Inorganic nano MoSx/gamma-MnS composite material as well as preparation method and application thereof

A composite material and inorganic nanotechnology, applied in the field of anti-tumor, to achieve high light-to-heat conversion efficiency

Active Publication Date: 2021-12-07
INST OF HIGH ENERGY PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] However, the above-mentioned novel therapies including nanocatalytic therapy all use only one reactant O 2 、H 2 o 2 or H 2 O generates reactive oxygen species ROS (superoxide ion O 2 · - , singlet oxygen 1 o 2 or hydroxyl radical · OH), at present, the effect of nanocatalytic therapy in cancer diagnosis and treatment is still limited.

Method used

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  • Inorganic nano MoSx/gamma-MnS composite material as well as preparation method and application thereof
  • Inorganic nano MoSx/gamma-MnS composite material as well as preparation method and application thereof
  • Inorganic nano MoSx/gamma-MnS composite material as well as preparation method and application thereof

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preparation example Construction

[0037] The invention provides an inorganic nano-MoS x The preparation method of / γ-MnS composite material, preparation method comprises the steps:

[0038] Step S1, sodium molybdate (Na 2 MoO 4 ), manganese sulfate (MnSO 4 ) and cysteine ​​(L-Cys) were added into water and dissolved respectively to obtain sodium molybdate solution, manganese sulfate solution and cysteine ​​solution;

[0039] Step S2, mixing and stirring sodium molybdate solution, manganese sulfate solution and cysteine ​​solution to obtain a mixed solution;

[0040] Step S3, put the mixed solution into a polytetrafluoroethylene reactor for hydrothermal reaction, after the hydrothermal reaction, cool to room temperature, centrifuge and wash to obtain inorganic nano-MoS x / γ-MnS heterojunction composite material (hereinafter abbreviated as MoS x / γ-MnS).

[0041] Specifically, in the above step S1, the molar ratio of sodium molybdate, manganese sulfate and cysteine ​​is 2-3:1-2:8-13. Preferably, the molar ...

Embodiment 1

[0081] This embodiment provides an inorganic nano-MoS x The preparation method of / γ-MnS composite material, preparation method comprises the steps:

[0082] (1) 0.1g (0.4856mmol) sodium molybdate (Na 2 MoO 4 ), 0.0367g (0.2428mmol) manganese sulfate (MnSO 4 ) and 0.32g (2.6411mmol) cysteine ​​(L-Cys) (element molar ratio Mo:Mn=2:1) ​​were added to 3mL, 3mL, 4mL deionized water respectively, and the three solutions were mixed after ultrasonic dissolution.

[0083] (2) After the mixed solution was magnetically stirred at room temperature for 30 minutes, the mixed solution was put into a polytetrafluoroethylene reactor with a volume of 50 mL, reacted at 180 ° C for 24 hours, cooled to room temperature, centrifuged at 12000 rpm for 5 minutes, and used Washed three times alternately with ionized water and ethanol to obtain black MoS x / γ-MnS heterojunction composites.

[0084] (3) Take MoS x Add 0.01g of γ-MnS heterojunction composite material to 10mL deionized water, and add...

Embodiment 2

[0086] This embodiment provides an inorganic nano-MoS x / The preparation method of γ-MnS composite material, the first two steps of its preparation method are identical with (1)-(2) in the above-mentioned embodiment 1, do not go into details here and the preparation method comprises the following steps:

[0087] (3) Take MoS x Add 0.01g of γ-MnS heterojunction composite material to 10mL deionized water, add 0.01g gelatin and 0.005g polypeptide cRGD, sonicate until completely dissolved, stir at 1000rpm at room temperature for 6h, and centrifuge at 12000rpm for 5min , washed with deionized water to remove excess gelatin to obtain MoS x / γ-MnS@Gel-cRGD nanocomposites.

[0088] Specifically, MoS x , γ-MnS, MoS x / γ-MnS, MoS x / γ-MnS@Gel and MoS x The various related detection results of / γ-MnS@Gel-cRGD are as follows:

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Abstract

The invention discloses an inorganic nano MoSx / gamma-MnS composite material as well as a preparation method and application thereof, belongs to the technical field of tumor resistance, and overcomes the limitation of a monotherapy in the prior art. The preparation method of the inorganic nano MoSx / gamma-MnS composite material comprises the following steps: S1, respectively adding sodium molybdate, manganese sulfate and cysteine into water, and dissolving to obtain a sodium molybdate solution, a manganese sulfate solution and a cysteine solution; S2, mixing and stirring a sodium molybdate solution, a manganese sulfate solution and a cysteine solution to obtain a mixed solution; S3, putting the mixed solution into a reaction kettle for a hydrothermal reaction, after the hydrothermal reaction is finished, the mixed solution is cooled to the room temperature, centrifugation and washing are conducted, and the inorganic nanometer MoSx / gamma-MnS heterojunction composite material is obtained. The inorganic nano MoSx / gamma-MnS composite material disclosed by the invention can be applied to tumor diagnosis and treatment.

Description

technical field [0001] The invention relates to the field of anti-tumor technology, in particular to an inorganic nano-MoS x / γ-MnS composite material and its preparation method and application. Background technique [0002] Cancer is one of the killers that threaten human health, and improving the therapeutic effect of cancer has become a hot and difficult point in the field of biomedical research. The main methods of clinical cancer treatment are surgery, chemotherapy and radiation therapy. In recent years, new treatment methods including photodynamic therapy (PDT), sonodynamic therapy (SDT), radiodynamic therapy (RDT), photothermal therapy, and immunotherapy have also developed rapidly, and nanocatalytic therapy has also been used recently. tumor treatment. Nanocatalytic therapy selectively triggers catalytic chemical reactions within the tumor microenvironment (TME), mainly based on the utilization of non-toxic / low-toxic nanomaterials and the generation of toxic produ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/42A61K47/18A61P35/00A61K49/22A61K49/14
CPCA61K41/0052A61K47/42A61K47/18A61P35/00A61K49/22A61K49/14
Inventor 尹文艳王彦龙
Owner INST OF HIGH ENERGY PHYSICS CHINESE ACAD OF SCI
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