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Application of Tripterygium in the Preparation of Drugs for Treating Complicated Refractory Depression

A triptolide, refractory technology is applied in the field of pharmaceutical use in the preparation of drugs for the treatment of complex refractory depression, and can solve the problem of increasing depression, anxiety and suicidal tendencies, failing to relieve bipolar depression, and increasing insulin sensitivity. and other problems, to achieve the effects of low preparation cost, improved compliance, and reduced economic burden

Active Publication Date: 2021-11-19
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Similarly, obesity itself has been proven to have an inhibitory effect on the efficacy of antidepressants, and many types of obesity treatment drugs have also been withdrawn from the market or warned by the FDA to use with caution because of the increased risk of depression
The weight loss preparation, Rimonabant, an endocannabinoid type 1 receptor antagonist, which was launched in 2008, has a good effect on weight loss, increasing insulin sensitivity and improving lipid metabolism disorders. side effects of tendencies forced out of the market
Therefore, based on the fact that tripterine inhibits the activity of DDP-IV, people in the industry cannot make an inference that it helps relieve bipolar depression

Method used

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  • Application of Tripterygium in the Preparation of Drugs for Treating Complicated Refractory Depression
  • Application of Tripterygium in the Preparation of Drugs for Treating Complicated Refractory Depression
  • Application of Tripterygium in the Preparation of Drugs for Treating Complicated Refractory Depression

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0035] Experimental example 1: The effect of tripterine on depression in the classic model of metabolic syndrome (Diets Induced Obesity, DIO) mice

[0036] 1. Experimental animals

[0037] SPF grade 8-week-old adult male C57 / BL6 mice, weighing 24-26g, were provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., and the animal certificate number is SYXK-2019-0003.

[0038] 2. Experimental grouping

[0039] After adapting to the environment for 4 days, the mice were weighed, and the forced swimming test and tail suspension test were carried out to exclude those whose body weight was less than 23 grams, the stay time in the center field of the open field test was less than 15 seconds, and the immobility time in the forced swimming test exceeded 160 seconds. Seconds, or individuals whose immobility time was detected by tail suspension for 50-100 seconds, and then randomly divided into groups, that is, common feed group, high-fat feed group, and tripteryglide h...

experiment example 2

[0064] Experimental example 2: The effect of tripterine on depression in classical neuropathic pain (Spinal cord Ligation, SNL) model mice

[0065] 1. Experimental animals

[0066] SPF grade 8-week-old adult male C57 / BL6 mice, weighing 24-26g, provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., animal certificate number SYXK-2019-0002.

[0067] 2. Experimental grouping

[0068] After adapting to the environment for 4 days, the mice were weighed, and the open field test, forced swimming test and tail suspension test were carried out, and the body weight was less than 23 grams. 160 seconds, or individuals whose immobility time is beyond 50-100 seconds by tail suspension, and then randomly divided into sham operation group, SNL model group, and tripterygium low-middle-high group, each parallel experiment Each group is more than 8.

[0069] 3. Establishment method of mouse neuropathic pain model

[0070] The present application adopts the method of spin...

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Abstract

The application relates to the application of tripterine in the preparation of medicines for treating complex refractory depression. Complex refractory depression is a refractory chronic mental disorder, so far there is no safe and effective clinical intervention. Tripterygium has the characteristics of low toxicity and high safety. This application discloses for the first time that tripterygne has definite and significant curative effect on treating complex depression complicated by major chronic diseases such as neuropathic pain and metabolic syndrome.

Description

technical field [0001] The application relates to a new pharmaceutical application of tripterine, especially the pharmaceutical application in the preparation of drugs for the treatment of complex refractory depression. Background technique [0002] Depression is a kind of refractory mental illness involving many complex factors such as genetics, environment, psychology, and physiology. Currently, depression affects about 322 million people worldwide. In my country, the prevalence of depression is about 4.2%, and as a common complication or risk factor of major diseases such as neuropathic pain, metabolic syndrome (including diabetes), cardiovascular and cerebrovascular diseases, and cancer, it seriously affects the physical and mental health of the people , is a major mental illness that causes disability and poverty in our country. The design of first-line antidepressants mainly targets the reuptake of neurotransmitters such as serotonin and acetylcholine and the activity...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/56A61K36/37A61P25/24A61P3/04A61P3/10
CPCA61K31/56A61K36/37A61P3/04A61P3/10A61P25/24
Inventor 朱春燕杨俊吴红艳林娜
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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