69 results about "Polyene phosphatidylcholine" patented technology

Polyenylphosphatidylcholine is topically applied to treat skin damage, such as contact dermatitis (particularly diaper area dermatitis), atopic dermatitis, xerosis, eczema (including severe hand and foot eczema), rosacea, seborrhea, psoriasis, thermal and radiation burns, other types of skin inflammation, and aging. Typical compositions contain from about 0.25% to about 10% of a polyenylphosphatidylcholine preparation obtained form natural sources such as soybean oil which contains at least about 25% by weight, preferably about 40% or more, dilinoeoylphosphatidylcholine.

The present invention discloses one kind of freeze dried polyene phosphatidylcholine powder for injection and its preparation process. It features that the preparation contains polyene phosphatidylcholine and solubilizer sodium deoxycholate, sodium dehydrocholate or sodium cholate in the weight ratio of 0.5-1.5.

The present invention relates to soft polyene phosphatidylcholine capsule and its preparation process, and belongs to the field of medicine preparing technology. The preparation process include mixing polyene phosphatidylcholine in the recipe amount, vitamins and co-solvent, antioxidant under medicine GMP condition; adding supplementary material and mixing; sieving, subpacking, sealing, scrubbing capsule and air drying to obtain soft capsule. Encapsulating polyene phosphatidylcholine, which is easy to oxidize, sensitive to light and heat and unstable in water solution, can raise the stability of the medicine and reduce the stimulation to gastrointestinal tract.

The invention discloses a polyene phosphatidyl choline freeze dried injection for the treatment of hepatic diseases, which comprises polyene phosphatidyl choline as the main ingredients and pharmaceutically acceptable carrying agents, wherein the carrying agent can be auxiliary solvent selected from sodium cholate, sodium deoxycholate, sodium deoxycholate, hydroxypropyl-beta-cyclodextrin, hydroxyethyl-beta-cyclodextrin and/or methyl cyclodextrin. The injection has higher stability.

The invention discloses a method for preparing polyene phosphatidyl choline injection, including mixing polyene phosphatidyl choline, solubilizer, and injection water in proportion, stirring them into a colloidal dispersive system, adding in activated carbon to absorb, and adding proper antiseptic. It is a low-cost, simple-technique preparing method.

The invention relates to a phosphatidyl choline freeze powder injection and relative preparation, wherein said formula is formed by phosphatidyl choline, solubilizer, support agent and other additive components; the phosphatidyl choline content is 10-60%; the solubilizer can colalin, glycocholic acid, cholaic acid, deoxycholic acid, anthrodsoxycholic acid, or taurodeoxycholic acid and relative salt, loxapine and tween; the support agent can be freeze protector. The invention has high stability, which can be stored for 1 year at normal temperature, without allergic and excitation.

The present invention relates to a polyene phosphatidylcholine freeze-dried powder injection. It is formed from polyene phosphatidylcholine as effective medicinal component and auxiliary component including necessary solubiliser and freeze-drying protective agent. Its weight composition includes 0.1-1.5 portions of polyene phosphatidylcholine, the weight ratio of solubilizer and polyene phosphatidylcholine is 0.1-2.5:1 and the weight ratio of freeze-drying protective agent and polyene phosphatidylcholine is 0.1-10:1. According to the requirement the pharmaceutically-acceptable vitamin as other auxiliary component also can be added.

The invention relates to a freeze-dried powder injection of polyene phosphatidyl choline and its preparation, which comprises charging into a finite amount of water for injection by auxiliary solvent, pH regulator, polyene phosphatidyl choline, anti-oxidant agent, homogenizing through stirring, adjusting pH to 7.0-10.0, charging right amount of excipient, auxiliary solvent, and water for injection, charging activated charcoal and vitamins to obtain intermediate products, filtering with filter membrane and split charging.

The present invention discloses freeze dried polyene phosphatidylchline preparation for injection and its preparation process. The freeze dried polyene phosphatidylchline preparation contains polyene phosphatidylchline in 30-60 wt% and medicinal supplementary material 40-70 wt%. The test on stability shows that the preparation of the present invention has excellent stability and high storage temperature up to 25deg.c. The present invention has simple and practical preparation process and stable and reliable product.

The invention relates to a compound of phosphatide bilineurine powder injection and relative preparation. Wherein, the inventive product can avoid benzenemethanol, to be stably used. And its components contain phosphatide bilineurine, cholate and support agent. The invention uses special method and treatment. The inventive product via frozen and dried is made into white or yellow powder injection, which can be diluted before vein injection.

The present invention relates to medicine technology, and is especially one kind of complex glycyrrhizinate and its preparation process. The complex glycyrrhizinate has the liver protecting effects of glycyrrhizic acid or glycyrrhizinate and essential phospholipids combined together, and thus hepatosis treating effect higher than that of each of glycyrrhizic acid or glycyrrhizinate and essential phospholipids.

