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Cefonicid sodium composition powder for injection

A technology of cefnixime sodium and its composition, which is applied in the field of medicine and medicine manufacturing, can solve the problems of low bioavailability and poor curative effect, and achieve the effect of eliminating active effect and improving antibacterial activity

Inactive Publication Date: 2014-01-29
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is aimed at the cefnixime antibacterial drug containing a single component, which is insensitive to Gram-negative bacteria Escherichia coli and Gram-positive bacteria Tetradococcus, the defects of poor curative effect, and the problem that the bioavailability is not high Provide a cefnixime sodium antibacterial pharmaceutical composition with wider antibacterial spectrum, stronger antibacterial effect and bioavailability and its pharmaceutical preparation

Method used

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  • Cefonicid sodium composition powder for injection

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1, the preparation of the freeze-dried powder injection of the composition of cefnixin sodium for injection, in 1000 pieces.

[0034] Prescription:

[0035] Cefdonix Sodium 80g

[0036] Chitosan Nanoparticles 56g

[0037] Water for injection 2000ml

[0038] 2. Preparation process:

[0039] The chitosan nanoparticle that takes by weighing 56g is slowly added in the water for injection of 2000ml, stirs while adding to dissolve.

[0040] Add 80 g of Cefnixime Sodium and stir to dissolve until clear.

[0041] Adjust the pH to 5.1 with buffer salts of sodium dihydrogen phosphate and disodium hydrogen phosphate, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, and filter the liquid through 0.45 μm and 0.22 μm microporous membranes to detect the content of intermediates , according to the calculation of the filling volume of 80 mg per bottle of cefnixime sodium.

[0042] Fill according to the test requirements, put it into a ...

Embodiment 2

[0043] Embodiment 2, the preparation of the freeze-dried powder injection of the cefnixin sodium composition for injection, in 1000 pieces.

[0044] 1. Prescription:

[0045] Cefdonix Sodium 80g

[0046] Chitosan Nanoparticles 68g

[0047] Water for injection 2000ml

[0048] 2. Preparation process:

[0049] The chitosan nanoparticle that takes by weighing 68g is slowly added in the water for injection of 2000ml, stirs while adding to dissolve.

[0050] Add 80 g of Cefnixime Sodium and stir to dissolve until clear.

[0051] Adjust the pH to 5.1 with buffer salts of sodium dihydrogen phosphate and disodium hydrogen phosphate, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, and filter the liquid through 0.45 μm and 0.22 μm microporous membranes to detect the content of intermediates , according to the calculation of the filling volume of 80 mg per bottle of cefnixime sodium.

[0052] Fill according to the test requirements, put it into a ...

Embodiment 3

[0053] Embodiment 3, the preparation of the freeze-dried powder injection of the composition of cefnixin sodium for injection, in 1000 pieces.

[0054] Prescription:

[0055] Cefdonix Sodium 80g

[0056] Chitosan Nanoparticles 47g

[0057] Water for injection 2000ml

[0058] 2. Preparation process:

[0059] The chitosan nanoparticle that takes by weighing 47g is slowly added in the water for injection of 2000ml, stirs while adding to dissolve.

[0060] Add 80 g of Cefnixime Sodium and stir to dissolve until clear.

[0061] Adjust the pH to 5.1 with buffer salts of sodium dihydrogen phosphate and disodium hydrogen phosphate, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, and filter the liquid through 0.45 μm and 0.22 μm microporous membranes to detect the content of intermediates , according to the calculation of the filling volume of 80 mg per bottle of cefnixime sodium.

[0062]Fill according to the test requirements, put it into a f...

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Abstract

The invention provides a cefonicid sodium composition powder for injection, and belongs to the field of medicine and medicine preparation technology. The cefonicid sodium composition powder comprises following raw material ingredients, by weight, 7.26 to 9.17 parts of cefonicid sodium, 5.16 to 6.50 parts of chitosan nanoparticle, and 82.38 to 88.10 parts of injection water. dvantages of the cefonicid sodium composition powder are that: 1) antibacterial effect of the cefonicid sodium composition on Gram-negative escherichia coli and Gram-positive micrococcus tetragenus is increased significantly; 2) the chitosan nanoparticle is capable of passing through tissue spaces, staying in tissues and cells for a long period of time, and releasing medicines; and after intravenous injection, the chitosan nanoparticle is mainly gathered in organs with abundant mononuclear macrophages, especially in liver and bone marrow; 3) improvement of activity is capable of shortening medication cycle of patients, and reducing occurrence likelihood of adverse reaction caused by accumulation of cefonicid sodium; and 4) the chitosan nanoparticle can be used as a freeze-dried skeleton agent of the freeze-dried powder injection instead of mannitol, so that active effects of mannitol on human bodies are avoided.

Description

Technical field: [0001] The invention relates to the technical field of medicine and medicine manufacture, in particular to a freeze-dried powder injection of a cefnixime sodium composition for injection. Background technique: [0002] Cefnixime sodium is a semi-synthetic third-generation cephalosporin, which has strong antibacterial activity against most Gram-positive and negative bacteria. Enterobacter aerogenes, Proteus, Diplococcus and Staphylococcus aureus, etc. [0003] Cefnixime Sodium for Injection has fast action and is commonly used in clinical practice. However, the safety range is small, the effective plasma range is narrow, the therapeutic index is narrow, there are many factors affecting its pharmacokinetics, and the elimination rate in the body varies greatly among individuals, so it is difficult to master the clinical dosage. [0004] The drug resistance caused by the abuse of drugs has brought new problems to the prevention and treatment of bacterial infec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/546A61K47/36A61K31/722A61P31/04
CPCY02A50/30
Inventor 汪六一汪金灿张庆庆
Owner HAINAN WEI KANG PHARMA QIANSHAN
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