New Application of Xiaochaihu Granules Combined with Antibiotics

A technology of Xiaobupleurum granules and antibiotics, which is applied in the direction of medical preparations containing active ingredients, antibacterial drugs, plant/algae/fungus/moss components, etc., can solve problems that have not been reported and researched, and achieve good synergistic growth Efficacy, the effect of good clinical effect

Active Publication Date: 2021-12-17
GUANGZHOU BAIYUSN GUANGHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no reports or studies on the inhibitory effect of Xiaochaihu granules on MRSA and its synergistic sensitization to anti-MRSA antibiotics

Method used

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  • New Application of Xiaochaihu Granules Combined with Antibiotics
  • New Application of Xiaochaihu Granules Combined with Antibiotics
  • New Application of Xiaochaihu Granules Combined with Antibiotics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The present invention is carried out experiment by adopting test tube double dilution method, measures the minimum inhibitory concentration (MIC) of Xiaobupleurum granule medicinal liquid and four kinds of antibiotics to MRSA, adopts the MIC of each combined medicine to measure again by checkerboard method, investigates the effect of Xiaobupleurum granule solution on MRSA. Sensitization of erythromycin, ceftriaxone sodium, and levofloxacin against MRSA.

[0037] The following combined with specific experiments will further explain the effect of Xiaochaihu granules on inhibiting MRSA sensitization in combination with antibiotics.

[0038] 1. Experimental strains

[0039] MRSA standard strains: ATCC33591 and ATCC43300 were purchased from Shanghai Guyan Industrial Co., Ltd.

[0040] 2. Drug grouping and preparation

[0041] Because sucrose as an excipient can lead to false positive results in antibacterial tests, Xiao Bupleurum granules (sugar-free) were used in follow-u...

Embodiment 2

[0063] The present invention adopts MRSA-infected pneumonia mouse model to carry out experiments to investigate the regulating effect of Xiaochaihu granules combined with erythromycin on the immune and inflammatory response of MRSA-infected mice, and finally finds that Xiaochaihu granules can sensitize erythromycin against MRSA effect.

[0064] Combined with specific experiments, the sensitization effect of Xiaochaihu granules on combined antibiotics to inhibit MRSA will be further explained below.

[0065] 1. Experimental animals

[0066] 90 SPF-grade ICR male mice, weighing 13-15 g, were provided by the Guangdong Provincial Medical Experimental Animal Center, with the certificate number SYXK (Guangdong) 2019-0185. Start the experiment one week after the experimental animals adapt to the new environment, and take appropriate measures to reduce the damage to the animals during the experiment.

[0067] 2. Experimental strains

[0068] MRSA standard strain ATCC43300 was purch...

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Abstract

The invention relates to a new application of xiaobupleurum granules. Application of Xiaochaihu granules or Xiaochaihu granules combined with antibiotics in the preparation of medicines for preventing and treating methicillin-resistant Staphylococcus aureus infection. The present invention finds that Xiaobupleurum granules have anti-MRSA effect, and can be used in combination with erythromycin, ceftriaxone sodium, levofloxacin, and vancomycin to inhibit MRSA, and can be used as a natural antibacterial agent and antibiotic sensitizer for clinical application to MRSA Infection treatment.

Description

technical field [0001] The invention belongs to the field of Chinese patent medicines, and relates to a new application of a traditional Chinese medicine composition-Xiabupleurum granules combined with antibiotics. Background technique [0002] In recent years, with the widespread application of antibiotics, many bacterial infectious diseases have been effectively controlled. However, due to the high usage rate, long course of treatment, frequent replacement, blind selection, multiple combinations and other irrational use and abuse of antibiotics, the multidrug-resistant and pan-drug-resistant strains continue to increase. The choice of antibiotics is increasingly limited. Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common causes of multidrug-resistant infections, with significant morbidity and mortality, and has become a major cause of nosocomial and community-acquired infections one of the important pathogenic bacteria. As MRSA gradually develo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61K31/7048A61K31/546A61K31/5383A61K38/14A61K9/16A61P31/04
CPCA61K36/233A61K36/539A61K36/8888A61K36/344A61K36/9068A61K36/484A61K36/725A61K31/7048A61K31/546A61K31/5383A61K38/14A61K9/16A61P31/04A61K2300/00
Inventor 马蓉刘宏蒋研风羊郑如文江志强毕聪张俊华何逸禧杜海泳
Owner GUANGZHOU BAIYUSN GUANGHUA PHARMA
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