9 results about "Cefotaxime Sodium" patented technology

The invention relates to the field of cephalosporin drugs, and particularly discloses a cefotaxime sodium synthesis process which comprises the following steps: mixing cefotaxime sodium, purified water and isopropanol, adding activated carbon, filtering for the first time, then adding dichloromethane, isopropanol and cefotaxime sodium seed crystals, waiting for the solution to separate out crystals, and finally filtering. According to the scheme, research is carried out aiming at the problem of yield fluctuation in industrial production of the cefotaxime sodium, and three key factors, namely the salt-forming agent proportion, the reaction temperature and the solvating-out agent isopropanol (dosage), which have the most obvious influence on the quality of the cefotaxime sodium are selected for optimization. Through response surface method research, a reasonable process parameter range is defined, the yield of the cefotaxime sodium is stably increased and maintained at 91.30%, and a scientific and reliable basis is provided for process adjustment in subsequent industrial production.

The present application provides a method for refining cefotaxime sodium, belonging to the technical field of pharmaceutical preparations. The crude cefotaxime hydrochloride is dissolved in a mixed solvent, the pH is adjusted to 2-4, a desalting agent is added for salting out, followed by decolorization, filtration, and the filtrate is retained. The mixed solvent is acetone + alcohol, acetone + alkane, or acetone + alcohol + alkane. The salifying agent is dissolved in the mixed solvent, and the resulting solution is dropped into the filtrate for salting, crystallization, filtration, washing, draining, and vacuum drying to obtain the finished product cefotaxime sodium. Applying the present application to the preparation of cefotaxime sodium not only reduces the impurity content of the product but also helps to reduce the acetone residue, with good product color and high yield.

The invention relates to the technical field of drug detection, and discloses a method for detecting beta-lactam compound residues in a terbinafine hydrochloride bulk drug, which effectively corrects the matrix effect of terbinafine hydrochloride on a target object by adopting a matrix target method. According to the present invention, with the combination of the optimized pretreatment steps (the ratio of the diluent to the phosphate buffer), the chromatographic conditions and the mass spectrum parameters, the simultaneous quantitative detection of the eight beta-lactam compounds (cefoxitin sodium TBXD, cefotaxime sodium TBSW, cefminox sodium TBMN, cefmetazole acid TBMZ, meropenem MEP, imipenem IMP, ertapenem sodium ERP and biapenem BIP) is achieved, the quantification limit is as low as 0.008 ppm, and the detection sensitivity is high; the detection sensitivity and accuracy are remarkably improved, and the technical problem that the trace beta-lactam cross contamination in the terbinafine hydrochloride raw material medicine cannot be reliably monitored in the prior art is solved.

The invention discloses a salmonella bacteriophage and antibiotic combined medication mode with a synergistic effect. The bacteriophage is salmonella bacteriophage SP4, and the antibiotic is cefotaxime sodium. The two bactericidal drugs are used for treating the chicken salmonellosis, and a model is established to verify the combination effect. Compared with an attacking control group, the application mode of the combination of the bacteriophage and the cefotaxime sodium disclosed by the invention can remarkably improve the growth performance of chickens and obviously reduce the content and death rate of salmonella in chicken manure, is a novel and creative application mode, can be used as a novel application strategy for treating chicken salmonellosis, and has a wide application prospect. Good market application values are realized.

The application discloses a long-acting and stable drug-releasing cefotaxime sodium preparation and a preparation method and application thereof, relates to the technical field of drug synthesis, and the cefotaxime sodium preparation comprises cefotaxime sodium tablet crystals, and a slow-release carrier is coated outside the cefotaxime sodium tablet crystals; the slow-release carrier has a three-level structure, comprising a phospholipid coating layer coated on the surface of the cefotaxime sodium tablet crystals, a mesoporous silica shell layer coated on the surface of the phospholipid coating layer, and a temperature-sensitive hydrogel network layer coated on the surface of the mesoporous silica shell layer. The cefotaxime sodium preparation has the properties of rapid effect, super-long-acting and stable drug-releasing and high stability, and the preparation process flow is simple, and the control condition is mild.

