Albumin nano-particle preparation of donor-receptor type fluorescent molecule containing aggregation-induced emission group in near infrared II region

A technology of aggregation-induced luminescence and albumin nanotechnology, which is applied in the direction of medical preparations containing active ingredients, preparations for in vivo tests, non-effective ingredients of polymer compounds, etc., and can solve the problem of organic small molecule fluorescent probes that have not been retrieved problems, achieve good light-to-heat conversion ability, achieve clear imaging, and improve water solubility
CN110787305AActive Publication Date: 2020-02-14FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FUDAN UNIV
Publication Date
2020-02-14

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Abstract

The invention belongs to the field of pharmaceutical preparation, and relates to an albumin nano-particle preparation of a donor-receptor type fluorescent molecule containing an aggregation-induced emission group in a near infrared II region. By adopting an emulsifying high-pressure homogenization method, bovine serum albumin, human serum albumin or recombinant human serum albumin and the donor-receptor type fluorescent molecule containing the aggregation-induced emission group are processed so that nano-particles are prepared; albumin is bonded with the fluorescent molecule , so that rotation in the molecule is limited, molecular conformation is changed, and twisted intramolecularcharge transfer and aggregation-induced emission effect are changed, so that the nano-particle preparation having good fluorescence imaging and photothermal conversion is obtained. The nano-particle preparation can emit fluorescence in the near infrared II region under irradiation of infrared light, and a part of light energy is transformed into heat energy, and an image-guided photothermal therapy for cancers is realized. The albumin nano-particle preparation can be used for preparing a medicine for conducting fluorescence imaging and photothermal therapy in the near infrared II region (NIR-II, 1000nm to 1700nm), and the aim of integration of diagnosis and treatment is fulfilled.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to an albumin nano-preparation of a donor-acceptor fluorescent molecule in the near-infrared II region containing an aggregation-inducing luminescent group and a preparation method thereof. Background technique

[0002] The prior art discloses that malignant tumors are the number one killer threatening human health, therefore, effective diagnosis and treatment of tumors is particularly important. At present, near-infrared II region (NIR-II, 1000-1700nm) fluorescence imaging technology has gradually developed into an efficient tumor diagnosis method. Compared with near-infrared I region (NIR-I, 700-950nm) fluorescence imaging Its longer wavelength, extremely low background autofluorescence and tissue scattering interference, deeper tissue penetration, and higher spatial resolution and contrast have attracted more and more attention from scholars, doctors and pat...

Claims

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