Nano flower-like palladium-gold coated betulinic acid liposome and preparation method thereof

A technology of nano-liposome and betulinic acid, which is applied in the field of medicine, can solve the problem of killing tumor cells, etc., and achieve the effects of simple operation, good photothermal conversion performance and high repeatability
CN106620697AActive Publication Date: 2017-05-10YANSHAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
YANSHAN UNIV
Publication Date
2017-05-10

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Abstract

A nano flower-like palladium-gold coated betulinic acid liposome is a nano liposome formed by forming a nano flower-like palladium-gold alloy shell on the surface of a betulinic acid nano liposome, with the particle size of about 80-100 nm and the near infrared absorption wavelength of 500-900 nm. A preparation method mainly comprises steps as follows: palladium nanoparticles are obtained by reducing a palladium chloride solution with ascorbic acid, the palladium nanoparticles and the betulinic acid nano liposome modified with glutathione are subjected to shaded incubation under the mild condition, then a gold chloride solution and a hydroxylamine hydrochloride solution are added, and shaded incubation is performed for 4-9 h. The preparation method is simple to operate, easy to control and high in repeatability; the prepared nano flower-like palladium-gold coated betulinic acid liposome has good photo-thermal conversion performance, makes medicine release controllable, is more effective and low-toxic and can combine photo-thermal therapy and chemotherapy to treat cancer collaboratively.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, in particular to a nano liposome and a preparation method thereof. Background technique

[0002] Cancer is one of the major malignant diseases that currently threaten human health. The traditional chemotherapy drugs currently used have serious side effects, and the emergence of nanotechnology provides new ideas for the treatment of cancer. Among them, liposome is a non-toxic, biocompatible and promising nano-drug delivery system. However, in order to achieve a better therapeutic effect, conventional liposomes still have some defects, such as instability, poor targeting, and uncontrollable drug release.

[0003] In recent years, various photothermal materials have been gradually applied in the field of biomedicine. Among them, nanomaterials that respond to near-infrared light are the most widely studied, such as noble metal nanomaterials (gold nanomaterials), graphene, carbon nanotubes, and rar...

Claims

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