Preparation method for high-purity polyene phosphatidylcholine
A polyene phosphatidylcholine, high-purity technology, applied in the field of pharmacy, can solve problems such as unfavorable industrial production, large solvent consumption and loss, environmental pollution, etc. The effect of prolonged concentration time
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Embodiment 1
[0034] Preparation of polyene phosphatidylcholine with purity greater than 90%
[0035] Add methanol (500ml) to a 1L three-necked round-bottomed reaction flask, replace with vacuum nitrogen three times, under nitrogen protection, add soybean lecithin powder (100g) with a purity of 50%, stir to dissolve, add 200-300 mesh neutral alumina (200g ), at a temperature of 20-30°C, stirring and adsorbing for 2 hours, suction filtration with diatomaceous earth, rinsing the filter cake with 100ml of methanol, collecting the filtrate, and completing the adsorption once.
[0036] Add the filtrate into a 1L three-necked round-bottomed reaction flask again, and replace it with nitrogen three times under vacuum. Under the protection of nitrogen, add 200-300 mesh neutral alumina (200g), control the temperature at 20-30°C, stir and adsorb for 2 hours, and pad with diatoms Soil suction filtration, 100ml methanol rinses the filter cake, collects the filtrate, and completes the secondary adsorptio...
Embodiment 2
[0040] Preparation of polyene phosphatidylcholine with purity greater than 95%
[0041] The pale yellow waxy solid obtained after concentration in Example 1 was dissolved in 150ml of mixed solvent (the volume ratio of dichloromethane and methanol was 5:1), replaced by vacuum nitrogen three times, and under the protection of nitrogen, 200-300 mesh silica gel (76g ), at a temperature of 20-30°C, stir and adsorb for 2 hours, filter with diatomaceous earth, rinse the filter cake with 38ml of mixed solvent (the volume ratio of dichloromethane and methanol is 5:1), collect the filtrate, and complete the adsorption once .
[0042] Add the filtrate to a 250ml three-necked round-bottomed reaction flask again, and replace it with nitrogen three times under vacuum. Under the protection of nitrogen, add 200-300 mesh silica gel (76g), control the temperature at 20-30°C, stir and adsorb for 2 hours, and filter with diatomaceous earth , 38ml of mixed solvent (dichloromethane and methanol vo...
Embodiment 3
[0045] Preparation of polyene phosphatidylcholine with purity greater than 90%
[0046] Add methanol (500ml) to a 1L three-necked round-bottomed reaction flask, replace with vacuum nitrogen three times, under nitrogen protection, add soybean lecithin powder (100g), stir to dissolve, add 200-300 mesh neutral alumina (300g), and control the temperature Stir and adsorb for 2 hours at 20-30°C, filter with diatomaceous earth, rinse the filter cake with 100ml of methanol, collect the filtrate, and complete the first adsorption.
[0047] Add the filtrate into a 1L three-necked round-bottomed reaction flask again, and replace it with nitrogen three times under vacuum. Under the protection of nitrogen, add 200-300 mesh neutral alumina (300g), control the temperature at 20-30°C, stir and adsorb for 2 hours, and pad with diatoms Soil suction filtration, rinse the filter cake with 100ml of methanol, collect the filtrate, and under the protection of nitrogen, concentrate under reduced pres...
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