Polyene phosphatidyl choline injection and method for preparing the same

A technology of polyene phosphatidylcholine and injection, which is applied in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the problems of poor stability, poor clarity, and the need for nitrogen. protection and other issues to achieve the effect of reducing the risk of medication, increasing stability and improving safety
CN101152189AActive Publication Date: 2008-04-02SICHUAN HAISCO PHARMA CO LTD +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SICHUAN HAISCO PHARMA CO LTD
Publication Date
2008-04-02
Patent Text Reader

Abstract

The invention discloses a polyene phosphatidyl choline injection and the preparation method. The components and the ratio (portion) of the polyene phosphatidyl choline injection of the invention is: 465 portion of polyene phosphatidyl choline injection, 88 portion of benzyl zlcohol, 50 to 800 portion of glycocholic acid, cholic acid or tween-80, 50 to 80 portion of alcohol, propanediol or glycerin, 15 to 200 portion of sodium hydroxide or sodium carbonate, 0.5 to 5 portion of 2,6-D-itert-butyl-p-cresol, 0.8 to 8 portion of Tertiary butyl-4-hydroxyl anisole, 3 to 25 portion of Vitamin E by weight. The polyene phosphatidyl choline injection of the invention has good clarity, high stability, simple preparation process and easy operation.
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Description

technical field

[0001] The invention relates to a polyene phosphatidylcholine injection and a preparation method thereof. Background technique

[0002] Polyene phosphatidylcholine is a liver cell membrane protector, which has the functions of protecting liver sinusoidal endothelium and liver cell biofilm from damage, repairing membrane damage, promoting membrane regeneration, etc., and can reduce fatty infiltration and inflammatory response of liver cells, increase RNA and protein synthesis and glycogen content to promote liver cell regeneration, reduce the formation of connective tissue by inhibiting collagen production, reducing the ratio of collagen / DNA and liver hydroxyproline production, so as to achieve the treatment of acute and chronic hepatitis, liver cirrhosis, poisoning Metabolic liver disease, hepatic steatosis caused by various reasons, hepatic coma, secondary liver dysfunction and other liver diseases.

[0003] Polyene phosphatidylcholine is insoluble in water...

Claims

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