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Implant material capable of being used for human body soft tissue filling

A technology for implanting materials and soft tissues, which is applied in the field of medical materials to achieve the effect of maintaining the filling effect, the raw materials are easily available, and the raw materials are simple

Active Publication Date: 2021-09-21
ZHEJIANG SUJIA MEDICAL DEVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] This invention application has good biocompatibility and is suitable for soft tissue filling in cosmetic plastic surgery, such as the advantages of facial wrinkle removal and sunken filling, but it has not yet solved the above-mentioned question

Method used

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  • Implant material capable of being used for human body soft tissue filling
  • Implant material capable of being used for human body soft tissue filling
  • Implant material capable of being used for human body soft tissue filling

Examples

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Effect test

Embodiment 1

[0022] This embodiment provides an implant material that can be used for human soft tissue filling, including 50 parts by mass of cross-linked sodium hyaluronate gel, 14 parts of silicon dioxide, 8 parts of sodium oxide, 5 parts by mass 1 part of calcium oxide, 1 part of phosphorus pentoxide, 0.3 part of lidocaine hydrochloride and 0.75 part of dexamethasone.

[0023] Among them, the cross-linked sodium hyaluronate gel is prepared by the following method: according to the ratio of sodium hyaluronate powder and saline solution of 1:18, it is dissolved into a sodium hyaluronate solution, and sodium hydroxide is added to adjust the pH value of the solution to 9. , then add the cross-linking agent 1,4 butanediol diglycidyl ether, the amount of the cross-linking agent added is 3% of the mass of the sodium hyaluronate solution, slowly stir and heat to 70°C, cool to room temperature after continuing for 8 hours, At this time, the sodium hyaluronate solution has been cross-linked into...

Embodiment 2

[0026] This embodiment provides an implant material that can be used for human soft tissue filling, including 20 parts by mass of cross-linked sodium hyaluronate gel, 24 parts of silicon dioxide, 13 parts of sodium oxide, 18 parts by mass. 3 parts of calcium oxide, 4 parts of phosphorus pentoxide, 3 parts of lidocaine hydrochloride and 3 parts of dexamethasone.

[0027] Among them, the cross-linked sodium hyaluronate gel is prepared by the following method: dissolving sodium hyaluronate solution according to the ratio of sodium hyaluronate powder and normal saline 1:20, adding potassium hydroxide to adjust the pH value of the solution to 10 , then add the cross-linking agent divinyl sulfone, the amount of the cross-linking agent added is 5% of the mass of the sodium hyaluronate solution, slowly stir and heat to 80 ° C, cool to room temperature after continuing for 12 hours, at this time the sodium hyaluronate solution It has been cross-linked into a gel state, then add phospha...

Embodiment 3

[0030] This embodiment provides an implant material that can be used for human soft tissue filling, including 35 parts by mass of cross-linked sodium hyaluronate gel, 19 parts of silicon dioxide, 10 parts of sodium oxide, 12 parts by mass Parts of calcium oxide, 2.5 parts of phosphorus pentoxide, 1.5 parts of lidocaine hydrochloride and 2 parts of dexamethasone.

[0031] The preparation method of cross-linked sodium hyaluronate gel and biologically active inorganic silicate is the same as that in Example 1, so it will not be repeated here.

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Abstract

The invention relates to the technical field of medical materials, in particular to an implant material capable of being used for human body soft tissue filling. In order to solve the problems that in the prior art, the degradation speed is high, displacement is likely to occur, the filling effect cannot be well kept, and repeated injection filling is needed, the implant material capable of being used for human body soft tissue filling is provided and comprises sodium hyaluronate, bioactive inorganic silicate, lidocaine hydrochloride and dexamethasone. Cross-linked sodium hyaluronate gel is used as an implantation carrier, bioactive inorganic silicate particle components are compounded, and medicines such as lidocaine hydrochloride and dexamethasone are matched and injected into collapsed soft tissues needing to be filled, so that the collapsed soft tissues of a patient are recovered; through the physical properties of the cross-linked sodium hyaluronate and the bioactive inorganic silicate particles and the excellent biocompatibility, the degradation time can be greatly prolonged and is 5-8 times of the degradation time of the sodium hyaluronate gel in the prior art, and the filling effect can be kept for a long time.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to an implant material that can be used for human soft tissue filling. Background technique [0002] Although the materials currently used in the field of soft tissue filling, such as animal collagen, recombinant collagen, sodium hyaluronate gel, etc., have good effects, they still have a fast degradation rate, are prone to displacement, cannot maintain the filling effect well, and need to be repeated many times. The problem of injection filling not only increases the cost of medical operations for patients, but also wastes a lot of time costs for medical staff and patients. [0003] For example, a Chinese invention patent application discloses a soft tissue filling material and its preparation method [application number: 201510308687.X], which includes 36-51 parts of polyvinyl alcohol, 12-28 parts of polyacrylamide, 13 parts of hyaluronic acid -23 parts, 3-11 parts of so...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/02A61L27/20A61L27/54A61L27/50
CPCA61L27/025A61L27/20A61L27/54A61L27/50A61L2430/34A61L2300/102A61L2300/412A61L2300/43A61L2300/402C08L5/08
Inventor 鲍忆张建忠吉恒权张沈毅
Owner ZHEJIANG SUJIA MEDICAL DEVICE
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