Rhizoma paridis yunnanensis total-saponin enteric-coated sustained release preparation for treating liver injury, and preparation method for enteric-coated sustained release preparation

A technology of total saponins and polyphylla, which is applied in the field of biomedicine, can solve the problems of no liver damage, achieve the effects of avoiding nausea, shortening the medication cycle, and changing the absorption process and state

Pending Publication Date: 2019-12-06
XISHUANGBANNA TROPICAL BOTANICAL GARDEN CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the treatment of liver injury by traditional Chinese medicine Zhonglou

Method used

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  • Rhizoma paridis yunnanensis total-saponin enteric-coated sustained release preparation for treating liver injury, and preparation method for enteric-coated sustained release preparation
  • Rhizoma paridis yunnanensis total-saponin enteric-coated sustained release preparation for treating liver injury, and preparation method for enteric-coated sustained release preparation
  • Rhizoma paridis yunnanensis total-saponin enteric-coated sustained release preparation for treating liver injury, and preparation method for enteric-coated sustained release preparation

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0019] (1) The preparation method of sustained-release tablet or sustained-release granule comprises the following steps: the sustained-release material is blended into other excipients of molding as the skeleton of sustained-release and prepared according to the corresponding granulation process; Granulated into granules or further compressed into tablets, and then coated with enteric-coated materials on the prepared sustained-release granules or compressed sustained-release tablets to obtain enteric-coated sustained-release tablets or enteric-coated sustained-release granules;

[0020] (2) The preparation method of the sustained-release enteric-coated capsule comprises the steps of: blending the sustained-release material as a sustained-release skeleton into other excipients for molding according to the corresponding granulation process, drying after granulation, and sizing into granules, Fill it into enteric-coated capsules.

[0021] In the present invention, in order to ad...

Embodiment 1

[0031] Enteric-coated sustained-release tablets, the ingredients are:

[0032]

[0033]

[0034] Make 1000 enteric-coated sustained-release tablets. The preparation method is as follows: pass sodium sulfite, hydroxypropyl methylcellulose, starch, microcrystalline cellulose and magnesium stearate through 80 mesh sieves respectively for later use, weigh hydroxypropyl methylcellulose, starch, micro After the crystalline cellulose is placed in a mixer and mixed evenly, it is then mixed with the above-mentioned amount of total saponin dry powder of Dianaphyllum polyphylla and polyene phosphatidylcholine by the method of equal increase, and an appropriate amount of 4% polyvinylpyrrolidone and 75% ethanol solution is added. After granulation and sizing, dry at 60°C, add the above-mentioned amount of magnesium stearate to the dry granules and mix them evenly, pass through a 16-mesh sieve for granulation with a swinging granulator, measure the content of the granules, and determi...

Embodiment 2

[0036] Enteric-coated sustained-release capsules, the ingredients are:

[0037]

[0038] Made into 1000 enteric-coated sustained-release capsules. The preparation method is: pass sodium sulfite, hydroxypropyl methylcellulose, ethyl cellulose, lactose and magnesium stearate through 80-mesh sieve respectively, weigh hydroxypropyl methylcellulose, ethyl cellulose, Lactose and magnesium stearate were placed in a mixer and mixed evenly, and then mixed with the above-mentioned amount of total saponins dry powder and polyene phosphatidylcholine in equal increments, and an appropriate amount of 4% polyvinylpyrrolidone and 85% Ethanol solution to make soft materials, and granulate in a granulator. The granules prepared above were dried at 60°C. Then pass through a swinging granulator, and use a 20-mesh sieve to sieve the granules. The content of the mixed granules is determined, and the volume range of the enteric-coated capsule shell is determined to be filled. After passing the...

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Abstract

The invention relates an enteric-coated sustained release preparation which takes rhizoma paridis yunnanensis total saponins and polyene phosphatidyl choline as active ingredients, and is mainly usedfor preventing and treating liver injury diseases. The sustained release oral solid preparation is prepared from the rhizoma paridis yunnanensis total saponins, the polyene phosphatidyl choline and pharmaceutically acceptable auxiliary materials, wherein the rhizoma paridis yunnanensis total saponins and the polyene phosphatidyl choline are medicinal active ingredients. The composition is dissolved in intestinal tracts and delays a medicine releasing speed, the influence of a gastric acid on the active ingredients of the rhizoma paridis yunnanensis total saponins and the polyene phosphatidyl choline is avoided, a situation that gastric mucosa is irritated due to long-term medicine taking is avoided, and adverse reactions, including nausea, emesis, bellyache, diarrhea and the like, caused by taking medicines can be reduced. The composition can synergistically and effectively perform the curative effect of the medicine, is obviously superior to an effect obtained when the same dosage ofrhizoma paridis yunnanensis total saponins or polyene phosphatidyl choline is singly used, and has the characteristics that a treatment effect is enhanced, the taking frequency of the medicine is reduced, medicine utilization compliance is improved, the cytotoxicity of the rhizoma paridis yunnanensis total saponins is lowered and the like.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to an enteric-coated slow-release preparation of total saponins of Diana polyphylla for treating liver damage and a preparation method thereof. Background technique [0002] The liver has various physiological functions such as secretion, excretion, synthesis, biotransformation and immunity, and is an important human organ. Viruses, drugs, alcohol, etc. can all cause liver cell damage, and severe liver damage can lead to liver failure. Liver injury is a common pathological state of many liver diseases, and its long-term existence is often the most important initiating factor leading to liver fibrosis, even liver cirrhosis and liver cancer. my country is a big country with hepatitis B. About 25%-40% of chronic hepatitis B patients in China will eventually die of liver cirrhosis or liver cancer. Drug-induced liver disease refers to the functional and structural damage of the l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K31/685A61K9/52A61K9/22A61P1/16
CPCA61K9/1652A61K9/2054A61K9/2059A61K31/685A61K36/896A61P1/16A61K2300/00
Inventor 刘长宁李菁胡翔马菊莲
Owner XISHUANGBANNA TROPICAL BOTANICAL GARDEN CHINESE ACAD OF SCI
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