Polyvinyl-phosphorylcholine elaioplast preparation and its making method
A technology of polyene phosphatidylcholine and liposome preparations, which is applied in the directions of liposome delivery, pharmaceutical formulations, active ingredients of phosphorus compounds, etc. Permeability, hepatocyte protection, and regenerative effects
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Embodiment 1
[0026] The process steps of the preparation method of the liposome preparation for treating various types of liver diseases of the present invention are as follows: its formula composition: in g / ml:
[0027] The present invention weighs 50g of polyene phosphatidylcholine, 70g of refined lecithin, and puts 20g of cholesterol in a round-bottomed flask, adds about 350ml of absolute ethanol to the above-mentioned mixture to completely dissolve into a clear solution, and puts it in a constant temperature water bath with a temperature of 60°C. Rotate and dry for 0.5-10 hours to form a film, then carry out vacuum drying for 4 hours, rotation speed: 30-100 rpm, vacuum drying temperature: 20-60°C, vacuum degree 0.08-0.095Mpa; plus adjust the pH value The stabilizer is aspartic acid 3g, gelatin 30g; vitamin 28g (vitamin B1 3mg: vitamin B2 3mg: vitamin B6 3mg: vitamin B12 100ug: vitamin E acetate 33mg: vitamin C 100mg ratio of multivitamins); mannitol 50g 1000ml solution to dissolve the ...
Embodiment 2
[0029] The process steps of the preparation method of the liposome preparation for treating various types of liver diseases of the present invention are as follows: its formula composition: in g / ml:
[0030] The present invention weighs 30g of polyene phosphatidylcholine, 60g of refined lecithin, and puts 10g of cholesterol in a round-bottomed flask, adds about 250ml of ether to the above-mentioned mixture to completely dissolve into a clear solution, puts it in a constant temperature water bath temperature: 55°C, and spin-dries 0.5-10 hours to form a film, then carry out vacuum drying treatment for 4 hours, rotation speed: 30-100 rpm, vacuum drying temperature: 20-60°C, vacuum degree: 0.08-0.095Mpa; Cystine 2.5g, gelatin 40g; vitamin 15g (vitamin B1 3mg: vitamin B2 3mg: vitamin B6 3mg: vitamin B12 100ug: vitamin C 100mg ratio multivitamins); glucose 50g solution 1000ml dissolved film, pH value: 3~10 ;Sonicate with an ultrasonic instrument for 20 minutes to 2 hours, and then u...
Embodiment 3
[0032] The process steps of the preparation method of the liposome preparation for treating various types of liver diseases of the present invention are as follows: its formula composition: in g / ml:
[0033]The present invention weighs 50g of polyene phosphatidylcholine, 80g of refined soybean lecithin, and 15g of cholesterol in a round-bottomed flask, adds about 400ml of chloroform to the above mixture to completely dissolve into a clear solution, and puts it in a constant temperature water bath. 0.5-10 hours to form a film, and then carry out vacuum drying treatment for 4 hours, rotation speed: 30-100 rpm, vacuum drying temperature: 20-60°C, vacuum degree 0.08-0.095Mpa; Amino acid 5g, gelatin 20g, vitamin 20g (vitamin E acetate 33mg: the compound vitamin of vitamin C 100mg ratio); Mannitol 50g solution 1000ml dissolving film, pH value: 3~10; Carry out homogenization 30 with high-pressure homogenization pump Minutes to 5 hours, homogenate pump speed: 500-10000 rpm, to make th...
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