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Polyene phosphatidyl choline composition for injection and preparation method thereof

A technology for polyene phosphatidylcholine and injection, which is applied in the directions of drug combinations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. and other problems, to achieve the effect of exact curative effect and good safety

Inactive Publication Date: 2014-05-28
HAISCO PHARMA GRP INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2% benzyl alcohol is mainly to reduce the pain during injection, but the injection site often produces induration and irritating pain after injection, indicating that the adverse reactions of 2% benzyl alcohol combined with penicillin are more harmful to the human body, and there is a phenomenon of superposition

Method used

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  • Polyene phosphatidyl choline composition for injection and preparation method thereof
  • Polyene phosphatidyl choline composition for injection and preparation method thereof
  • Polyene phosphatidyl choline composition for injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026]

[0027] Add polyene phosphatidylcholine to water for injection, add methoxypolyethylene glycol-phosphatidylethanolamine and cholesterol to soybean oil, and dissolve at room temperature. After the dissolution, mix the above two liquids and add antioxidant vitamin E, and probe for ultrasound Form colostrum, put it in a closed container, and rotate it under reduced pressure at room temperature until it forms a colloidal state, then add another glycine-HCl buffer solution into the closed container, continue to evaporate under reduced pressure for 1.5 hours, and form a uniform emulsion. , use the peristaltic pump to transport the prepared emulsion to the installed microporous membrane filter with a pore size of 0.22 μm for sterilization and filtration, and the initial filtrate is immediately returned to the original liquid tank. After the clarity inspection is qualified, The medicinal solution is received in a serum bottle that has been sterilized by autoclaving; after th...

Embodiment 2

[0029]

[0030]

[0031] Add polyene phosphatidylcholine to water for injection, add methoxypolyethylene glycol-phosphatidylethanolamine and cholesterol to soybean oil, and dissolve at room temperature. After the dissolution, mix the above two liquids and add antioxidant vitamin E, and probe for ultrasound Form colostrum, put it in a closed container, and rotate it under reduced pressure at room temperature until it forms a colloidal state, then add another glycine-HCl buffer solution into the closed container, continue to evaporate under reduced pressure for 1 hour, and form a uniform emulsion. , use the peristaltic pump to transport the prepared emulsion to the installed microporous membrane filter with a pore size of 0.45 μm for sterilization and filtration, and the initial filtrate is immediately returned to the stock solution barrel. After the clarity inspection is qualified, The medicinal solution is received in a serum bottle that has been sterilized by autoclaving...

Embodiment 3

[0033]

[0034]

[0035] Add polyene phosphatidylcholine to water for injection, add methoxypolyethylene glycol-phosphatidylethanolamine and cholesterol to soybean oil, dissolve at room temperature, after the dissolution, mix the above two liquids, add antioxidant vitamin C, and probe for ultrasound Form colostrum, put it in a closed container, and rotate it under reduced pressure at room temperature until it forms a colloidal state, then add another glycine-HCl buffer solution into the closed container, continue to evaporate under reduced pressure for 1.5 hours, and form a uniform emulsion. , use the peristaltic pump to transport the prepared emulsion to the installed microporous membrane filter with a pore size of 0.22 μm for sterilization and filtration, and the initial filtrate is immediately returned to the original liquid tank. After the clarity inspection is qualified, The medicinal solution is received in a serum bottle that has been sterilized by autoclaving; aft...

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Abstract

The invention provides a polyene phosphatidyl choline composition for injection and a preparation method thereof. The composition is composed of methoxy polyethylene glycol-phosphatidyl ethanolamine, cholesterol, water for injection, soybean oil, a glycine-HCl buffer solution, and is prepared through a compound compatibility method. The polyene phosphatidyl choline composition has the advantages of reduced safety hazard and improved drug effect.

Description

technical field [0001] The invention relates to a composition for polyene phosphatidylcholine injection and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique [0002] When suffering from liver disease, the metabolic activity of the liver is severely impaired. Polyene Phosphatidylcholines provide high-dose, readily available high-energy polyene phosphatidylcholines that are chemically identical to important endogenous phospholipids. Phospholipids are necessary for the synthesis of lipoproteins by the liver to transport lipids from hepatocytes to peripheral storage. Lack of phospholipids can easily lead to fatty liver due to blocked lipoprotein synthesis. [0003] Polyene phosphatidylcholine mainly enters into liver cells, and combines with liver cell membranes and organelle membranes as a complete molecule, and can be secreted into bile. Therefore, polyene phosphatidylcholine has the following physiological functions:...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/685A61K47/18A61K47/04A61P1/16
Inventor 郑伟
Owner HAISCO PHARMA GRP INC
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