Polyene phosphatidyl choline lyophilized powdered injection

A technology of polyene phosphatidylcholine and freeze-dried powder injection, which is applied in the direction of freeze-drying transportation, powder transportation, digestive system, etc., and can solve the problem that polyene phosphatidylcholine is not easy to form, and there is no preparation of polyene phosphatidylcholine jelly Dry powder injection and other issues

Inactive Publication Date: 2006-04-26
GUANGDONG XIANQIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Freeze-dried powder injection can avoid the use of stabilizers, but it is not easy to form when polyene phosphatidylcholine i

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The polyene phosphatidylcholine freeze-dried powder injection was prepared according to the following formula.

[0026] Specific formula:

[0027] Polyene Phosphatidylcholine 250g

[0028] Sodium deoxycholate 500g

[0029] Water for injection 2000ml

[0030] A total of 1000 bottles of freeze-dried products were produced

[0031] Specific steps are as follows:

[0032] Preparation of liquid medicine:

[0033] Weigh polyene phosphatidylcholine and sodium deoxycholate according to the prescription, add 2000ml of water for injection, fully stir to dissolve;

[0034] Depyrogenation and sterilization:

[0035] Add 0.1% (W / V) activated carbon for injection to the above solution, stir thoroughly for 20 to 30 minutes, and filter to sterilize with a 0.22 μm microporous membrane;

[0036] Filling:

[0037] (1) Treatment of controlled vials: select 10ml controlled vials, roughly wash with water during pretreatment, then finely wash with purified water, then finely wash with...

Embodiment 2

[0043] The polyene phosphatidylcholine frozen powder injection was prepared according to the following formula.

[0044] Specific formula:

[0045] Polyene Phosphatidylcholine 232.5g

[0046] Sodium deoxycholate 500g

[0047] Water for injection 2000ml

[0048] A total of 1000 bottles of freeze-dried products were produced

[0049] Specific steps are as follows:

[0050] Preparation of liquid medicine:

[0051] Weigh polyene phosphatidylcholine and sodium deoxycholate according to the prescription, add 2000ml of water for injection, fully stir to dissolve;

[0052] Depyrogenation and sterilization:

[0053] Add 0.1% (W / V) activated carbon for injection to the above solution, stir thoroughly for 20 to 30 minutes, and filter to sterilize with a 0.22 μm microporous membrane;

[0054] Filling:

[0055](1) Treatment of controlled vials: select 10ml controlled vials, roughly wash with water during pretreatment, then finely wash with purified water, then finely wash with wate...

Embodiment 3

[0061] The polyene phosphatidylcholine freeze-dried powder injection was prepared according to the following formula.

[0062] Specific formula:

[0063] Polyene Phosphatidylcholine 120g

[0064] Sodium cholate 250g

[0065] Water for injection 1500ml

[0066] A total of 1000 bottles of freeze-dried products were produced

[0067] Specific steps are as follows:

[0068] Preparation of liquid medicine:

[0069] Weigh polyene phosphatidylcholine and sodium cholate according to the prescription, add 1500ml of water for injection, fully stir to dissolve;

[0070] Depyrogenation and sterilization:

[0071] Add 0.1% (W / V) activated carbon for injection to the above solution, stir thoroughly for 20 to 30 minutes, and filter to sterilize with a 0.22 μm microporous membrane;

[0072] Filling:

[0073] (1) Treatment of controlled vials: select 7ml controlled vials, roughly wash with water during pretreatment, then finely wash with purified water, then finely wash with water for ...

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PUM

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Abstract

The invention discloses a polyene phosphatidyl choline freeze dried injection for the treatment of hepatic diseases, which comprises polyene phosphatidyl choline as the main ingredients and pharmaceutically acceptable carrying agents, wherein the carrying agent can be auxiliary solvent selected from sodium cholate, sodium deoxycholate, sodium deoxycholate, hydroxypropyl-beta-cyclodextrin, hydroxyethyl-beta-cyclodextrin and/or methyl cyclodextrin. The injection has higher stability.

Description

technical field [0001] The invention relates to a liver-protecting drug and its preparation, more specifically, the invention relates to a polyene phosphatidylcholine freeze-dried powder injection and a preparation method thereof. Background technique [0002] In recent years, the incidence of fatty liver and acute and chronic hepatitis has been on the rise, and its incidence has reached about 10% of the total population. Fatty liver and acute and chronic hepatitis can lead to liver fibrosis if not treated in time, and can even develop into liver cirrhosis. Clinically, polyene phosphatidylcholine preparations, as a good liver-protecting drug, have achieved good results in the treatment of fatty liver and acute and chronic hepatitis. [0003] Polyene phosphatidylcholine is composed of one molecule of phosphoric acid, two molecules of unsaturated fatty acid and choline. It is a natural choline phosphodiglyceride with excess unsaturated fatty acid, which can protect liver sinu...

Claims

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Application Information

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IPC IPC(8): A61K31/6615A61K9/19A61P1/16
Inventor 刘春平康秋萍李绍安李云霞
Owner GUANGDONG XIANQIANG PHARMA
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