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Preparation method for high-purity polyene phosphatidylcholine

A polyene phosphatidylcholine, high-purity technology, applied in the field of pharmacy, can solve problems such as unfavorable industrial production, large solvent consumption and loss, environmental pollution, etc. The effect of prolonged concentration time

Active Publication Date: 2018-06-01
YANGTZE RIVER PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, how to improve the purity of PC has restricted the application of PC
The amount and loss of solvent in the solvent extraction method are too large, and the toxicity will pollute the environment; although the inorganic salt precipitation method can improve the purity of PC, it will lead to an increase in the residual amount of inorganic salt in the product; although supercritical technology has green and pollution-free And the advantages of high product purity, but the equipment cost is too high, power consumption is large, which is not conducive to industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Preparation of polyene phosphatidylcholine with purity greater than 90%

[0035] Add methanol (500ml) to a 1L three-necked round-bottomed reaction flask, replace with vacuum nitrogen three times, under nitrogen protection, add soybean lecithin powder (100g) with a purity of 50%, stir to dissolve, add 200-300 mesh neutral alumina (200g ), at a temperature of 20-30°C, stirring and adsorbing for 2 hours, suction filtration with diatomaceous earth, rinsing the filter cake with 100ml of methanol, collecting the filtrate, and completing the adsorption once.

[0036] Add the filtrate into a 1L three-necked round-bottomed reaction flask again, and replace it with nitrogen three times under vacuum. Under the protection of nitrogen, add 200-300 mesh neutral alumina (200g), control the temperature at 20-30°C, stir and adsorb for 2 hours, and pad with diatoms Soil suction filtration, 100ml methanol rinses the filter cake, collects the filtrate, and completes the secondary adsorptio...

Embodiment 2

[0040] Preparation of polyene phosphatidylcholine with purity greater than 95%

[0041] The pale yellow waxy solid obtained after concentration in Example 1 was dissolved in 150ml of mixed solvent (the volume ratio of dichloromethane and methanol was 5:1), replaced by vacuum nitrogen three times, and under the protection of nitrogen, 200-300 mesh silica gel (76g ), at a temperature of 20-30°C, stir and adsorb for 2 hours, filter with diatomaceous earth, rinse the filter cake with 38ml of mixed solvent (the volume ratio of dichloromethane and methanol is 5:1), collect the filtrate, and complete the adsorption once .

[0042] Add the filtrate to a 250ml three-necked round-bottomed reaction flask again, and replace it with nitrogen three times under vacuum. Under the protection of nitrogen, add 200-300 mesh silica gel (76g), control the temperature at 20-30°C, stir and adsorb for 2 hours, and filter with diatomaceous earth , 38ml of mixed solvent (dichloromethane and methanol vo...

Embodiment 3

[0045] Preparation of polyene phosphatidylcholine with purity greater than 90%

[0046] Add methanol (500ml) to a 1L three-necked round-bottomed reaction flask, replace with vacuum nitrogen three times, under nitrogen protection, add soybean lecithin powder (100g), stir to dissolve, add 200-300 mesh neutral alumina (300g), and control the temperature Stir and adsorb for 2 hours at 20-30°C, filter with diatomaceous earth, rinse the filter cake with 100ml of methanol, collect the filtrate, and complete the first adsorption.

[0047] Add the filtrate into a 1L three-necked round-bottomed reaction flask again, and replace it with nitrogen three times under vacuum. Under the protection of nitrogen, add 200-300 mesh neutral alumina (300g), control the temperature at 20-30°C, stir and adsorb for 2 hours, and pad with diatoms Soil suction filtration, rinse the filter cake with 100ml of methanol, collect the filtrate, and under the protection of nitrogen, concentrate under reduced pres...

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Abstract

The invention discloses a preparation method for high-purity polyene phosphatidylcholine. According to the method, high-purity polyene phosphatidylcholine is prepared by subjecting soyabean lecithin powder to adsorption by neutral alumina and silica gel respectively. Polyene phosphatidylcholine prepared by using the method is low in peroxide value and high in purity; the preparation method is simple in process operation and beneficial for industrial production; and the purity and the content of polyene phosphatidylcholine can reach 98% or more and 95% or more, respectively, and all the relatedsubstances are qualified.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a method for preparing high-purity polyene phosphatidylcholine, wherein the polyene phosphatidylcholine can be used for auxiliary treatment of liver diseases. Background technique [0002] Natural phospholipids are the basic components of animal and plant cell membranes, nuclear membranes, and plastid membranes, and are the material basis of living organisms. Soybean phospholipids contain phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI) and phosphatidic acid (PA) and other components, of which phosphatidylcholine, also known as lecithin, is a Phosphoric acid lipids have special physiological activity, and have lipophilic fatty acyl non-polar ends, hydrophilic phospholipid ester groups, and choline-based polar ends. It is a surfactant with superior performance. Widely used in food, cosmetics, medicine and other fields. [0003] Natural phosph...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/10
CPCC07F9/103
Inventor 周崴海徐浩宇蔡伟阴启明李鹏飞韩冬黄淑萍郝秀斌刘景龙刘晶
Owner YANGTZE RIVER PHARM GRP CO LTD
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