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Polymer composite microsphere, preparation method and drug loading application thereof

A technology of composite microspheres and polymers, applied in the direction of antineoplastic drugs, microcapsules, nanocapsules, etc., to achieve the effect of simple and easy preparation method

Inactive Publication Date: 2019-08-02
CHANGAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the defects and deficiencies of the existing preparation technology, the present invention provides a polymer composite microsphere, a preparation method and its drug-carrying application, which solves the problems existing in photothermal therapy reagents and traditional tumor drug therapy, and prepares a photothermal / drug-loading nanospheres

Method used

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  • Polymer composite microsphere, preparation method and drug loading application thereof
  • Polymer composite microsphere, preparation method and drug loading application thereof
  • Polymer composite microsphere, preparation method and drug loading application thereof

Examples

Experimental program
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Embodiment 1

[0042] According to the above technical solution, this embodiment provides a polymer composite microsphere and a preparation method.

[0043] Include the following steps:

[0044] Step 1: adding dopamine hydrochloride (DA·HCl) to the solvent and reacting in a warm water bath to prepare PDA (polydopamine) nanospheres with good light-to-heat conversion performance. Take 40mL of ethanol, 90mL of water and 3mL of concentrated ammonia water, add them to a 250mL three-necked flask in turn and stir in a 30°C water bath for 30min, maintaining a mechanical stirring rate of 250rpm. Add 0.5gDA·HCl pre-dissolved in 10mL deionized water into the three-necked flask, and react for 24h. The product was centrifuged (50000rpm, 10min), and washed with deionized water until neutral. 50 mg of PDA nanospheres were separated by centrifugation.

[0045] Step 2: using the distillation precipitation polymerization method to coat the polymer shell on the PDA nanospheres obtained in step 1 to prepare ...

Embodiment 2

[0047] Same as the method in Example 1. However, the difference from Example 1 is: accurately weigh 50 mg MAA, 1.50 mg AIBN, 5.00 mg BAC and 50 mg PDA nanospheres, and the rest of the steps are the same. Obtain polymer composite microsphere PDA@PMAA-1 (the ratio of the mass ratio of MAA and PDA is 1), such as figure 1 As shown in (c), the particle size of PDA@PMAA-1 is 190nm.

Embodiment 3

[0049] Same as the method in Example 1. However, the difference from Example 1 is: accurately weigh 100mg MAA, 3.00mgAIBN, 10mg BAC and 50mg PDA nano-microspheres, and the rest of the steps are the same. Obtain polymer composite microsphere PDA@PMAA-2 (the ratio of the mass ratio of MAA and PDA is 2), as figure 1 As shown in (d), the particle size of PDA@PMAA-2 is 227 nm.

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Abstract

The invention discloses a polymer composite microsphere, a preparation method and a drug loading application thereof. The polymer composite microsphere is characterized in that the grain size of the polymer composite microsphere is 170-350nm. The preparation method comprises the following steps: firstly, using dopamine hydrochloride for preparing a core of the composite microsphere; adding the core of the composite microsphere, methacrylic acid, cross-linking agent and initiator into a solvent; adopting a distilling precipitation polymerization method for preparing the polymer composite microsphere. The preparation method provided by the invention is simple and easy; a series of polymer composite nanospheres are acquired by coating a polymer shell layer on the exterior of the nanospheres with an excellent photo-thermal conversion performance; the polymer shell layer is capable of breaking and degrading through disulfide bond-sulfydryl exchange reaction under a reducing condition, so that the drug can be quickly and fully released; the drug therapy is capable of achieving an effect of photo-thermal therapy.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and relates to a polymer composite microsphere, a preparation method and a drug-carrying application thereof. Background technique [0002] Functional nanoparticle composite microsphere refers to a functional composite microsphere obtained by combining functional nanoparticles and microspheres by a certain method. At present, nanoparticles prepared by various methods have various special optical, electrical, magnetic and biological characteristics, so these characteristics are often endowed to the microsphere itself after being combined with the microsphere. Microspheres also provide support and effective protection for these nanoparticles. At the same time, the chemical and physical properties of the microspheres themselves, such as light sensitivity, pH responsiveness, temperature sensitivity, adsorption properties, and surface active functional groups, also provide possibilities for...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/32A61K41/00A61K31/704A61P35/00
CPCA61K9/5138A61K31/704A61K41/0052A61P35/00A61K2300/00
Inventor 田野菲颜录科晁敏雷淼
Owner CHANGAN UNIV
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