Applications of tripterine in preparation of drugs for treating complex refractory depression

A tripterine, refractory technology, applied in the field of pharmaceutical use in the preparation of drugs for the treatment of complex refractory depression, can solve the problem of increasing depression, anxiety and suicidal tendencies, unable to relieve bidirectional depression, and increasing insulin sensitivity and other issues, to achieve the effect of expanding medicinal use, low preparation cost, and improving compliance

Active Publication Date: 2021-02-02
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Similarly, obesity itself has been proven to have an inhibitory effect on the efficacy of antidepressants, and many types of obesity treatment drugs have also been withdrawn from the market or warned by the FDA to use with caution because of the increased risk of depression
The weight loss preparation, Rimonabant, an endocannabinoid type 1 receptor antagonist, which was launched in 2008, has a good effect on weight loss, increasing insulin sensitivity and improving lipid metabolism disorders. side effects of tendencies forced out of the market
Therefore, based on the fact that tripterine inhibits the activity of DDP-IV, people in the industry cannot make an inference that it helps relieve bipolar depression

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Applications of tripterine in preparation of drugs for treating complex refractory depression
  • Applications of tripterine in preparation of drugs for treating complex refractory depression
  • Applications of tripterine in preparation of drugs for treating complex refractory depression

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0035] Experimental example 1: The effect of tripterine on depression in the classic model of metabolic syndrome (Diets Induced Obesity, DIO) mice

[0036] 1. Experimental animals

[0037] SPF grade 8-week-old adult male C57 / BL6 mice, weighing 24-26g, were provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., and the animal certificate number is SYXK-2019-0003.

[0038] 2. Experimental grouping

[0039] After adapting to the environment for 4 days, the mice were weighed, and the forced swimming test and tail suspension test were carried out to exclude those whose body weight was less than 23 grams, the stay time in the center field of the open field test was less than 15 seconds, and the immobility time in the forced swimming test exceeded 160 seconds. Seconds, or individuals whose immobility time was detected by tail suspension for 50-100 seconds, and then randomly divided into groups, that is, common feed group, high-fat feed group, and tripteryglide h...

experiment example 2

[0064] Experimental example 2: The effect of tripterine on depression in classical neuropathic pain (Spinal cord Ligation, SNL) model mice

[0065] 1. Experimental animals

[0066] SPF grade 8-week-old adult male C57 / BL6 mice, weighing 24-26g, provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., animal certificate number SYXK-2019-0002.

[0067] 2. Experimental grouping

[0068] After adapting to the environment for 4 days, the mice were weighed, and the open field test, forced swimming test and tail suspension test were carried out, and the body weight was less than 23 grams, the dwell time in the center field of the open field test was less than 15 seconds, and the forced swimming time was more than 10 seconds. 160 seconds, or individuals whose immobility time is beyond 50-100 seconds by tail suspension, and then randomly divided into groups, that is, sham operation group, SNL model group, and tripterygium low-middle-high group, in each parallel exper...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to applications of tripterine in preparation of drugs for treating complex refractory depression. The complex refractory depression is a refractory chronic mental disorder, and up to now, the lack of safe and effective clinical intervention still troubles people. The tripterine has the characteristics of being low in toxicity and high in safety. The invention firstly discloses that the tripterine has the precise and significant efficacy of treating complex depression complicated by major chronic diseases such as neuropathic pain and metabolic syndromes.

Description

technical field [0001] The application relates to a new pharmaceutical application of tripterine, especially the pharmaceutical application in the preparation of drugs for the treatment of complex refractory depression. Background technique [0002] Depression is a kind of refractory mental illness involving many complex factors such as genetics, environment, psychology, and physiology. Currently, depression affects about 322 million people worldwide. In my country, the prevalence of depression is about 4.2%, and as a common complication or risk factor of major diseases such as neuropathic pain, metabolic syndrome (including diabetes), cardiovascular and cerebrovascular diseases, and cancer, it seriously affects the physical and mental health of the people , is a major mental illness that causes disability and poverty in our country. The design of first-line antidepressants mainly targets the reuptake of neurotransmitters such as serotonin and acetylcholine and the activity...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61K36/37A61P25/24A61P3/04A61P3/10
CPCA61K31/56A61K36/37A61P3/04A61P3/10A61P25/24
Inventor 朱春燕杨俊吴红艳林娜
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap