Polyvinyl-phosphorylcholine elaioplast preparation and its making method

A technology of polyene phosphatidylcholine and liposome preparations, which is applied in the directions of liposome delivery, pharmaceutical formulations, active ingredients of phosphorus compounds, etc. Permeability, hepatocyte protection, and regenerative effects

Inactive Publication Date: 2007-01-17
裴泽军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the user population is limited, and the needs of clinical use cannot be met.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The process steps of the preparation method of the liposome preparation for treating various types of liver diseases of the present invention are as follows: its formula composition: in g / ml:

[0027] The present invention weighs 50g of polyene phosphatidylcholine, 70g of refined lecithin, and puts 20g of cholesterol in a round-bottomed flask, adds about 350ml of absolute ethanol to the above-mentioned mixture to completely dissolve into a clear solution, and puts it in a constant temperature water bath with a temperature of 60°C. Rotate and dry for 0.5-10 hours to form a film, then carry out vacuum drying for 4 hours, rotation speed: 30-100 rpm, vacuum drying temperature: 20-60°C, vacuum degree 0.08-0.095Mpa; plus adjust the pH value The stabilizer is aspartic acid 3g, gelatin 30g; vitamin 28g (vitamin B1 3mg: vitamin B2 3mg: vitamin B6 3mg: vitamin B12 100ug: vitamin E acetate 33mg: vitamin C 100mg ratio of multivitamins); mannitol 50g 1000ml solution to dissolve the ...

Embodiment 2

[0029] The process steps of the preparation method of the liposome preparation for treating various types of liver diseases of the present invention are as follows: its formula composition: in g / ml:

[0030] The present invention weighs 30g of polyene phosphatidylcholine, 60g of refined lecithin, and puts 10g of cholesterol in a round-bottomed flask, adds about 250ml of ether to the above-mentioned mixture to completely dissolve into a clear solution, puts it in a constant temperature water bath temperature: 55°C, and spin-dries 0.5-10 hours to form a film, then carry out vacuum drying treatment for 4 hours, rotation speed: 30-100 rpm, vacuum drying temperature: 20-60°C, vacuum degree: 0.08-0.095Mpa; Cystine 2.5g, gelatin 40g; vitamin 15g (vitamin B1 3mg: vitamin B2 3mg: vitamin B6 3mg: vitamin B12 100ug: vitamin C 100mg ratio multivitamins); glucose 50g solution 1000ml dissolved film, pH value: 3~10 ;Sonicate with an ultrasonic instrument for 20 minutes to 2 hours, and then u...

Embodiment 3

[0032] The process steps of the preparation method of the liposome preparation for treating various types of liver diseases of the present invention are as follows: its formula composition: in g / ml:

[0033]The present invention weighs 50g of polyene phosphatidylcholine, 80g of refined soybean lecithin, and 15g of cholesterol in a round-bottomed flask, adds about 400ml of chloroform to the above mixture to completely dissolve into a clear solution, and puts it in a constant temperature water bath. 0.5-10 hours to form a film, and then carry out vacuum drying treatment for 4 hours, rotation speed: 30-100 rpm, vacuum drying temperature: 20-60°C, vacuum degree 0.08-0.095Mpa; Amino acid 5g, gelatin 20g, vitamin 20g (vitamin E acetate 33mg: the compound vitamin of vitamin C 100mg ratio); Mannitol 50g solution 1000ml dissolving film, pH value: 3~10; Carry out homogenization 30 with high-pressure homogenization pump Minutes to 5 hours, homogenate pump speed: 500-10000 rpm, to make th...

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Abstract

A polyene phosphatidylcholine liposome with high curative effect is prepared through dissolving polyene phosphatifylcholine, phosphatide and cholesterol in organic solvent, constant-temp drying for removing solvent, filming, adding vitamin, stabilizer and mannitol or glucose solution, dissolving, ultrasonic vibration or homogenizing, filtering by membrane for removing bacteria, loading in containers, filling N2 or H2 and sealing.

Description

technical field [0001] The invention relates to a polyene phosphatidylcholine liposome preparation and a preparation method thereof, which are used for bile obstruction; poisoning; prevention of recurrence of gallstones; pregnancy poisoning; treatment of psoriasis, neurodermatitis, radiation syndrome and other diseases , belongs to the technical field of medicine preparation. Background technique [0002] At present, there are more than 3,500 patients with various liver diseases in my country, hundreds of millions of hepatitis virus carriers, and hundreds of thousands of people die from liver diseases every year. The task of prevention and treatment of liver disease is very arduous. At present, there are many kinds of drugs for preventing and treating liver diseases, but there are few drugs with good curative effect and low side effects, especially the broad-spectrum drugs that are effective for various liver diseases. The main component of polyene phosphatidylcholine for ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/66A61K31/714A61P1/16A61P17/00A61P15/00
Inventor 裴泽军孙欣丁永娟
Owner 裴泽军
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