Immunologic adjuvant functionalized metal organic framework material as well as preparation method and application thereof

A metal organic framework and immune adjuvant technology, applied in the preparation and application of immune adjuvant functionalized materials, can solve the problems of long degradation cycle of carrier materials, low photosensitive drug loading efficiency, and high early release rate, and achieve excellent singlet state. Oxygen generation ability, excellent photothermal conversion ability, the effect of improving the therapeutic effect
CN112007170AActive Publication Date: 2020-12-01DERMATOLOGY HOSPITAL SOUTHERN MEDICAL UNIV (GUANGDONG PROVINCIAL DERMATOLOGY HOSPITAL GUANGDONG PROVINCIAL CENT FOR STI & SKIN DISEASES CONTROL & PREVENTION RES CENT FOR LEPROSY CONTROL & PREVENTION CHINA)
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DERMATOLOGY HOSPITAL SOUTHERN MEDICAL UNIV (GUANGDONG PROVINCIAL DERMATOLOGY HOSPITAL GUANGDONG PROVINCIAL CENT FOR STI & SKIN DISEASES CONTROL & PREVENTION RES CENT FOR LEPROSY CONTROL & PREVENTION CHINA)
Publication Date
2020-12-01

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Abstract

The invention discloses an immunologic adjuvant functionalized metal organic framework material as well as a preparation method and application thereof. The preparation process comprises the followingsteps: synthesizing MIL-101-NH2, namely MOF, combining ICG with MOF to form MOF-ICG, and loading CpG on MOF-ICG. The material can be applied to preparation of medicines. The material has the advantages that (1) the ultraviolet-visible absorption spectrum peak value of the material provided by the invention is about near-infrared light; the near-infrared laser with single wavelength can be used for exciting photodynamic and photothermal effects at the same time, has excellent singlet oxygen generation capability and photothermal conversion capability under the irradiation of the near-infraredlaser, and has huge application potential in the aspect of tumor phototherapy; (2) in a tumor microenvironment, the material-loaded CpG and TAA released by photodynamic and photothermal therapy jointly activate an immune system, so that the tumor cytotoxicity is enhanced, and the treatment effect is improved; and (3) the material provided by the invention has a tumor multi-modal imaging (fluorescence, photoacoustic, photo-thermal and nuclear magnetic resonance) function, and can be used for monitoring the tumor position and the treatment effect.
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Description

technical field

[0001] The invention relates to the technical field of a photodynamic and photothermal therapy carrier, in particular to the preparation and application of an immune adjuvant functionalized material. Background technique

[0002] Photodynamic and photothermal therapy, as a promising therapeutic method, has received more and more attention in the field of tumor treatment. In recent years, a variety of nanocarrier systems have greatly improved the bioavailability and tumor enrichment rate of photosensitive molecules, but there are still many problems such as potential toxicity, low photosensitive drug loading efficiency and high early release rate. This is attributed to the fact that the introduced carrier material has a long degradation cycle or even cannot be degraded, and the loading of photosensitive drugs is limited to non-covalent interactions, and no covalent interaction force is introduced, which greatly reduces the stability of the carrier system. Usi...

Claims

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