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Near-infrared light response electrostatically spun PCL/MoS2 nanofiber membrane and preparation method thereof

A near-infrared light-responsive, nanofiber membrane technology, used in pharmaceutical formulations, textiles and papermaking, medical science, etc., can solve the problems of limited therapeutic effect and low heat transfer efficiency, and achieve good biocompatibility and high mechanical properties. , good hydrophilic effect

Active Publication Date: 2021-08-17
GUANGXI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Hyperthermia has been widely used to treat many chronic diseases since ancient times, however, it is limited by the low efficiency of heat transfer in vitro, and the therapeutic effect is relatively limited

Method used

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  • Near-infrared light response electrostatically spun PCL/MoS2 nanofiber membrane and preparation method thereof
  • Near-infrared light response electrostatically spun PCL/MoS2 nanofiber membrane and preparation method thereof
  • Near-infrared light response electrostatically spun PCL/MoS2 nanofiber membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The near-infrared photoresponsive electrospun PCL / MoS was prepared according to the following steps 2 Nanofiber Membrane:

[0035] S1. At room temperature, dissolve 0.4g of PCL in 5mL of hexafluoroisopropanol organic solution, place it on a magnetic stirrer and stir for 12 hours, ultrasonicate for half an hour, put the fully mixed solution into a syringe, and conduct electrospinning by electrospinning. Spinning (voltage 15kV, speed 0.8mL / h, distance 15cm)

[0036] S2. Combine PCL and PCL / MoS 2 The fiber membrane is cut into a disc with a diameter of about 1.6cm, and the reuse power density is 0.5W / cm 2 808nm near-infrared light irradiation to verify its photothermal conversion performance. Lighting conditions: light power 1W, light distance 5.6cm, light time 180s.

Embodiment 2

[0038] The near-infrared photoresponsive electrospun PCL / MoS was prepared according to the following steps 2 Nanofiber Membrane:

[0039] S1. At room temperature, add 0.05g MoS 2 Dissolve in 5mL hexafluoroisopropanol organic solution, place on a magnetic stirrer and stir for 6 hours, then add 0.4g PCL, stir for 12 hours, ultrasonic for half an hour, put the fully mixed solution into a syringe, and use electrospinning Electrospinning (voltage 15kV, speed 0.8mL / h, distance 15cm)

[0040] S2. Combine PCL and PCL / MoS 2 The fiber membrane is cut into a disc with a diameter of about 1.6cm, and the reuse power density is 0.5W / cm 2 808nm near-infrared light irradiation to verify its photothermal conversion performance. Lighting conditions: light power 1W, light distance 5.6cm, light time 180s.

Embodiment 3

[0042] The near-infrared photoresponsive electrospun PCL / MoS was prepared according to the following steps 2 Nanofiber Membrane:

[0043] S1. At room temperature, add 0.075g MoS 2 Dissolve in 5mL hexafluoroisopropanol organic solution, place on a magnetic stirrer and stir for 6 hours, then add 0.4g PCL, stir for 12 hours, ultrasonic for half an hour, put the fully mixed solution into a syringe, and use electrospinning Electrospinning (voltage 15kV, speed 0.8mL / h, distance 15cm)

[0044] S2. Combine PCL and PCL / MoS 2The fiber membrane is cut into a disc with a diameter of about 1.6cm, and the reuse power density is 0.5W / cm 2 808nm near-infrared light irradiation to verify its photothermal conversion performance. Lighting conditions: light power 1W, light distance 5.6cm, light time 180s.

[0045] attached by figure 1 It can be seen that electrospun PCL and PCL / MoS 2 The fiber structure of the fiber membrane under the electron microscope is uniform, and the fiber surface i...

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Abstract

The invention provides a near-infrared light response electrostatically spun polycaprolactone / molybdenum disulfide (PCL / MoS2) nanofiber membrane. The nanofiber membrane is composed of PCL and MoS2 and has a fiber web structure with high porosity, and the diameter of the fiber ranges from 150 nm to 350 nm. According to the invention, the PCL / MoS2 nanofiber membrane with photo-thermal performance is prepared by utilizing an electrostatic spinning technology, and the nanofiber membrane has good biocompatibility, mechanical performance and photo-thermal conversion performance, is expected to become a relatively ideal bone tissue engineering scaffold, and is expected to be applied to regeneration and repair of bone defects clinically.

Description

technical field [0001] The invention relates to a near-infrared photoresponsive electrospinning PCL / MoS 2 Nanofibrous membrane and method for its preparation. Background technique [0002] Bone tissue has a certain ability to regenerate and self-repair, and small-area bone defects can self-repair through the process of bone tissue self-absorption and reconstruction, but severe trauma, deformity, necrosis, tumor resection, cancer or congenital diseases can lead to bone defects An important reason for the large area of ​​bone defect caused by self-healing. At present, the main clinical repair methods include autologous / allogeneic bone, artificial material distraction osteogenesis, etc., but there are limitations such as insufficient bone source, co-infection, and immune response. Guided bone regeneration (GBR) is one of the effective methods for treating bone defects, and GBR membrane plays an important role in the treatment of bone defects. [0003] Electrospinning technol...

Claims

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Application Information

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IPC IPC(8): D04H1/728D04H1/435A61L27/02A61L27/18A61L27/50A61L27/56
CPCD04H1/728D04H1/435A61L27/50A61L27/025A61L27/18A61L27/56A61L2430/02A61L2400/12C08L67/04
Inventor 郑立赵劲民马可梁锐明廖传安苏伟
Owner GUANGXI MEDICAL UNIVERSITY
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