The invention relates to an improved preparation technique for Ceftriaxone Sodium, which comprises: with nitrogen protection, in solvent, reacting between 7-ACT and AE-active ester with amine as intermediate; adding benzothiazole as assisting solvent and sodium salt agent, separating and crystallizing to obtain the product. Wherein, the reaction solvent comprises halogenated hydrocarbon of alkane, acetic ester or acetone and alcohol and water; stirring the 7-ACT and AE-active ester till clear, adding assisting solvent of benzothiazole and salt agent; extracting, degerming, filtering, adding insoluble solvent for Ceftriaxone Sodium; when liquid shows turbid, feeding crystal; separating the crystal by insoluble solvent to cefotaxime sodium; cleaning, drying treatment to obtain the product for injection. This invention needs just one-step operation, has good crystallization and short production period, improves product yield, and decreases solvent harm to operation crews.