The invention relates to a polyene phosphatidylcholine capsule and a preparation method thereof, and belongs to the field of medicine preparations. Polyene phosphatidylcholine has unstable characteristic, different-degree phosphatide hydrolysis is generated during long-term storage of polyene phosphatidylcholine, and leads to content reduction of polyene phosphatidylcholine and generation increase of a toxic substance lysophosphatidylcholine. The invention provides the polyene phosphatidylcholine capsule which comprises polyene phosphatidylcholine and medium-chain triglyceride, and is substantially improved in stability compared with a current marked product Essentiale N. The polyene phosphatidylcholine capsule also comprises one or more pharmaceutically accepted excipient. Additionally, the invention also aims at providing a method for preparing the polyene phosphatidylcholine capsule, and the method is simple in preparation technology and is convenient for industrialized production.

The invention provides a polyene phosphatidyl choline composition for injection and a preparation method thereof. The composition is composed of methoxy polyethylene glycol-phosphatidyl ethanolamine, cholesterol, water for injection, soybean oil, a glycine-HCl buffer solution, and is prepared through a compound compatibility method. The polyene phosphatidyl choline composition has the advantages of reduced safety hazard and improved drug effect.

The invention relates to a polyene phosphatidyl choline intravenous preparation (comprising infusion and freeze-drying) and a preparation method thereof. The raw materials of the polyene phosphatidyl choline intravenous preparation comprise polyene phosphatidyl choline, sodium cholate and xylitol which can accept the adjustment osmotic pressure. The process comprises the following steps: preparing a colloidal dispersion system from the polyene phosphatidyl choline and the sodium cholate according to the prescription under the conditions required by the process; carrying out active carbon decoloration on the colloidal dispersion system, then carrying out rough filtration on the obtained product under the condition of adding nitrogen, adding the xylitol according to the prescription into the obtained solution to prepare concentrated solution for later use; and adding water for injection to make up to volume, and preparing the infusion by the processing procedures of filtering, filling, adding the stopper, pressing the cover, sterilizing, detecting leakage and the like, or preparing the freeze-drying preparation by the processing procedures of filtering, filling, freeze-drying, adding the stopper, pressing the cover and sterilizing. The prepared infusion solution finished product has convenient clinical use, better stability on low temperature storage or clinical use, no turbidity or emulsification phenomenon, and better safety performance.

The invention relates to an oral solid preparation containing polyene phosphatidyl choline and a preparation method thereof. The preparation method comprises the following steps: dissolving polyene phosphatidyl choline in ethanol; adequately mixing the polyene phosphatidyl choline with a matrix, an antioxygen and a sorbefacient in a protective state; carrying out vacuum drying and volatilizing to remove ethanol, and preparing pellets by a pill dropping machine; and packaging the pellets coated or packing in hard capsules or tabletting and coating to obtain the oral solid preparation containing polyene phosphatidyl choline. The oral solid preparation containing polyene phosphatidyl choline provided by the invention can enhance the stability of polyene phosphatidyl choline, reduce the gastrointestinal irritation by the medicine and improve the dissolving-out performance of polyene phosphatidyl choline, so that the equipment cost is saved to the benefit of industrialized production.

The present invention belongs to the field of pharmaceutical preparations, and mainly relates to a polyene phosphatidyl choline capsule and a preparation process thereof, wherein the polyene phosphatidyl choline capsule contains polyene phosphatidyl choline and soybean oil, and can further contain other pharmaceutically acceptable excipients. Compared to the polyene phosphatidyl choline capsule in the prior art, the polyene phosphatidyl choline capsule of the present invention has good stability so as to well ensure the medication safety and the medication efficacy, and polyene phosphatidyl choline capsule is produced by using the liquid filling hard capsule technology so as to provide advantages of simple production process, small equipment occupation area, low cost, high automation degree, less impurity, and the like.

Disclosed is a traditional Chinese medicine effective component compound for preventing and treating fatty liver. The traditional Chinese medicine effective component compound is characterized in comprising salidroside, gypenosides, curcumin and bighead atractylodes rhizome polysaccharide, wherein the ratio of each component is 4-10 parts of salidroside, 15-20 parts of gypenosides, 3-8 parts of curcumin and 65-75 parts of bighead atractylodes rhizome polysaccharide. Dosage forms of the traditional Chinese medicine effective component compound for preventing and treating fatty liver comprise tablets, capsules, pills, oral liquid or suspensions. The traditional Chinese medicine effective component compound for preventing and treating fatty liver in the invention is safe and effective, has definite active substances, and has more significant effect on preventing and treating fatty liver compared with a component compound containing a single component and Western medicine of polyene phosphatidylcholine capsule.