3 particles; uniformly dispersing the Ag@PDA@BaTiO3 particles in a hexafluoroisopropanol solution of L-polylactic acid; electrospinning the reaction system to obtain a fiber membrane; and sequentially subjecting the membrane to ventilation, high-temperature annealing, and natural cooling to room temperature to obtain the GTR membrane. The GTR membrane provided by this invention possesses both piezoelectric and photothermal effects, exhibits rapid sterilization and long-lasting antibacterial activity, and has a simple preparation process.
Owner:SICHUAN UNIV