New medicinal preparation for vagina
A preparation and vaginal technology, applied in the field of vaginal in-situ gel preparations, can solve the problems of easy loss, adverse reactions, unevenness, etc., and achieve the effects of increasing bioadsorption and weakening mobility
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Embodiment 1
[0043] Example 1: In situ gel formulations containing nifesamide.
[0044] Take nifesamide 0.00025%, 21% poloxamer 407, 10% poloxamer 188, sterile phosphate buffer solution (pH3.5-pH5) to the full amount. Nifesamide is dissolved in water, and the poloxamer is slowly added to the above solution under the conditions of ice bath and stirring, and stored under low temperature refrigeration until a clear solution is formed. The preparation has the functions of contraception and prevention of pathogenic microorganism infection.
Embodiment 2
[0045] Example 2: In situ gel formulations containing hyaluronic acid and nifesamide.
[0046] Take nifesamide 0.00025%, sodium hyaluronate 0.2%, 21% poloxamer 407, 10% poloxamer 188, sterile phosphate buffer solution (pH3.5-pH5) to the full amount. Sodium hyaluronate was dissolved in the buffer solution, and then the in-situ gel preparation was prepared according to the process of Example 1. The preparation has the functions of contraception and prevention of pathogenic microorganism infection.
Embodiment 3
[0047] Example 3: In situ vaginal gel preparation containing carbomer and acyclovir for women.
[0048] Take acyclovir 2%, benzalkonium chloride 0.02%, carbomer 934P 0.2%, mannitol 5%, 22% poloxamer 407, 10% poloxamer 188, sterile water to the full amount. Disperse carbomer in water, adjust the pH to 3.5~pH5 with sodium hydroxide solution, add drugs, benzalkonium chloride and mannitol, slowly add poloxamer to the above solution under ice bath and stirring conditions, and refrigerate at low temperature Store until a clear solution is formed.
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Abstract
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Application Information
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