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Preparation method of multifunctional conjugated polymer gel-based composite

A conjugated polymer and composite material technology, which can be used in the fields of wave energy or particle radiation treatment materials, drug combinations, medical preparations with inactive ingredients, etc., which can solve the problems of high toxicity utilization efficiency and uneven distribution of photothermal materials. , to achieve the effect of making up for low utilization efficiency, simple process, and reducing the impact of damage

Active Publication Date: 2018-11-02
UNIV OF SHANGHAI FOR SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Aiming at the problems existing in the prior art, the present invention provides the preparation and application of a multifunctional conjugated high polymer gel-based composite material. The multifunctional sodium alginate hydrogel aims to solve the existing The problem of uneven distribution of photothermal materials in the tumor, strong toxicity and low utilization efficiency in the technology

Method used

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  • Preparation method of multifunctional conjugated polymer gel-based composite
  • Preparation method of multifunctional conjugated polymer gel-based composite
  • Preparation method of multifunctional conjugated polymer gel-based composite

Examples

Experimental program
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Embodiment 1

[0033] Dissolve 3 g of sodium alginate in 100 mL of deionized water, and stir evenly at room temperature to obtain an aqueous solution of sodium alginate. Then, take 1 mL of the above solution in a glass bottle (the glass bottle is placed in an ice-water bath). 32 μL of pyrrole and 56 μL of ferric chloride hexahydrate (concentration: 1 g / mL) were sequentially added into the glass bottle, and after 4 hours of reaction, the multifunctional conjugated high polymer gel-based composite material was obtained.

[0034] Preparation of drug-loaded composite hydrogel: Add 100 mg DOX to 100 mL deionized water, add 3 g sodium alginate after dissolving, and the rest of the steps are the same as above.

Embodiment 2

[0036] Dissolve 3 g of sodium alginate in 100 mL of deionized water, and stir evenly at room temperature to obtain an aqueous solution of sodium alginate. Then, take 1 mL of the above solution in a glass bottle (the glass bottle is placed in an ice-water bath). 56 μL of ferric chloride hexahydrate (concentration 1 g / mL) and 32 μL of pyrrole were added to the glass bottle in sequence, and after 4 hours of reaction, the multifunctional conjugated high polymer gel-based composite material was obtained.

[0037] Preparation of drug-loaded composite hydrogel: Add 100 mg DOX to 100 mL deionized water, add 3 g sodium alginate after dissolving, and the rest of the steps are the same as above.

Embodiment 3

[0039] The gel in Example 1 was freeze-dried, and its morphology was analyzed. Samples were analyzed on a FEI Magellan 400 field emission scanning electron microscope.

[0040] It can be seen from the scanning electron microscope pictures that figure 1 (a) The surface of sodium alginate gel is relatively smooth, figure 1 The polypyrrole in (b) is irregular spherical. And the composite hydrogel prepared with embodiment 1 and embodiment 2 ( figure 1 (c-d)) The morphology is consistent, that is, polypyrrole particles are distributed on the surface and inside of sodium alginate, which proves that polypyrrole and sodium alginate have been effectively compounded together.

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Abstract

The invention provides a preparation method of a multifunctional conjugated polymer gel-based composite. The method comprises the following steps: sodium alginate is dissolved in a solvent and stirredto be completely dissolved, mass percent concentration of dissolved sodium alginate is 0.5%-3%, and sodium alginate is placed in ice water bath for cooling; conjugated polymer monomers are dispersedin the sodium alginate solution, a mixed solution is obtained, and the conjugated polymer monomers are one of pyrrole, thiophene, aniline and dopamine; a metal cation compound is added to the mixed solution, the metal cation compound is one of ferric chloride hexahydrate and aluminium chloride, and the multifunctional conjugated polymer gel-based composite can be obtained after sufficient reaction. Drug supported conjugated polymer gel can be obtained by adding an anti-cancer drug to the sodium alginate solution. The prepared conjugated polymer gel-based composite has excellent photothermal conversion performance and good biocompatibility and can be applied to safe and efficient photothermal therapy of tumor.

Description

technical field [0001] The invention belongs to the field of biological nanomaterials, and relates to a gel compound, in particular to the preparation and application of a multifunctional conjugated high polymer and sodium alginate gel compound. Background technique [0002] Photothermal therapy is a new type of tumor treatment method. Its principle is to use near-infrared laser to irradiate the photothermal material enriched in the tumor site, and use the high heat generated by the photothermal conversion ability of the material to kill tumor cells. Near-infrared laser has the characteristics of strong penetration ability of biological tissue and small light attenuation, so it has become an important light source in the research of photothermal therapy. Polypyrrole (PPy) contains a conjugated structure and is a typical organic conductive polymer. In photothermal therapy, the photothermal conversion efficiency of photothermal materials is one of the key factors in the treat...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/06A61K47/36A61K31/704A61K31/4745A61P35/00
CPCA61K9/06A61K31/4745A61K31/704A61K41/0052A61K47/36A61P35/00
Inventor 王世革吴陈瑶赵九龙周春华邹多武吴环黄明贤
Owner UNIV OF SHANGHAI FOR SCI & TECH
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