The invention discloses a preparation method of cefotaxime sodium, which belongs to the technical field of chemical synthesis, and comprises the following steps: taking a first solvent as a reaction solvent, adding 2, 6-diaminopyridine, taking a methanol solution of sodium acetate as a salt-forming agent solution, and carrying out acid-base neutralization reaction with cefotaxime acid to generate a cefotaxime sodium reaction solution; enabling the cefotaxime sodium reaction liquid to pass through a membrane to obtain filtrate, dripping the filtrate into a second solvent, and performing crystallization, crystal growing, suction filtration and drying to obtain the cefotaxime sodium. The process method provided by the invention is good in economical efficiency, the yield and the purity can be improved, and the dried cefotaxime sodium product is low in impurity and high in medication safety.

The invention belongs to the technical field of chemical synthesis, and discloses a cefotaxime sodium synthesis method based on one-step salification of a mixed solvent system and sodium isooctanoate. The method comprises the following steps: by taking 7-aminocephalosporanic acid (7-ACA) and 2-(2-aminothiazole-4-yl)-2-(methoxyimino) acetoxyimino ethyl acetate (AE active ester) as raw materials, in a dichloromethane-methanol mixed solvent, completing a condensation reaction through triethylamine catalysis, directly dropwise adding a sodium isooctanoate acetone solution to realize salification in one step, and carrying out post-treatment to obtain the 7-aminocephalosporanic acid (7-ACA)-2-(methoxyimino) acetoxyimino ethyl acetate (AE active ester)-2-(methoxyimino) acetoxyimino ethyl acetate (AE active ester). The cefotaxime acid intermediate does not need to be separated; and performing low-temperature washing and accurate drying subsequently to obtain a cefotaxime sodium finished product. According to the method, the defects that in the prior art, a two-step method needs intermediate separation and a one-pot method needs alkaline degradation are overcome, the production period is shortened to be smaller than or equal to 8 h, the total yield is larger than or equal to 92%, the HPLC purity is larger than or equal to 99.6%, the wastewater COD is smaller than or equal to 2000 mg / L, solvent residues meet the ICH Q3C standard, and the method has the advantages of industrial feasibility and environmental protection.

The invention provides a method for recovering cefotaxime acid from a cefotaxime sodium mother solution, which comprises the following steps: concentrating the cefotaxime sodium mother solution to obtain a concentrated mother solution; adjusting the pH value of the concentrated mother liquor by using acid, and then mixing the concentrated mother liquor and water in a microporous mixer to obtain a mixed liquor; standing the mixed solution, separating to obtain a water phase, adding a decolorizing agent or a filter aid into the water phase, stirring, and filtering to obtain filtrate; washing the decolorizing agent and the filter aid with water, and merging into the filtrate; adding the filtrate and acid into a dispersing agent at the same time, and separating out crystals; and adjusting the pH value for growing crystals, filtering after growing the crystals to obtain crystals, washing and drying to obtain the cefotaxime acid product. According to the method, the concentrated mother liquor and the water are mixed through the microporous mixer, cefotaxime in the concentrated mother liquor can be effectively extracted, the recovery rate of cefotaxime acid is increased, the crystallization method that filtrate and acid are added into the dispersing agent at the same time is adopted, post-treatment of crystallization liquid is facilitated, the obtained product is high in quality, and the quality requirement of enterprises is met.

This invention relates to the field of biomedical technology, and in particular to the application of TarA inhibitors in the preparation of antibacterial potentiators for enhancing the efficacy of β-lactam antibiotics against methicillin-resistant Staphylococcus aureus (MRSA) infections. Through virtual screening, target validation, and in vitro and in vivo pharmacodynamic experiments, this invention confirms that the natural product norzelamin is an effective TarA inhibitor and antibacterial potentiator. Experiments show that norzelamin has a synergistic effect when used in combination with various β-lactam antibiotics. In a mouse model of MRSA-infected pneumonia, the combination of norzelamin and cefotaxime sodium significantly reduced pulmonary bacterial load, alleviated systemic inflammatory response, and improved lung tissue pathological damage compared to monotherapy. This invention provides a novel synergistic treatment strategy and candidate compound for overcoming MRSA resistance in clinical practice, and has significant development value and application prospects.