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Glycyrrhizic acid double salt and preparation thereof

A technology of glycyrrhizinate and glycyrrhizic acid, applied in the field of pharmaceutical preparations and medicines, to prevent liver cell necrosis, prevent fibrosis, and improve liver function

Active Publication Date: 2007-12-05
CHIA TAI TIANQING PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no public report on the formation of double salts between glycyrrhizic acid (including extracts and their acid salts) and polyene phosphatidylcholine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Weigh 20g of 18α diammonium glycyrrhizinate and 20g of polyene phosphatidylcholine, pass through nitrogen protection, add 200ml of tetrahydrofuran, stir at 40°C until a clear solution is formed, and evaporate to dryness under reduced pressure to obtain a light yellow solid, namely glycyrrhizic acid double salt.

Embodiment 2

[0031] Weigh 10g of 18β disodium glycyrrhizinate and 50g of polyene phosphatidylcholine, pass through nitrogen protection, add 600ml of tetrahydrofuran, stir at room temperature (20°C) until a clear solution is formed, and evaporate to dryness under reduced pressure to obtain a light yellow solid that is licorice acid double salt.

Embodiment 3

[0033] Weigh 25g of magnesium salt of 18α glycyrrhizinate and 50g of polyene phosphatidylcholine, pass through nitrogen protection, add 250ml of absolute ethanol and 75ml of water, heat, stir and reflux at 60°C until a clear solution is formed, and evaporate to dryness under reduced pressure to obtain The light yellow solid is glycyrrhizic acid double salt.

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PUM

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Abstract

The present invention relates to medicine technology, and is especially one kind of complex glycyrrhizinate and its preparation process. The complex glycyrrhizinate has the liver protecting effects of glycyrrhizic acid or glycyrrhizinate and essential phospholipids combined together, and thus hepatosis treating effect higher than that of each of glycyrrhizic acid or glycyrrhizinate and essential phospholipids.

Description

Technical field: [0001] The invention relates to the technical field of medicines and pharmaceutical preparations, in particular to a double salt of glycyrrhizic acid, its preparation and a preparation method. Background technique: [0002] Glycyrrhizic acid is the main active ingredient in the natural plant medicine licorice. It consists of a molecule of glycyrrhetinic acid (belonging to pharmacologically active molecules) and two molecules of glucuronic acid. It exists in the form of two epimers, 18α and 18β. Natural products The vast majority of glycyrrhizic acid are 18β body. A number of studies on glycyrrhizic acid preparations by scholars at home and abroad have shown that glycyrrhizic acid preparations have strong anti-inflammatory, anti-virus, liver cell protection, and reduce alanine aminotransferase (ALT), aspartate aminotransferase ( AST) and serum bilirubin. Recent studies have shown that it also has obvious anti-fibrosis, anti-oxidation and anti-apoptosis effe...

Claims

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Application Information

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IPC IPC(8): C07J63/00A61K31/704A61P1/16
Inventor 程艳菊张来芳张喜全
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
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