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Preparation process of anesthetic drug composition

A preparation process and composition technology, applied in the field of preparation technology of anesthetic drug compositions, can solve the problems of poor patient tolerance, single component, patient injury, etc., and achieve the effects of good anesthesia effect and good drug effect.

Pending Publication Date: 2021-03-16
哈尔滨医大药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, the anesthetic drugs currently on the market have a single component, and when the anesthetic drugs play a role, the drug efficacy is poor, or the patient's tolerance is poor, so that the patient is injured due to insufficient anesthesia or other adverse reactions. Therefore, Propose a kind of preparation technology of anesthetic composition for the problems referred to above

Method used

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  • Preparation process of anesthetic drug composition
  • Preparation process of anesthetic drug composition
  • Preparation process of anesthetic drug composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A preparation process of an anesthetic composition, the preparation process comprising the following steps;

[0028] S1: Lidocaine hydrochloride, menthol, glycerin, ethanol and polysorbate are weighed according to the prescription amount, and the ratio of lidocaine hydrochloride: menthol: glycerin: ethanol: polysorbate is 30 parts: 5 parts: 200 Parts: 1000 parts: 15 parts;

[0029] S2: first put ethanol and clear water into the mixing equipment to make a 5% ethanol solution, then add lidocaine hydrochloride and menthol to the mixing equipment, stir until dissolved, add glycerin and polysorbate after dissolving, Stir for 45 minutes;

[0030] S3: adjusting the pH value of the solution in the mixing device to 3, filtering the medicinal solution, and performing water replenishment and sterilizing filtration on the medicinal solution, and then potting the medicinal solution.

[0031] Select 2 adult mice with the same health status, inject one of the mice with the existing ...

Embodiment 2

[0033] A preparation process of an anesthetic composition, the preparation process comprising the following steps;

[0034] S1: Lidocaine hydrochloride, menthol, glycerin, ethanol and polysorbate are weighed according to the prescription amount, and the ratio of lidocaine hydrochloride: menthol: glycerol: ethanol: polysorbate is 100 parts: 25 parts: 1200 Parts: 4500 parts: 200 parts;

[0035]S2: first put ethanol and clear water into the mixing equipment to make an ethanol solution with a concentration of 90%, then add lidocaine hydrochloride and menthol to the mixing equipment, stir until dissolved, add glycerin and polysorbate after dissolving, Stir for 45 minutes;

[0036] S3: adjusting the pH value of the solution in the mixing equipment to 8.0, and then filtering the medicinal solution, and performing hydration and sterilizing filtration on the medicinal solution, and then potting the medicinal solution.

[0037] Select 2 adult mice with the same health status, inject o...

Embodiment 3

[0039] A preparation process of an anesthetic composition, the preparation process comprising the following steps;

[0040] S1: Lidocaine hydrochloride, menthol, glycerin, ethanol and polysorbate are weighed according to the prescription amount, and the ratio of lidocaine hydrochloride: menthol: glycerin: ethanol: polysorbate is 60 parts: 15 parts: 700 Parts: 2200 parts: 115 parts;

[0041] S2: first put ethanol and clear water into the mixing equipment to make a 50% concentration of ethanol solution, then add lidocaine hydrochloride and menthol to the mixing equipment, stir until dissolved, add glycerin and polysorbate after dissolving, Stir for 45 minutes;

[0042] S3: adjusting the pH value of the solution in the mixing device to 5, then filtering the medicinal solution, and performing hydration and sterilizing filtration on the medicinal solution, and then potting the medicinal solution.

[0043] Select 2 adult mice with the same health status, inject one of the mice wit...

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Abstract

The invention relates to the technical field of anesthetic drugs, and particularly relates to a preparation process of an anesthetic drug composition. The preparation process comprises the following steps: S1, weighing lidocaine hydrochloride, menthol, glycerol, ethanol and polysorbate according to the prescription amount; wherein the ratio of the lidocaine hydrochloride to the menthol to the glycerol to the ethanol to the polysorbate is (30-100 parts): (1-25 parts): (200-1, 200 parts): (1, 000-4, 500 parts): (15-200 parts); S2, putting the ethanol and clear water into mixing equipment to prepare an ethanol solution with the concentration of 5%-90%, adding the lidocaine hydrochloride and the menthol into the mixing equipment, stirring the materials until dissolved, adding the glycerol andthe polysorbate after dissolving, and carrying out stirring for 10-60 minutes; and S3, adjusting the pH value of the solution in the mixing equipment to 2.0-8.0, then filtering the liquid medicine, carrying out water adding and aseptic filtration on the liquid medicine, and then carrying out encapsulation on the liquid medicine. The prepared anesthetic drug is better in drug effect, the problem that the traditional anesthetic drugs are poor in anesthetic effect is solved, and a patient is prevented from being injured due to insufficient anesthesia.

Description

technical field [0001] The invention relates to the technical field of drugs, in particular to a preparation process of an anesthetic drug composition. Background technique [0002] Narcotic drugs refer to drugs that have an anesthetic effect on the central nervous system, are used continuously, abused or used irrationally, and are prone to physical and mental dependence, and can lead to addiction. However, when performing medical work, it is necessary to inject anesthesia drugs to the patient so as to facilitate the work of medical personnel. [0003] In the prior art, the anesthetic drugs currently on the market have a single component, and when the anesthetic drugs play a role, the drug efficacy is poor, or the patient's tolerance is poor, so that the patient is injured due to insufficient anesthesia or other adverse reactions. Therefore, In view of the above problems, a preparation process of an anesthetic drug composition is proposed. Contents of the invention [00...

Claims

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Application Information

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IPC IPC(8): A61K31/167A61K47/10A61K47/26A61P23/00B01F15/00B01F7/20B01F27/906
CPCA61K31/167A61K47/10A61K47/26A61P23/00B01F27/906B01F35/121B01F35/123B01F35/4111B01F2101/22
Inventor 徐俭尤旭王立艳赵春莹谢骥李佳琳
Owner 哈尔滨医大药业股份有限公司
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